A5066359097- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- SARS-CoV-2 detection and testing
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Mosquito-borne diseases and control
- Carbon and Quantum Dots Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Galectins and Cancer Biology
- Insect symbiosis and bacterial influences
- Natural product bioactivities and synthesis
- Dendrimers and Hyperbranched Polymers
- Viral Infections and Vectors
- Cancer Mechanisms and Therapy
- Plant Gene Expression Analysis
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- Magnolia and Illicium research
- Immune cells in cancer
- Photosynthetic Processes and Mechanisms
- interferon and immune responses
Stanford University
2024
Stratford University
2024
Xiamen University
2021-2024
South China Normal University
2016-2018
Sun Yat-sen University
2018
Fifth Affiliated Hospital of Sun Yat-sen University
2018
Second Military Medical University
2013
Chinese Academy of Forestry
2011
Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed remodeling The Fe-TCPP-MOFs were utilized not only as core catalysis component against destruction but also biocompatible delivery vector of an immunologic agonist, improving long circulation and enrichment. Concurrently, it...
Abstract CRISPR (clustered regularly interspaced short palindromic repeats) technology holds tremendous promise for gene regulation and editing. However, precise control of editing is essential to overcome its uncontrollable reaction process excessive activity that leads off-target To this problem, we engineered a photoswitch on G-quadruplex gRNA (GqRNA) precisely controlled expression by embedding dicationic azobenzene derivatives (AZD++). Our results demonstrated rational design the onto...
Photothermal therapy has shown great promise for cancer treatment and second near-infrared (NIR-II) -absorbing particles could further improve its precision applicability due to superior penetration depth new imaging ability. Herein, high NIR-II-absorbing polymer were prepared by using soluble isobutyl-substituted diammonium borates (P-IDI). The P-IDI showed stronger absorption at 1000-1100 nm, which exhibited excellent photostability, strong photoacoustic ability photothermal conversion...
Antibiotic resistance, the ability of some bacteria to resist antibiotic drugs, has been a major global health burden due extensive use agents. resistance is encoded via particular genes; hence specific detection these genes necessary for diagnosis and treatment resistant cases. Conventional methods monitoring require sample be transported central laboratory tedious sophisticated tests, which grueling time-consuming. We developed paper-based chip, integrated with loop-mediated isothermal...
The catalytic activities of currently developed peroxidase-mimic nanozymes are generally limited. Therefore, further efforts still needed to improve the performance peroxidase nanozymes. Herein, we synthesized Fe-coordinated carbon nanozyme dots (Fe-CDs) that can serve as both efficient and T2-magnetic resonance imaging (MRI) contrast agents. intrinsic peroxidase-like activity Fe-CDs was explored by oxidation 3,3′,5,5′-tetramethylbenzidine (TMB) with hydrogen peroxide (H2O2). product showed...
Small RNAs have been considered as potential biomarkers of various human diseases. Sensitive and multiplexed determination small with point-of-care (POC) assay would be great significance. Herein, an integrated paperfluidic chip device for RNA analysis was developed the first time. In this system, extraction purification completed through a poly(ether sulfone) (PES) paper without need centrifugation. Subsequently, newly designed hairpin probe-exponential amplification reaction (HP-EXPAR)...
Zika virus (ZIKV) is a mosquito-borne flavivirus that leads to devastating consequences for fetal development. However, accurate diagnosis of ZIKV made difficult by the fact most infected patients are asymptomatic or present with symptoms similar those other febrile illnesses. Thus, development simple, accurate, highly sensitive, and reliable method biomedical analysis needed. Herein, novel liquid biopsy system was constructed via dendritic Ru(bpy)32+-polymer-amplified...
Abstract Galectin-1 is overexpressed in a wide range of malignant cancers and strongly associated with immune suppression as well cancer aggressiveness. However, effective therapeutics targeting remain elusive clinical practice. Herein, we report an activatable nano-system, termed Pr5S, to downregulate through vivo gene silencing. Pr5S features bio-responsive lattice that can protect siRNA during circulation efficiently break down for interference upon exposure the elevated reductive...