A5024964125- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- HIV-related health complications and treatments
- Epigenetics and DNA Methylation
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Pharmacology and Obesity Treatment
- Regulation of Appetite and Obesity
- Atherosclerosis and Cardiovascular Diseases
- Natural Antidiabetic Agents Studies
- Systemic Lupus Erythematosus Research
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Genetic Syndromes and Imprinting
- Gestational Diabetes Research and Management
- Immune cells in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Platelet Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer-related molecular mechanisms research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of KwaZulu-Natal
2017-2020
Cape Peninsula University of Technology
2017
Abstract Platelet activation has been described in patients with chronic inflammation, however type 2 diabetes mellitus it remains controversial. We compared levels of platelet leucocyte aggregates, monocyte and granulocyte across glucose tolerance statuses mixed ancestry South Africans. Individuals (206) were recruited from Bellville-South, Cape Town, included 66% normal tolerance, 18.7% pre-diabetes, 8.7% screen-detected 6.3% known diabetes. Monocyte neutrophil measured by calculating the...
High-fat diet (HFD) feeding is known to induce metabolic dysregulation, however, less on its impact in promoting the hypercoagulable state. This current study aimed evaluate platelet-monocyte aggregate (PMA) formation following short-term HFD feeding. particularly important for understanding link between inflammation and state during early onset of dysregulation. To explore such a hypothesis, mice were fed 8 weeks, with body weights as well insulin blood glucose levels monitored weekly basis...
To assess the levels of glycoprotein GPIV (CD36) expression on peripheral blood monocyte subsets, in a mouse model glucose intolerance. Moreover, to determine effect of; low-dose aspirin (LDA) alone, LDA combined with metformin, or clopidogrel CD36 subsets circulating monocytes.The study consisted two experimental phases. In experiment one, mice (n = 14) were randomised receive low-fat diet (LFD) high-fat (HFD) for eight weeks. Whereas secondary phase experiment, comprised twenty-four...
Abstract Objective To assess peripheral lymphocyte DNA methylation profiles in prediabetes using a high fat-diet-fed C57BL/6 animal model. We further evaluated whether low dose-aspirin, or low-dose aspirin combination with metformin, could modulate global levels blood lymphocytes. Methods Twenty-eight (28) male mice were used two experimental phases. The first experiment involved animals (n=16) which randomised to receive low-fat diet (LFD) high-fat (HFD) (n = 8/group) for 10 weeks. Whereas...