A5074815739- Selenium in Biological Systems
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Calpain Protease Function and Regulation
- Retinoids in leukemia and cellular processes
- Biomarkers in Disease Mechanisms
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- Nicotinic Acetylcholine Receptors Study
- Ginseng Biological Effects and Applications
- Innovative Teaching Methods
- Advanced biosensing and bioanalysis techniques
- interferon and immune responses
- Bioinformatics and Genomic Networks
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Ion channel regulation and function
- Curcumin's Biomedical Applications
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Sepsis Diagnosis and Treatment
Jiangsu University
2022-2023
Jinan University
2017-2020
Luohe Medical College
2013-2018
Affiliated Hospital of Hebei University
2016
Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts have been made to elucidate the process of HCC, its molecular mechanisms development remain elusive due complexity. To explore stepwise carcinogenic from pre-neoplastic lesions end stage we employed weighted gene co-expression network analysis (WGCNA) which has proved be an effective method in diseases detect co-expressed modules and hub genes using eight pathological stages including normal, cirrhosis...
The present study aimed to explore the expression of microRNA (miRNA or miR) in drug‑resistant and drug‑sensitive ovarian cancer cell lines, seek potential therapeutic target mechanism order improve drug resistance by altering miRNA levels. characteristics SKOV3/DDP, SKOV3, COC1/DDP COC1 lines were studied. miRNAs that differentially expressed between cisplatin‑resistant cells its parental screened with a chip. effect was detected, their investigated transfection...
Background: Arsenic (As) is a well-known environmental contaminant. Chronic exposure to As known increase the risk of cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and stroke. However, detailed mechanisms by which causes vascular dysfunction involving endothelial integrity permeability unclear. Objectives: Our goal was investigate how leads dysfunction. Methods: trioxide (ATO) used effects using mouse model cultured cell monolayers. Results: Compared with...
To elucidate the mechanism of Spatholobi Caulis (SC) in treating osteoporosis (OP) integrated zebrafish model and bioinformatics.Skeleton staining coupled with image quantification was performed to evaluate effects SC on skeleton mineralization area (SSA) total optical density (TOD). Zebrafish locomotor activity monitored using EthoVision XT. Bioactive compounds their corresponding protein targets were acquired from Traditional Chinese Medicine Systems Pharmacology (TCMSP) database....
Targeting angiogenesis has emerged as a promising strategy for cancer treatment. Methylseleninic acid (MSA) is metabolite of selenium (Se) in animal cells that exhibits anti-oxidative and anti-cancer activities at levels exceeding Se nutritional requirements. However, it remains unclear whether MSA exerts its effects on prevention by influencing within levels. Herein, we demonstrate inhibited 2 µM, which falls the range moderate status. We found treatments µM increased cell adherence, while...
Osteoporosis is a degenerative disease that endangers human health. At present, chemical drugs used for osteoporosis have serious side effects. Therefore, it valuable to search herbs with high safety and good curative effect in antiosteoporosis. Erzhi formula (EZF), an ancient classic compound, has been reported beneficial antiosteoporosis, but its mechanism unclear. In this paper, the active compounds of EZF were found Systems Pharmacology Database, gene targets related obtained GeneCards....
To study the inhibition effect of miR-106a inhibitor on tumor growth ovarian cancer xenografts mice.BALB/c mice were selected as experimental animals, SKOV-3 cells transfected with and its negative control inoculated subcutaneously, intratumoral injection continued after formation, they enrolled treatment group model group, respectively. Tumor volume weight well Ki-67 programmed cell death 4 (PDCD4) expression determined; mimic into cells, PDCD4 in was determined.Tumor tissue mRNA protein...
Arsenic (As) is a well-known environmental pollutant, while arsenic trioxide (ATO) has been proven to be an effective treatment for acute promyelocytic leukemia, however, the mechanism underlying its dual effects not fully understood. Embryonic stem cells (ESCs) exhibit properties of stemness and serve as popular model investigate epigenetic modifiers including pollutants. Herein, low-dose ATO on differentiation were evaluated in vitro using mouse ESCs (mESCs) cell line, CGR8. Cells treated...
Glucocorticoids have been detected in environmental waters, and their biological potency has raised concerns on impact aquatic vertebrates especially fish. Numerous researches showed that the continuous direct contact of with glucocorticoid contaminants water will cause bone formation inhibition. The aim this study is to predict verify effect icaritin (IT), icariin (ICA), baohuside-I (BHG-I) reversing glucocorticoid-induced inhibition (GIBFI) by molecular docking zebrafish model. We...
Biochemistry is an important foundation courses in life science with abstract content.Mind mapping teaching methods introduced biochemistry under the guidance of concept modern education for students.And object to improve students' divergent thinking,induction and memory capacity,and increase their self-learning ability,to teachers' effect learning effect,provide a theoretical basis application mind other courses. Key words: Mind mapping; Biochemistry; Memory ability ; Self-learning
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