A5103238194- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Cardiac electrophysiology and arrhythmias
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Mobile Agent-Based Network Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuropeptides and Animal Physiology
- Electrolyte and hormonal disorders
- HER2/EGFR in Cancer Research
- Coccidia and coccidiosis research
- Food Allergy and Anaphylaxis Research
- Cancer, Stress, Anesthesia, and Immune Response
- Botulinum Toxin and Related Neurological Disorders
- Biomimetic flight and propulsion mechanisms
- Airway Management and Intubation Techniques
- Pharmacological Effects of Natural Compounds
- Spine and Intervertebral Disc Pathology
Kochi Medical School Hospital
2016-2025
Kōchi University
2014-2025
Mie University
2007-2023
Bunka Gakuen University
2019-2022
Hiroshima Bunka Gakuen University
2019-2022
East Japan Railway (Japan)
2009-2017
Tokushima University
1988-2016
Kagoshima University
2012
Medical College of Wisconsin
2009-2010
Kyushu Institute of Technology
2009
Abstract Background: Sustained neuroinflammation may contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Here, authors evaluated preventive effect preoperative environmental enrichment (PEE) on development and concomitant POCD in a rat abdominal surgery model. Methods: Young aged rats were assigned one four groups using 2 × experimental design: PEE versus sedentary condition for 14 days, by anesthesia alone (n = 8 each group). After 7-day postsurgical recovery...
Diagnosis of perioperative anaphylaxis is often challenging. This study describes the utility a newly developed tool for identifying patients with high possibility anaphylaxis, and aimed to investigate frequency each drug during period in Japan.This included Grade 2 or higher severity general anaesthesia at 42 facilities across Japan 2019 2020. We adopted unique objective evaluation yielding composite score diagnosing which includes results skin tests basophil activation tests, clinical...
ATP-sensitive potassium (KATP) channels in neurons regulate excitability, neurotransmitter release and mediate protection from cell-death. Furthermore, activation of KATP is suppressed DRG after painful-like nerve injury. NO-dependent mechanisms modulate both participate the pathophysiology pharmacology neuropathic pain. Therefore, we investigated NO modulation control axotomized neurons.Cell-attached cell-free recordings currents large rats (sham surgery, SS) revealed by exogenously...
Background Volatile anesthetics impair insulin secretion and glucose utilization; however, the precise mechanism of action that underlies these effects is unknown. The authors hypothesized isoflurane inhibits glucose-induced inhibition adenosine triphosphate-sensitive potassium channel activity in pancreatic beta cells, which could result impaired tolerance. Methods Intravenous tolerance tests were performed on 28 male Japanese White rabbits anesthetized with sodium pentobarbital....
Background: ATP-sensitive potassium (K ATP ) channels in neurons mediate neuroprotection, they regulate membrane excitability, and control neurotransmitter release. Because loss of DRG neuronal K currents is involved the pathophysiology pain after peripheral nerve injury, we characterized distribution channel subunits rat DRG, determined their alterations by painful axotomy using RT-PCR, immunohistochemistry electron microscopy. Results: PCR demonstrated Kir6.1, Kir6.2, SUR1 SUR2 transcripts...
Painful axotomy decreases K(ATP) channel current (IK(ATP)) in primary afferent neurons. Because cytosolic Ca(2+) signaling is depressed injured dorsal root ganglia (DRG) neurons, we investigated whether Ca(2+)-calmodulin (CaM)-Ca(2+)/CaM-dependent kinase II (CaMKII) regulates IK(ATP) large DRG Immunohistochemistry identified the presence of subunits SUR1, SUR2, and Kir6.2 but not Kir6.1, pCaMKII neurofilament 200-positive somata. Single-channel recordings from cell-attached patches revealed...
In order to ascertain the effects of epidermal growth factor (EGF) on human cancer invasion abilities, three cell lines oral squamous carcinoma were studied using a phagokinetic track assay and zymography. EGF (1-100 ng/ml) was found inhibit but enhance random motility all in concentration-dependent fashion. Exposure EGF, dose-dependently, led an increased production urokinase-type plasminogen activator M(r) 92 kD matrix metalloproteinase by same cells. These results strongly suggest that...
The cellular mechanisms of neuropathic pain are inadequately understood. Previous investigations have revealed disrupted Ca signaling in primary sensory neurons after injury. authors examined the effect injury on intracellular stores endoplasmic reticulum, which critically regulate signal and neuronal function.
The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect resveratrol (RESV) for POCD rats. emulsified form RESV (e-RESV) was selected improve its oral brain bioavailability. Animals were assigned one four groups: e-RESV (80 mg/kg) versus vehicle treatment by abdominal isoflurane anesthesia alone (n = 8 each group). dose-dependent effects also dose...
Both propofol and thiamylal inhibit adenosine triphosphate-sensitive potassium (KATP) channels. In the current study, authors investigated effects of these anesthetics on activity recombinant sarcolemmal KATP channels encoded by inwardly rectifying channel (Kir6.1 or Kir6.2) genes sulfonylurea receptor (SUR1, SUR2A, SUR2B) genes.The used inside-out patch clamp configurations to investigate using COS-7 cells transfected with various types subunits.Propofol inhibited activities SUR1/Kir6.2...
Sarcolemmal adenosine triphosphate-sensitive potassium (KATP) channels in the cardiovascular system may be involved bupivacaine-induced toxicity. The authors investigated effects of local anesthetics on activity reconstituted KATP encoded by inwardly rectifying channel (Kir6.0) and sulfonylurea receptor (SUR) subunits.The used an inside-out patch clamp configuration to investigate bupivacaine, levobupivacaine, ropivacaine expressed COS-7 cells containing wild-type, mutant, or chimeric...