A5008126051- Molecular Sensors and Ion Detection
- Phytochemistry and Bioactive Compounds
- Luminescence and Fluorescent Materials
- Catalytic Alkyne Reactions
- Marine Sponges and Natural Products
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Traditional Chinese Medicine Analysis
- Healthcare and Venom Research
- Sulfur Compounds in Biology
- Cancer, Hypoxia, and Metabolism
- Phytochemical compounds biological activities
- Medicinal plant effects and applications
- Synthesis and Reactivity of Heterocycles
- Traditional Chinese Medicine Studies
- RNA and protein synthesis mechanisms
- Ginkgo biloba and Cashew Applications
- Biochemical and Molecular Research
- Catalytic Cross-Coupling Reactions
- Influenza Virus Research Studies
- Phytochemical Studies and Bioactivities
- Cancer Treatment and Pharmacology
- Phytochemicals and Antioxidant Activities
- Advanced biosensing and bioanalysis techniques
Macau University of Science and Technology
2017-2021
Quality Research
2017-2020
Yahoo (United Kingdom)
2019
Southwest Medical University
2019
Yuli Hospital
2017
Shanghai Institute of Organic Chemistry
2014
Chinese Academy of Sciences
2013-2014
Wake Forest University
2013
Hong Kong Baptist University
2011
East China Normal University
2007-2008
Abstract Gold‐catalyzed cascade cyclization/1,2‐rearrangement of 1‐(2‐furanyl)phenyl propargyl alcohols has been developed, which provides a rapid and efficient access to multisubstituted 1‐naphthols bearing an enal or enone moiety with high stereoselectivity. The ( Z )‐ E )‐stereochemistry can be easily controlled by choosing protected‐ non‐protected substrates. utility the methodology illustrated in first total synthesis wailupemycin G.
A convenient BF3·Et2O-catalyzed Friedel−Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1H-indene derivatives in good high yields under mild conditions. Further, the iodoindene are valuable synthetic building blocks for elaboration molecular complexity, such as construction multiaryl substituted indenes by Suzuki coupling reaction.
Gold-catalyzed cycloisomerization of 1,7-diyn-3,6-bis(propargyl carbonate)s leads to a highly efficient and diastereoselective synthesis functionalized naphtho[b]cyclobutenes. A cascade sequence involving gold-catalyzed double 3,3-rearrangement, 6π-electrocyclic reaction decarbonylative cyclization was proposed for this reaction.
Influenza virus (IV) infections usually cause acute lung injury characterized by exaggerated proinflammatory responses. The paucity of therapeutic strategies that target host immune response to attenuate poses a substantial challenge in management IV infections. In this study, we chemically synthesized novel fatty acid (2Z,4E)-deca-2,4-dienoic (DDEA) identified from Chinese Cordyceps using UHPLC–Q-TOF–MS techniques. DDEA did not inhibit H1N1 replication but attenuated responses reducing mRNA...
Two mesitylene based neutral receptors 1 and 2 bearing two thiourea binding sites were constructed as fluorescent probes for sensing dicarboxylates. Their affinities toward dicarboxylates, aspartate glutamate have been investigated in acetonitrile solution by fluorescence titration experiments. Both sensors exhibited some ability to discriminate the antipodal forms of glutamate.
Eleven dauricine derivatives were synthesized and evaluated for their anti-cancer effect in different cancer cells autophagic activity HeLa model cell. Among these newly compounds, carbamates 2a, 2b, carbonyl ester 3a sulfonyl 4a exhibited potent cytotoxic effects on tested with IC50 values ranged from 2.72 to 12.53 μM, which more than that of (higher 15.53 μM). The above four are validated induce autophagy-dependent cell death cells. These findings offer us a promising source generating...
Abstract Increased energy metabolism is responsible for supporting the abnormally upregulated proliferation and biosynthesis of cancer cells. The key cellular sensor AMP-activated protein kinase (AMPK) glycolytic enzyme alpha-enolase (α-enolase) have been identified as targets active components ginseng. Accordingly, ginseng or ginsenosides demonstrated with their potential values treatment and/or prevention via regulation balance. Notably, our previous study that R -form derivative 20(...
It was recently reported that an I223R/H275Y double mutant of neuraminidase (NA) creates a multidrug-resistant form the pandemic influenza A (H1N1) virus. However, comprehensive understanding molecular mechanisms is still lacking. We conducted systematic in silico study to explore structural basis underlying this multidrug resistance. By docking analyses and dynamics (MD) simulations, we compared various biochemical biophysical properties wild type, I223R single NA with two inhibitors,...
Seven novel 12-phenyl berberines (<bold>3a–3f</bold>,<bold>3k</bold>) showed more potent inhibitory effect on hypoxia-induced HIF-1 transcriptional activity than the parent berberine.
A ratiometric fluorescent probe based on a Cd(2+)-ACAQ complex was designed and demonstrated for the chemo- enantioselective detection of cysteine in 99:1 buffered HEPES:ACN solutions. Under measuring conditions, sensor demonstrates high selectivity toward Cys against Hcy GSH, an enantioselectivity 3.35 can be achieved antipodal forms Cys.
Ginkgolides are the most important components of Ginkgo biloba extracts, whose lactone can be hydrolyzed in aqueous environment. Although products have complex structures and their functions not well-understood, opening ring is an strategy producing novel derivatives ginkgolide. The preparation a single pure aminolyzed ginkgolide for study its bioactivity understanding process aminolysis challenging. To obtain stable products, four amide (2–5) B (GB, 1) were prepared via ring-opening...
Purpose: To investigate the protective effect of acetone extract Rumex japonicas Houtt. (AER) on rat myocardial cells.Methods: R. was extracted with 75 % aqueous ethanol by reflux to afford total (TER). TER suspended in water and then fraction (AER). High performance liquid chromatography (HPLC) combined standard substances carried out analyze major constituents AER. Apoptosis H9c2 cell line induced H2O2 (100 μmol/L). The cells were treated AER (50, 100 200 μg/mL, viability evaluated...
Abstract Five 21‐alkylidenes ( 2 ‐ 6 ) and a 21‐alkylol 7 derivatives of uscharin 1 were synthesized by aldol condensation reaction with aromatic aldehydes, respectively. We investigated the ability its to interfere intracellular calcium level flow cytometry contractile characteristics at single cell time‐lapse microscopy in H9c2 cells. Changes spontaneous oscillations beating HL‐1 cells also studied high‐throughput Fluorometric Imaging Plate Reader (FLIPR) assay. reported for first time...
Abstract Uscharin‐like non‐classical cardenolides are considered to be useful as HIF‐1 inhibitors in the treatment of cancers. To develop more potent inhibitors, oximes and oxime ethers uscharin were designed synthesized. Oximation exhibited unexpectedly a regioselectivity stereoselectivity at 3′‐thiazoline but not 19‐aldehyde group, since either E ‐ketoxime derivative 2 or its ether 5 C‐3′ was found only product during oximation using hydroxylamine methoxyamine room temperature. Two...
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