A5001365878- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Fluorine in Organic Chemistry
- Hepatitis B Virus Studies
- Computational Drug Discovery Methods
- Microtubule and mitosis dynamics
- Insect and Pesticide Research
- Protein Degradation and Inhibitors
- Neuroscience and Neuropharmacology Research
- Biochemical and Molecular Research
- Insect Resistance and Genetics
- Medical Imaging Techniques and Applications
- Adenosine and Purinergic Signaling
- Viral Infections and Vectors
- Synthesis and biological activity
- Tuberculosis Research and Epidemiology
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Nuclear Receptors and Signaling
- Acute Myeloid Leukemia Research
- Nerve injury and regeneration
- Histone Deacetylase Inhibitors Research
- Neurotransmitter Receptor Influence on Behavior
- Mosquito-borne diseases and control
Baylor College of Medicine
2021-2024
Texas Tech University
2018-2022
Texas Tech University Health Sciences Center
2018-2022
Women Medical College
1970
Highly contagious SARS-CoV-2 coronavirus has infected billions of people worldwide with flu-like symptoms since its emergence in 2019. It caused deaths several million people. The viral main protease (Mpro) is essential for replication and therefore a drug target. Several series covalent inhibitors Mpro were designed synthesized. Structure-activity relationship studies show that (1) chloroacetamide- epoxide-based compounds targeting Cys145 are potent IC50 values as low 0.49 μM (2) Cys44 not...
Dengue (DENV) and Zika (ZIKV) viruses are important human pathogens, causing ∼100 million symptomatic infections each year. These carry a 20-fold increased incidence of serious neurological diseases, such as microcephaly in newborns (for ZIKV) Guillain-Barré syndrome. Moreover, DENV can develop possibly life-threatening dengue hemorrhagic fever certain patients. Patients recovered from one the four serotypes still susceptible to other with higher likelihood disease because antibody-dependent...
The dopaminergic system is involved in the regulation of immune responses various homeostatic and disease conditions. For conditions such as Parkinson's multiple sclerosis (MS), pharmacological modulation dopamine (DA) activity thought to have therapeutic relevance, providing basis for using agents a treatment relevant states. In particular, it was proposed that restoration DA levels may inhibit neuroinflammation. We recently reported new class transporter (DAT) inhibitors with high...
Viral hepatitis is the inflammation of liver caused by viruses. The most common causes viral are five unrelated hepatotropic viruses Hepatitis A, B, C, D, and E. aim this study to assess biochemical parameters in which varies with respect different types hepatitis. Sex patient affected A was almost similar male female, being 9 (45%) 11 (55%) respectively. But contrast, more than eighty per cent (85%) Hepatitis-E population male. Similar scenario found B And C infection (Male- 75%,67%, Female...
Mycolic acids are the key constituents of mycobacterial cell wall, which protect bacteria from antibiotic susceptibility, helping to subvert and escape host immune system. Thus, enzymes involved in regulating biosynthesis mycolic can be explored as potential drug targets kill Mycobacterium tuberculosis (Mtb). Herein, Kyoto Encyclopedia Genes Genomes is used understand fatty acid metabolism signaling pathway integrative computational approach identify novel lead molecules against mtFabH...
Neurodegenerative disorders are continually increasing in incidence due to higher life expectancy. Currently, limited therapeutic strategies available for affected patients, most targeting symptomatic treatment. mTOR pathway is identified as important player neurogenesis that modulates healthy neuron growth and differentiation. Moreover, many neurodegenerative associated with downregulated signaling. However, activation can also lead uncontrolled cell proliferation, promoting cancer. This...
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause 5–10% acute leukemias with poor clinical outcomes. Protein–protein interactions (PPI) between most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rearranged (MLL-r) leukemia. Several benzothiophene-carboxamide compounds were identified as novel inhibitors of these PPIs IC50 values low 1.6 μM. Structure–activity relationship studies 77...
Monoamines, such as dopamine (DA), serotonin (5‐HT) and norepinephrine (NE), have an important modulatory role in neurotransmission the central nervous system (CNS). They are involved numerous physiological functions pathological conditions. Therapeutic application of selective or mixed monoamine transporter (DAT, SERT NET) inhibitors includes a variety neurologic disorders, Parkinson’s disease, Alzheimer’s multiple sclerosis, epilepsy, others. The optimal selectivity profile varies between...