A5006895736- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Infant Nutrition and Health
- Liver Disease Diagnosis and Treatment
- Polysaccharides Composition and Applications
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and disorders
- Clostridium difficile and Clostridium perfringens research
- Coronary Interventions and Diagnostics
- Muscle metabolism and nutrition
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Pediatric Urology and Nephrology Studies
- Sphingolipid Metabolism and Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Chromatography in Natural Products
- Alcohol Consumption and Health Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
Aristotle University of Thessaloniki
2016-2025
Athens Naval & Veterans Hospital
2024
Centre for Research and Technology Hellas
2022
Detailed investigation of the lipidome remodeling upon normal weight conditions, obesity, or loss, as well influence physical activity, can help to understand mechanisms underlying dyslipidemia in metabolic conditions correlated emergence and progression non-alcoholic fatty liver disease (NAFLD). C57BL/6 male mice were fed a diet (ND) high-fat (HFD) for 20 weeks. Subgroups within group underwent different interventions: some engaged exercise (HFDex), others subjected loss (WL) by changing...
Abstract Background Diabetes mellitus (DM) and coronary artery disease (CAD) constitute inter-related clinical entities. Biomarker profiling emerges as a promising tool for the early diagnosis risk stratification of either DM or CAD. However, studies assessing predictive capacity novel metabolomics biomarkers in coexistent CAD are scarce. Methods This post-hoc analysis CorLipid trial (NCT04580173) included 316 patients with comorbid who underwent emergency elective angiography due to acute...
Recent studies support that acylcarnitines exert a significant role in cardiovascular disease development and progression. The aim of this metabolomics-based study was to investigate the association serum acylcarnitine levels with coronary artery (CAD) severity, as assessed via SYNTAX Score. Within context prospective CorLipid trial (NCT04580173), 13 circulating were accurately determined through newly developed HILIC-MS/MS method 958 patients undergoing angiography AHEPA University Hospital...
Exercise is important in the prevention and treatment of metabolic syndrome (MetS), a cluster risk factors that raises morbidity. Metabolomics can facilitate optimization exercise prescription. This study aimed to investigate whether response human urinary fingerprint depends on presence MetS or mode. Twenty-three sedentary men (MetS, n = 9, Healthy, 14) completed four trials: resting, high-intensity interval (HIIE), continuous moderate-intensity (CME), resistance (RE). Urine samples were...
Aging is an inevitable condition leading to health deterioration and death. Regular physical exercise can moderate the metabolic phenotype changes of aging. However, only a small number metabolomics-based studies provide data on effect along with Here, urine whole blood samples from Wistar rats were analyzed in longitudinal study explore alterations due The comprised three different programs exercises, including life-long protocol which started at age 5 months ended 21 months. An acute...
Abstract Background Coronary artery disease (CAD) remains one of the leading causes mortality and morbidity worldwide. As oxygen nutrient supply to myocardium significantly decrease during ischemic periods, important changes occur regarding myocardial intermediary energy metabolism. Metabolomics is an emerging field in systems biology, which quantifies metabolic response progression. This study aims evaluate diagnostic utility plasma metabolomics-based biomarkers for determining complexity...
Exercise plays a beneficial role in the treatment of metabolic syndrome (MetS). Metabolomics can provide new insights and facilitate optimization exercise prescription. This study aimed to investigate whether response human serum fingerprint depends on mode or presence MetS. Twenty-three sedentary men (nine with MetS fourteen healthy) completed four trials: Resting, high-intensity interval (HIIE), continuous moderate-intensity (CME), resistance (RE). Blood samples were collected...
The GRACE score constitutes a useful tool for risk stratification in patients with acute coronary syndrome (ACS), while the SYNTAX determines complexity of artery disease (CAD). This study sought to correlate these scores and assess accuracy predicting extent CAD. A total 539 ACS undergoing angiography were included this analysis. classified into those < 33 ≥ 33. Spearman's correlation receiver operator characteristic analysis conducted investigate role as predictor score. There was...
Physical exercise can reduce adverse conditions during aging, while both and aging act as metabolism modifiers. The present study investigates rat fecal cecal metabolome alterations derived from rats' lifespan.Groups of rats trained life-long or for a specific period time were under study. training protocol consisted swimming, 15-18 min per day, 3-5 days week, with load 4-0% rat's weight. Fecal samples extracts analyzed by targeted untargeted metabolic profiling methods (GC-MS LC-MS/MS)....
Alcoholic liver disease (ALD) as a consequence of ethanol chronic consumption could lead to hepatic cirrhosis that is linked high morbidity and mortality. Disease diagnosis still very challenging usually clear findings are obtained in the later stage ALD. The profound effect on metabolism can be depicted using metabolomics; thus, discovery novel biomarkers shed light initiation progression ALD, serving diagnostic purposes. In present study, Hydrophilic Interaction Liquid Chromatography...
Developing risk assessment tools for CAD prediction remains challenging nowadays. We developed an ML predictive algorithm based on metabolic and clinical data determining the severity of CAD, as assessed via SYNTAX score. Analytical methods were to determine serum blood levels specific ceramides, acyl-carnitines, fatty acids, proteins such galectin-3, adiponectin, APOB/APOA1 ratio. Patients grouped into: obstructive (SS > 0) non-obstructive = 0). A (boosted ensemble XGBoost) was by combining...
Late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) are major causes of neonatal morbidity mortality. In this prospective, case-control study, we evaluated the metabolic profile neonates with LOS NEC. Blood samples were collected from 15 septic 17 NEC at clinical suspicion specific diseases. Sixteen gestational postnatal age-matched without sepsis/NEC served as controls. Serum profiles assessed using liquid chromatography–quadrupole time-of-flight mass spectrometry. Metabolomic...
ST-elevation myocardial infarction (STEMI) remains one of the leading causes mortality worldwide. The identification novel metabolic and imaging biomarkers could unveil key pathophysiological mechanisms at molecular level promote personalized care in patients with acute coronary syndromes. We studied 38 STEMI who underwent primary percutaneous intervention thrombus aspiration. sought to correlate serum ceramide levels micro-CT quantified aspirated volume relevant angiographic outcomes,...
Carob (Ceratonia siliqua) is an exceptional source of significant bioactive compounds with great economic importance in the Mediterranean region, where it widely cultivated. fruit used for production a variety products and commodities such as powder, syrup, coffee, flour, cakes, beverages. There growing evidence beneficial effects carob made from on range health problems. Therefore, metabolomics could be to explore nutrient-rich carob. Sample preparation crucial step metabolomics-based...
The chronic and acute effect of ethanol administration on the metabolic phenotype mouse brain was studied in a C57BL/6 model abuse using both untargeted targeted ultra performance liquid chromatography-tandem mass spectrometry. Two experiments based either (8 week) exposure to male female mice or for 11 days, plus 2 oral gavage doses 25% ethanol, were undertaken. Marked differences found amino acids, nucleotides, nucleosides, related metabolites as well number different lipids. Using...