A5043108545- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Immunotherapy and Immune Responses
- Whipple's Disease and Interleukins
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Complement system in diseases
- Pituitary Gland Disorders and Treatments
- Blood groups and transfusion
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Antifungal resistance and susceptibility
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- Biochemical and Molecular Research
- Adrenal Hormones and Disorders
- CNS Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Pancreatitis Pathology and Treatment
Nagoya University
2022-2025
Japanese Red Cross Nagoya Daiichi Hospital
2021
Kagoshima City Hospital
2014
The prognosis of adrenoleukodystrophy (ALD)with neurological involvement is generally dismal; however, allogeneic stem cell transplantation (SCT) recognized as effective to stabilize or improve the clinical symptoms ALD. Herein, we report outcomes patients with ALD who consecutively underwent reduced intensity conditioning at our institution.Sixteen ALD, were symptomatic (n = 14) presymptomatic 2), received SCT from 2010 2016. source was cord blood 14), bone marrow a human leukocyte antigen...
Allogeneic hematopoietic cell transplantation (HCT) is a crucial treatment for various diseases, including hematological malignancies, solid tumors, and genetic disorders. Despite its curative potential, HCT associated with severe complications, notably infections, graft-versus-host disease, organ damage. Infections, particularly bloodstream infections (BSIs), pose significant threat in the initial weeks post-HCT, necessitating effective management strategies. This retrospective study aimed...
Non-tuberculous mycobacterial infection (NTM) is rare in healthy children, with lymphadenitis being the most common presentation. Immunocompromised populations are known to be at high risk, but clinical picture of NTM pediatric hematology/oncology patients unclear. In this nationwide retrospective analysis under age 40 treated Japanese departments who developed between January 2010 and December 2020, 36 (21 hematopoietic stem cell transplantation (HSCT) 15 nontransplant patients) were...
Introduction Sinusoidal obstruction syndrome (hSOS) and thrombotic microangiopathy (TMA) are life-threatening complications caused by endothelial cell damage (ECD) associated with hematopoietic transplantation (HCT). Danaparoid sodium (DS) is a heparinoid comprising mixture of low molecular weight glycosaminoglycans anti-Xa anti-IIa effects, which prevent fibrin formation. Recombinant thrombomodulin (rTM) comprises the active extracellular domain inactivates coagulation binding to thrombin....
We report the case of a 75-year-old female patient with history Hashimoto's thyroiditis who presented congestive heart failure caused by atrial fibrillation associated isolated adrenocorticotropic hormone (ACTH) deficiency. This is first combination these complex conditions. Clinical conditions in ACTH deficiency and can be variable. Thus, it sometimes difficult to establish diagnosis. The mechanism underlying may some cases. Various affect patients simultaneously. Therefore, making proper...
An 18-year-old male patient who had been diagnosed with chronic granulomatous disease at 2 years old and suffering from repeated severe infections underwent human leukocyte antigen haploidentical bone marrow transplantation his mother using reduced intensity conditioning. After engraftment, donor lymphocyte infusion was initiated to decrease chimerism on day 96. On 120, acute graft-versus-host occurred; hence, steroid administration initiated. 173, a generalized convulsion multiple abscesses...
Melphalan is widely used for hematopoietic stem cell transplantation (HSCT) conditioning. However, the relationship between its pharmacokinetic (PK) and outcomes in children has not been thoroughly investigated. We prospectively analyzed melphalan area under curve (AUC) outcome examined development of a predictive model clearance children. This study included 43 aged 0 to 19 years who underwent HSCT following melphalan-based conditioning regimen from 2017 2021. In univariable analysis,...