A5036016063- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Biochemical effects in animals
- Memory and Neural Mechanisms
- Trace Elements in Health
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Medicinal Plants and Neuroprotection
- Pharmacological Effects and Toxicity Studies
- Sesame and Sesamin Research
- Neurological Disorders and Treatments
- Fatty Acid Research and Health
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Heavy Metal Exposure and Toxicity
- Human Health and Disease
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Chromatography in Natural Products
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
Shahid Chamran University of Ahvaz
2014-2023
Stem Cell Technology Research Center
2019-2023
Ahvaz Jundishapur University of Medical Sciences
2017
Traditional herbal medicines such as Petroselinum crispum (Parsley) have been used for treatment of intestinal disorders in Iran. To date no pharmacological evidence their effectiveness has reported. The aim this study was to examine the relaxant effect hydroalcoholic extract on isolated adult male Wistar rat's ileum contraction by KCl 60 (mM). prepared from parsley seed with 80% ethanol. A portion removed and placed an organ bath containing Tyrode solution (37 degrees C, pH = 7.4) bubbled...
Objective . Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects LFS with same applied either just before or immediately after kindling stimulations. Method This experimental animal was conducted on adult Wistar rats (200 ± 20 g) randomly divided into kindle (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn...
Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer's Disease (AD). The current study aimed at evaluating effect donepezil hydrochloride on pyramidal neuron response CA1 region a rat model AD.In experimental study, adult male Wistar rats were randomly divided into four groups: Nucleus Basalis Magnocellularis (NBM) lesion (the lesions induced by electrical method 0.5 m A, for 3 s NBM) and three groups (lesions plus 5, 10, 15 mg/kg...
Despite the chronic effects of nandrolone decanoate (ND), acute ND on passive avoidance learning (PAL) and memory its mechanism have not been investigated. This research examines effect PAL, CA1 synaptic plasticity, testosterone corticosterone serum levels, role androgenic receptors (ARs). Adolescent male rats were treated with ND, 30 min before training retention after test. AR antagonist was applied 15 ND. Hippocampal slices perfused by administration had an inverted U-shape acquisition...
Background and Objective: Developing quantitative measures based on spectral analysis of electroencephalograph (EEG) recordings neural activities plays an important role in developing efficient treatments for epilepsy. Such biomarkers can be used open or closed loop approaches seizure prediction prevention. This study aims to quantitatively evaluate antiepileptogenic effects low frequency stimulation (LFS) applied immediately before after kindling stimulations using power extracellular EEG...
The aim of the present study was to evaluate effects dose-dependent zinc chloride on short-term and long-term memory in a shuttle box. Young Wistar rats (94+/-10 g) (age 27-30 days) consumed drinking water five different doses (20, 30, 50, 70 100 mg kg(-1) day(-1)) for two weeks by gavage. After 14 days experimental diets, box used test short- memory. Two criteria considering behavioral test, including latency entering dark chamber time spent chamber. This experiment shows that after 2 oral...
The aim of the present study is for evaluating effect different doses palmitic acid on spatial learning in T-maze. So, Wister adult male rats were used five groups and considered 10 each group. first group as a control was fed with ordinary diet. Four diet containing (10%) 1, 2, 3 4 weeks, then trained task by using T-maze at subsequently 9 days based standard method. result showed that, increased 10% 2 weeks significant (p<0.05). However, dietary because via palmitoylation modifies numerous...
The aim of present study was to investigate the effect hydroalcoholic extract Ruta chalepensis (Rutaceae) leaves on rat ileum contractility and possible mechanism(s) involved. prepared by maceration method (ethanol 70%). Terminal portion (2 cm) dissected out from male Wistar rats mounted in an organ bath containing air bubbled Tyrode solution with 1 g initial tension ileal contraction induced KCl (60 mM) recorded. spasmolytic cumulative concentrations extracts (0.01-0.07 mg mL(-1)) reduced...
In this study, the effects of oleic acid (10%) and palmitic on spatial learning motor activity have been investigated. So, adult male Wister rats divided into four groups (n=10). Control group was fed with ordinary diet. other were a diet containing for 4 weeks or 1 week. Also, coadministration plus next step, trained task by using T-maze at subsequently 9 days. Moreover, tested Rota rod based standard method. The results showed that significantly (p < 0.01, p 0.001) increased in weeks. Also...
Memantine (MEM) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically used for the treatment of Alzheimer disease (AD) in mild to severe conditions. The present study was conducted investigate effects memantine on spontaneous firing frequency CA1 pyramidal neurons rats caused by an electrical lesion Nucleus Basalis Magnocellularis (NBM). Then, this model AD compared with intact adult male rats.In study, were divided into two groups. Group I (lesion NBM, n=53)...