A5011015974- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Diabetes Management and Research
- Cardiovascular Disease and Adiposity
- Chronic Disease Management Strategies
- Heart Failure Treatment and Management
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Physical Activity and Health
- Non-Invasive Vital Sign Monitoring
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Kidney Disease and Diabetes
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Diabetes and associated disorders
- Frailty in Older Adults
- Diabetes Management and Education
- Dialysis and Renal Disease Management
- Neurological Disorders and Treatments
Baker Heart and Diabetes Institute
2014-2024
Monash University
2023-2024
The University of Melbourne
2018-2024
The Royal Melbourne Hospital
2018-2020
The University of Queensland
2007-2015
Julian Hospital
2015
Cleveland Clinic
2011-2012
Indiana University School of Medicine
2011-2012
Princess Alexandra Hospital
2007-2012
Greenslopes Private Hospital
2011
OBJECTIVE To determine whether interrupting prolonged sitting with brief bouts of light-intensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In a randomized crossover trial, 24 inactive overweight/obese T2D (14 men 62 ± 6 years old) underwent the following 8-h conditions on three separate days (with 6–14 washout): uninterrupted (control) (SIT), plus 3-min LW (3.2 km · h−1)...
Prolonged sitting is increasingly recognized as a ubiquitous cardiometabolic risk factor, possibly distinct from lack of physical exercise. We examined whether interrupting prolonged with brief bouts light-intensity activity reduced blood pressure (BP) and plasma noradrenaline in type 2 diabetes (T2D).In randomized crossover trial, 24 inactive overweight/obese adults T2D (14 men; mean ± SD; 62 6 years) consumed standardized meals during 3 × 8 h conditions: uninterrupted (SIT); + half-hourly...
Metabolic and vascular disturbances contribute to diabetic cardiomyopathy, but the role of interstitial fibrosis in early disease is unproven. We sought assess relationship between imaging markers diffuse myocardial dysfunction link this possible causes cardiomyopathy.Hemodynamic metabolic data were measured 67 subjects with type 2 diabetes mellitus (age 60±10 years) no cardiac symptoms. Myocardial function was evaluated standard echocardiography deformation; ischemia excluded by exercise...
To examine psychosocial and behavioural impacts of the novel coronavirus disease 2019 (COVID-19) pandemic lockdown restrictions among adults with type 2 diabetes.Participants enrolled in PRogrEssion DIabetic ComplicaTions (PREDICT) cohort study Melbourne, Australia (n = 489 a baseline assessment pre-2020) were invited to complete phone/online follow-up mid-2020 (i.e., amidst COVID-19 restrictions). Repeated assessments that compared pre-COVID-19 levels included anxiety symptoms (7-item...
Central blood pressure (BP) and markers of wave reflection (augmentation index; AIx) measured by radial tonometry have prognostic value independent from brachial BP. The measurement the central waveform is increasingly used during altered hemodynamics, including exercise, but reliability test has not been reported under changed loading conditions. This study aimed to technique's reproducibility major hemodynamic perturbations induced exercise.Radial waveforms were recorded (SphygmoCor) in 28...
Significance Statement Modifiable risk factors, such as low physical activity, contribute to cardiovascular mortality in patients with CKD. In a randomized trial of 160 CKD, nurse-led, multidisciplinary lifestyle intervention that included exercise training significantly increased cardiorespiratory fitness (peak O 2 uptake) CKD at 12 months compared usual care; peak uptake declined near baseline levels thereafter but remained elevated care after 3 years follow-up. The also markedly capacity...
Poor prognosis associated with blunted post-exercise heart-rate recovery may reflect autonomic dysfunction. This study sought the accuracy of in diagnosis cardiac neuropathy, which represents a serious, but often unrecognized complication Type 2 diabetes.Clinical assessment neuropathy and maximal treadmill exercise testing for were performed 135 patients diabetes negative echocardiograms. Cardiac was defined by abnormalities ≥ 7 function markers, including four reflex tests three indices...
Heart rate variability may be used to assess diabetic cardiac autonomic neuropathy. The aim of the present study was determine reliability standard short-term clinical measurements heart in patients with Type 2 diabetes.In 24 diabetes (11 male, age 61 ± 9 years), parameters time domain (standard deviation RR intervals, coefficient variation intervals and root mean square successive interval differences) frequency (very low frequency, high total spectral power) were derived from a 5-min...
Background: The role of chronic kidney disease (CKD) as a risk factor for cognitive impairment independent their shared antecedents remains controversial. Objective: To determine whether damage (indicated by albuminuria) or dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m 2 ) predict future (12-year) function independently factors. Methods: We studied 4,128 individuals from the 1999/00 population-based Australian Diabetes, Obesity, and Lifestyle (AusDiab) Study...
BackgroundSubclinical diabetic cardiomyopathy (DCM) is frequent in asymptomatic subjects with type 2 diabetes (T2DM). We sought the response of functional and fibrosis markers to therapy a trial aldosterone antagonism for treatment DCM.
To examine mild cognitive impairment and its associations with subclinical cardiac dysfunction in patients chronic heart disease yet to develop the clinical syndrome of failure (CHF). Patients from Nurse-led Intervention for Less Chronic Heart Failure Study (n = 373 other than CHF; 64 ± 11 years, 69% men) were screened [Montreal assessment (MoCA) score <26] underwent echocardiographic/clinical profiling. We investigated MoCA domain subscores global status ('normal' vs. 'diastolic...
Abstract Background Excess mortality in people with vs without type 2 diabetes (T2DM) has fallen, but it is unclear whether men/women at all ages have benefited and which causes of death driven these trends. Methods All-cause cause-specific rates excess [by rate ratios (MRRs) relative to the non-diabetic general population] were examined 1 268 018 Australians T2DM registered on National Diabetes Services Scheme (2002–2014). Results Age-standardized decreased men (−2.2%/year; Ptrend &lt;...
Background Hypertension is ubiquitous in patients with heart failure and preserved ejection fraction (HFpEF) contributes to arterial ventricular stiffening. Exertional dyspnea may result from diastolic dysfunction exercise; however, the association of central blood pressure (BP) left filling during exercise has not been assessed this population was aim study. Methods Fifteen HFpEF 15 age-matched sex-matched controls were studied at rest, submaximal immediately after maximal exercise....
Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation index (AIx) a measure of systemic arterial stiffness and independently predicts outcome.The objective this study was to assess the effect standardized high-fat meal on metabolic parameters AIx in 1) lean, 2) obese nondiabetic, 3) subjects with type 2 diabetes mellitus (T2DM).Male (lean, n = 8; obese, 10; T2DM, 10) were studied for 6 h after water control. Glucose, insulin, triglycerides, (radial...
QT Variability and Sympathetic Dysinnervation. The mechanism of adverse prognosis attributable to proarrhythmic cardiac sympathetic dysinnervation in patients with type 2 diabetes is incompletely understood. This study sought the association temporal instability ventricular repolarization assessed by beat-to-beat interval variability. (123) I-metaiodobenzylguanidine ((123) I-MIBG) scintigraphy was analyzed 31 diabetic for (4-hour heart-to-mediastinum ratio <1.8) regional integrity washout...