A5100382586- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Research and Treatments
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- bioluminescence and chemiluminescence research
- Proteoglycans and glycosaminoglycans research
- Renal and related cancers
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Ginseng Biological Effects and Applications
- Telomeres, Telomerase, and Senescence
- Genetic and Kidney Cyst Diseases
- Nuts composition and effects
- GABA and Rice Research
- Molecular Biology Techniques and Applications
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biological and pharmacological studies of plants
- Cancer, Lipids, and Metabolism
- ATP Synthase and ATPases Research
- Biochemical and Molecular Research
- Metabolomics and Mass Spectrometry Studies
Shandong Academy of Chinese Medicine
2025
Huzhou University
2024
Henan University
2021
Ningxia Medical University
2021
Henan Provincial People's Hospital
2020-2021
Zhengzhou University
2020-2021
Hunan Normal University
2021
Hunan Provincial People's Hospital
2021
Hunan Provincial Center for Disease Control and Prevention
2021
Tianjin Medical University Cancer Institute and Hospital
2020
Based on the pharmacokinetics theory, this study investigated pharmacokinetic characteristics of albiflorin, paeoniflorin, wogonoside, and wogonin in normal febrile rats summarized absorption elimination rules Dayuanyin them to provide reference for further development clinical application Dayuanyin. Blood samples were taken from fundus venous plexus model after intragastric administration at different time points. The concentration each substance blood was determined by ultra performance...
The present study aimed to explore the expression of microRNA (miRNA or miR) in drug‑resistant and drug‑sensitive ovarian cancer cell lines, seek potential therapeutic target mechanism order improve drug resistance by altering miRNA levels. characteristics SKOV3/DDP, SKOV3, COC1/DDP COC1 lines were studied. miRNAs that differentially expressed between cisplatin‑resistant cells its parental screened with a chip. effect was detected, their investigated transfection...
Background: Clinical tolerance to trastuzumab greatly affects the therapeutic effect in breast cancer (BC). Long-chain non-coding RNA (lncRNA) plays an important role development of resistance, which SNHG7 can promote epithelial mesenchymal transformation (EMT) cells into, while EMT is related resistance cells. Objective: To investigate whether lncRNA-SNHG7 enhance chemotherapy and cell viability BC by regulating miR-186. Methods: SK-BR-3 HER2+BC were induced miR-186, regulate expression...
Background: Breast cancer is the most common malignancy, and approximately 70% of breast cancers are estrogen receptor-α (ERα) positive. The anti-estrogen tamoxifen a highly effective commonly used treatment for patients with ER+ cancer. However, 30% fail adjuvant therapy metastatic develop resistance. Although increasing evidence suggests that microRNA (miRNA) dysregulation influences sensitivity, mechanism cross-talk between miRNA ERα signaling remains unclear. miR-575 has been reported to...
It has previously been demonstrated that microRNAs (miRNAs) have essential roles and participate in various biological processes by regulating their specific target genes. However, the precise role of miRNAs ovarian cancer (OC) not yet elucidated. The present study miR‑614 expression levels were significantly upregulated OC tissues cell lines, whereas decreased opposite effects. Furthermore, gain‑of‑function loss‑of‑function experiments indicated overexpression promoted proliferation...
Abstract Background Long noncoding RNAs (lncRNAs) have been elucidated to participate in the development and progression of various cancers. In this study, we aimed explore underlying functions mechanisms LINC00958 colorectal cancer. Methods expression cancer tissues was examined by qRT-PCR. The correlations between clinical characteristics prognosis were evaluated. biological detected CCK-8, MTT, colony formation flow cytometric analyses. RNA pulldown, RIP luciferase reporter assays used...
Abstract Objectives Although the Hox transcript antisense intergenic RNA (HOTAIR), a vital long non-coding RNA, is known to participate in development and progression of wide range carcinomas, there are still no published reports regarding its expression adenocarcinoma esophagogastric junction (AEJ). The aims this study were investigate HOTAIR, analyze association with PI3K/Akt pathway activation clinical AEJ patients. Methods Nine normal epithelial tissues 41 samples studied comparably....
Abstract Increased energy metabolism is responsible for supporting the abnormally upregulated proliferation and biosynthesis of cancer cells. The key cellular sensor AMP-activated protein kinase (AMPK) glycolytic enzyme alpha-enolase (α-enolase) have been identified as targets active components ginseng. Accordingly, ginseng or ginsenosides demonstrated with their potential values treatment and/or prevention via regulation balance. Notably, our previous study that R -form derivative 20(...
Doxorubicin (DOX) is currently one of the most widely used and effective drugs for treatment breast cancer, but drug resistance in cancer often leads to poor efficacy. MicroRNAs (miRNAs) are involved development progression various tumors increasing number studies have confirmed that abnormal miR-520b expression closely associated cancer. We analyzed clinical features, including miR-520b, 30 patients with Further, we interaction between insulin-like growth factor 1 receptor (IGF-1R) cell....
This study was designed to investigate the effect of long non-coding RNA (lncRNA) OIP5-AS1 on cell migration and invasion gallbladder cancer (GBC) its specific mechanism.The expressions lncRNA miR-143-3p in GBC lines (GBC-SD, SGC996 NOZ) epithelial cells (HGBE cells) were measured by qRT-PCR. After loss- gain-of-function experiments for GBC-SD cells, CCK-8 applied examine viability, scratch assay measure migration, transwell chamber inspect capacity. The interaction between predicted...
Chronic kidney disease (CKD) is a common and complex in kidneys which has been associated with an increased risk of renal cell carcinoma. Elevated homocysteine (Hcy) levels are known to influence the development progression CKD by regulating podocyte injury apoptosis. To investigate molecular mechanisms triggered podocytes Hcy, we used cbs
Cholangiocarcinoma (CCA) is a variety of biliary epithelial tumors involving intrahepatic, perihilar and distal bile duct. It the most common malignant duct tumor in liver second primary cancer, whose molecular mechanism not fully understood. Specifically, relationship between CCA chondroitin polymerizing factor (CHPF) still clear. In this study, detection clinical specimens was performed to preliminarily study role CHPF CCA. cells with knockdown were constructed for vitro which also used...
Gastric cancer is one of the most common cancers in world and long noncoding RNAs (lncRNAs) play a crucial role proliferation, metastasis invasion gastric cancer. However, there are very few researches focusing on effects lncRNAs metastatic In this research, we identify kind lncRNA, called AK025387, which highly expressed samples compared with non-metastatic samples. The expression AK025387 significantly positively correlated lymph node metastasis. situ hybridization demonstrates that...
Telomerase is activated in most cancer cells, and thus telomerase an ideal target for therapy. The human liver-associated candidate tumour suppressor LPTS/PinX1, the only protein reported to bind with catalytic subunit reverse transcriptase (TERT) inhibit activity. C-terminal fragment of LPTS/PinX1 (LPTS/PinX1290-328) contains a inhibitory domain that needed inhibition telomere elongation induction apoptosis. This study prepared TAT-LPTS39 (TAT-LPTS/PinX1290-328) polypeptide analysed its...
Abstract Background: Long non-coding RNAs (lncRNAs) have been elucidated to participate in the development and progression of various cancers. In this study, we aim explore underlying functions mechanisms LINC00958 colorectal cancer. Methods: expression cancer tissues was examined by qRT-PCR. The associations between with clinical characteristics prognosis were evaluated. biological detected CCK-8, MTT, colony formation Flow cytometric analyses. RNA-pull down, RIP luciferase reporter assays...
Abstract Radioresistance markedly impairs the efficacy of tumor radiotherapy and involves prosurvival signal transduction pathways that prevent radiation-induced cell death. Nuclear factor-κB (NF-κB), a stress-sensitive heterodimeric transcription factor in regulation stress-responsive genes, has been shown to initiate signaling response ionizing radiation (IR). The cooperative function NF-κB with other key stress elements radioresistance not clearly defined. We have previously reported...
Objection To investigate the effect of miR-32-5p on radiosensitivity, migration and invasion colorectal cancer cells underlying mechanism. Methods Human SW480 normal colonic epithelial NCM460 were cultured. The divided into non-transfected transfected groups (transfected with anti-miR-NC, anti-miR-32-5p, pcDNA, pcDNA-TOB1, anti-miR-32-5p+ si-NC si-TOB1, respectively). expression TOB1 at mRNA protein levels was detected by RT-qPCR Western blot. radiosensitivity determined colony...