A5090964892- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Gut microbiota and health
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Autophagy in Disease and Therapy
- Heart Rate Variability and Autonomic Control
- Sirtuins and Resveratrol in Medicine
- Telomeres, Telomerase, and Senescence
- Alzheimer's disease research and treatments
- Genetics, Aging, and Longevity in Model Organisms
- Medicinal Plants and Neuroprotection
- Cardiovascular Function and Risk Factors
- Neurogenesis and neuroplasticity mechanisms
- Physical Activity and Health
- Tryptophan and brain disorders
- Genetic and Kidney Cyst Diseases
- Endoplasmic Reticulum Stress and Disease
- Childhood Cancer Survivors' Quality of Life
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Immune responses and vaccinations
- HIV-related health complications and treatments
- Organ Transplantation Techniques and Outcomes
Hungarian School Sport Federation
2022-2025
Center for Health, Exercise and Sport Sciences
2024
University of Tsukuba
2023-2024
Hungarian University of Sports Science
2016-2023
Semmelweis University
2014
Physical fitness is a well-known correlate of health and the aging process DNA methylation (DNAm) data can capture via epigenetic clocks. However, current clocks did not yet use measures mobility, strength, lung, or endurance in their construction. We develop blood-based DNAm biomarkers for parameters gait speed (walking speed), maximum handgrip forced expiratory volume one second (FEV1), maximal oxygen uptake (VO2max) which have modest correlation with five large-scale validation datasets...
Abstract Extracellular vesicles (EVs) are implicated in inter-organ communication, which becomes particularly relevant during aging and exercise. DNA methylation-based clocks reflect lifestyle environmental factors, while regular exercise is known to induce adaptive responses, including epigenetic adaptations. Twenty individuals with High-fitness (aged 57.7 ± 9.8 years) twenty Medium–Low-fitness 57.5 9.7 subjects provided blood samples. EVs were isolated from the samples using a size...
Abstract DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect individual aging process. Here, we examine relationship between physical fitness DNAm-based in adults aged 33–88 with a wide range of (including athletes long-term training history). Higher levels VO 2 max ( ρ = 0.2, p 6.4E − 4, r 0.19, 1.2E 3), Jumpmax 0.11, 5.5E 2, 0.13, 2.8E 2), Gripmax 0.17, 3.5E 3, 0.16, 5.6E HDL 0.18, 1.95E 1.1E 3) associated better verbal...
Abstract Epigenetic clocks can measure aging and predict the incidence of diseases mortality. Higher levels physical fitness are associated with a slower process healthier lifespan. Microbiome alterations occur in various during process, yet their relation to epigenetic is not explored. To fill this gap, we collected metagenomic (from stool), blood), exercise‐related data from physically active individuals and, by applying clocks, examined relationship between gut flora, blood‐based age...
DNA methylation-based age estimators (DNAm ageing clocks) are currently one of the most promising biomarkers for predicting biological age. However, relationships between cardiorespiratory fitness (CRF), measured directly by expiratory gas analysis, and DNAm clocks largely unknown. We investigated CRF age-adjusted value from residuals regression clock to chronological (DNAmAgeAcceleration: DNAmAgeAccel) attempted determine relative contribution DNAmAgeAccel in presence other lifestyle...
Acute mild exercise has been observed to facilitate executive function and memory. A possible underlying mechanism of this is the upregulation ascending arousal system, including catecholaminergic system originating from locus coeruleus (LC). Prior work indicates that pupil diameter, as an indirect marker LC, increases even with very light-intensity exercise. However, it remains unclear whether LC directly contributes exercise-induced pupil-linked arousal. Here, we examined involvement in...
Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced environmental lifestyle factors, whether DNA methylation (DNAm) affected exercise training, remains unclear. In present study, we investigated relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, length (TL) assessed RT-PCR, methylation-based estimation of TL (DNAmTL), biomarkers master rowers (N = 146)...
Abstract Aging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging risk disease. The physiological functions 54 volunteers—including maximal oxygen uptake (VO₂ max), grip strength, vertical jump—were assessed just before pandemic again 3 years later. Of these volunteers, 27 had contracted 19. Eight epigenetic clocks were used assess during 3-year period: DNAmAge showed accelerated aging, five slowed (DNAmAgeSkinBlood, DNAmAgeHannum, DNAmFitAge,...
<title>Abstract</title> In this study, we investigated the potential relationship between mitochondrial network and microbiome using wild-type skeletal muscle-specific PGC-1α (Pparg coactivator 1 alpha) overexpressing mice, both with without exercise training. levels were significantly elevated in muscle and, notably, colon, which is anatomically proximal to microbiome. However, no significant changes observed cell signaling or mitochondria-related proteins within colon. On other hand, H₂O₂...
ABSTRACT Although running upright has been reported to have positive effects on both physical and mental health, the minimum intensity/speed that would benefit mood prefrontal cognition is not yet clear. For this reason, we aimed investigate acute effect of very slow running, which classified as a light intensity exercise, mood, executive function (EF), their neural substrates in cortex (PFC). Twenty-four healthy participants completed 10-minute session treadmill at 35% resting control...
The oxidative stress effect of exercise training on testis function is under debate. In the present study we used a unique rat model system developed by artificial selection for low and high intrinsic running capacity (LCR HCR, respectively) to evaluate effects apoptosis spermatogenesis in testis. Twenty-four 13-month-old male rats were assigned four groups: control LCR (LCR-C), trained (LCR-T), HCR (HCR-C), (HCR-T). Ten key proteins connecting aerobic general testes assessed, including...
Blood flow restriction (BFR) with low-intensity resistance training has been shown to result in hypertrophy of skeletal muscle. In this study, we tested the hypothesis that BFR during rest periods between acute, high-intensity exercise sessions (70% 1 repetition maximum, 7 sets 10 repetitions) enhances effects training.A total healthy young men performed squats, and was carried out on one leg while other served as a control. Because applied periods, even severe occlusion pressure...
Regular exercise can upgrade the efficiency of immune system and beneficially alter composition gastro-intestinal microbiome. We tested hypothesis that active athletes have a more diverse microbiome than sedentary subjects, which could provide better protection against COVID-19 during infection. Twenty competing (CA) (16 male 4 females national first second leagues), aged 24.15 ± 4.7 years, 20 subjects (SED) (15 5 females), 27.75 7.5 who had been diagnosed as positive for by PCR test, served...
(1) Background: Higher levels of physical fitness are believed to increase the physiological quality life and impact aging process with a wide range adaptive mechanisms, including regulation expression age-associated klotho (KL) gene protein levels. (2) Methods: Here, we tested relationship between DNA methylation-based epigenetic biomarkers PhenoAge GrimAge methylation promoter region KL gene, circulating level KL, stage grip force in two groups volunteer subjects, trained (TRND) sedentary...
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage strategy to induce rapid regeneration of the remnant liver. The technique has been associated with high mortality morbidity rates. This study aimed evaluate mitochondrial function, biogenesis morphology during ALPPS-induced regeneration.Male Wistar rats (n = 100) underwent (PVL) or ALPPS. animals were killed at 0 h (without operation), 24, 48, 72 168 after intervention. Regeneration rate...
Despite the intensive investigation of molecular mechanism skeletal muscle hypertrophy, underlying signaling processes are not completely understood. Therefore, we used an overload model, in which main synergist muscles (gastrocnemius, soleus) plantaris were surgically removed, to cause a significant remaining 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic pathways, NAD and H2S levels this overload-induced hypertrophy studied. Fourteen days resulted 43% (p < 0.01)...
Abstract Background It has been suggested that exercise training and postbiotic supplement could decelerate the progress of functional biochemical deterioration in double transgenic mice overexpresses mutated forms genes for human amyloid precursor protein (APP sw ) presenilin 1 (m146L) (APP/PS1 TG ). Our earlier published data indicated performed better than controls on Morris Maze Test parallel with decreased occurrence amyloid-β plaques hippocampus. We investigated neuroprotective...
ABSTRACT Purpose Growing concern exists worldwide about stress-related mental disorders, such as posttraumatic stress disorder (PTSD), often linked to hippocampal dysfunctions. Recognizing this connection, regular light-intensity exercise (LIE)—such yoga, walking, or slow jogging—may offer a solution. Easily accessible even vulnerable individuals, LIE has been found enhance hippocampus-based cognitive functions through the stimulation of neurotrophic factors like brain-derived factor (BDNF)....
Abstract Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases ageing, affecting hundreds of millions people. Elucidation pathophysiological mechanisms, as well effective treatments muscle represents an important goal improving human health. Here, we show that phosphatidylethanolamine cytidyltransferase (PCYT2/ECT), critical enzyme Kennedy branch (PE) synthesis pathway, has essential role Human genetic deficiency PCYT2 causes a severe disease with...
Abstract DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm) based biomarkers that reflect individual aging process. Furthermore, physical fitness is known to relate process, but its relationship gut microbiome has not yet been studied. Here, we examine among fitness, DNAm biomarkers, in adults aged 33-88 with a wide range of (including athletes long-term training history). Higher levels VO2max (ρ=0.2, p=6.4E-4, r=0.19, p=1.2E-3), Jumpmax p=0.11,...