Abstract Gastric ulcers are a type of digestive disease that can severely affect person's quality life. Our study aimed to investigate the effects fish oil on ethanol-induced gastric in rats, with purpose providing more comprehensive information topic. The looked at various factors such as ulcer index, and nitric oxide (NO) levels stomach tissue. To apoptosis, mRNA Bax, Bcl-2, Caspase 3 were analyzed. results showed reduce acidity index cases ulcers. It was found increase NO improve...

Abstract Neonatal hypoxia has a negative impact on the developing brain during sensitive period. Inflammation plays key role in physiological response to hypoxic stress. Considering anti-inflammatory properties of alpha-pinene, which received lot attention recent years, this research we focused alpha-pinene behavioral responses and proinflammatory factors rats subjected neonatal hypoxia. This study involved Wistar (7-day-old) that were divided into six experimental groups, including control...

Febrile seizures are common in children and can lead to neurological deficits like motor impairments, memory problems, cognitive decline. Research on dimethyl itaconate aims mitigate these effects improve the quality of life for affected people. By exploring its potential as a protective agent against oxidative stress during seizures, this study adult male rats measures activity key enzymes related behavioral performance. Pregnant were divided into control, sham, DMI, febrile seizure, DMI +...

Abstract Introduction Spinal cord injury (SCI) leads to inflammation, axonal degeneration, and gliosis. A combined treatment of exercise neural stem cells (NSC) has been proposed improve repair. This study evaluated a high‐intensity interval training (HIIT) with NSC generation from adipose‐derived (ADSCs) on contusive model SCI in rats. Materials Methods In vitro, rat ADSCs were isolated the perinephric regions Sprague–Dawley rats using enzymatic digestion. The transdifferentiated into...

Maternal hypoxia disrupts neural development and subsequently leads to cerebral palsy epilepsy in newborns. Hypoxia plays a role neurodegeneration by increasing oxidative stress. Pistacia atlantica is known as an important antioxidant, its anti-inflammatory antioxidant effects have been shown various studies. This study aims investigate the of methanolic extract P. leaves (MEPaLs) on parameters serum rats affected maternal hypoxia.

Objective . Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects LFS with same applied either just before or immediately after kindling stimulations. Method This experimental animal was conducted on adult Wistar rats (200 ± 20 g) randomly divided into kindle (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn...

Abstract Introduction Neonatal hypoxia leads to cognitive and movement impairments that might persist throughout life. Hypoxia impairs hippocampal blood circulation metabolism. The exact mechanisms underlying hypoxia‐induced memory impairment are not fully understood. Nitric oxide (NO) is a key neuromodulator regulates cerebral flow. In this study, we aimed evaluate the possible role of NO on behavioral histomorphometric changes in hippocampus following neonate rats. Material methods Neonate...

Gamma-linolenic acid (GLA) is found in animals and plants that play a role brain function metabolism.

Background and Objective: Developing quantitative measures based on spectral analysis of electroencephalograph (EEG) recordings neural activities plays an important role in developing efficient treatments for epilepsy. Such biomarkers can be used open or closed loop approaches seizure prediction prevention. This study aims to quantitatively evaluate antiepileptogenic effects low frequency stimulation (LFS) applied immediately before after kindling stimulations using power extracellular EEG...

Abstract Introduction Brain hypoxia has important role to the onset and progression of sporadic form Alzheimer disease via expression hypoxia‐inducible factor‐1 (HIF‐1). Crocin by anti‐amyloidogenic property inhibits β‐amyloid formation. However, molecular mechanism associated with activity crocin is unknown. So, present study was designed investigate effect on cognitive behavior HIF‐1α β‐secretase (BACE1) genes in brain neonate rats following different intensities during pregnancy. Material...

The aim of the present study was to evaluate effects dose-dependent zinc chloride on short-term and long-term memory in a shuttle box. Young Wistar rats (94+/-10 g) (age 27-30 days) consumed drinking water five different doses (20, 30, 50, 70 100 mg kg(-1) day(-1)) for two weeks by gavage. After 14 days experimental diets, box used test short- memory. Two criteria considering behavioral test, including latency entering dark chamber time spent chamber. This experiment shows that after 2 oral...

Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication characterized by many side effects. Coenzyme Q10 (CoQ10) a protective lipophilic molecule with extensive range of biological functions, but its possible effect on the ovary in OHSS has not as yet been studied. The present study aimed to investigate potential effects CoQ10 ovarian histological and molecular alterations experimental model rats.Thirty female (2 months old) Wistar rats were randomly divided into 6 equal...

Abstract Background Multiple sclerosis (MS) is the most common autoimmune disease. Progressive depletion of brain and spinal cord tissue appears at onset Several studies have shown increased size ventricles decreases in area corpus callosum width brain. Other important symptoms this disease are cognitive, learning, memory disorders. Aim The aim study was to compare morphometric, histological, functional changes demyelination model both sexes. Materials methods In experimental study, male...

Brain injury is one of the most important causes infant mortality and chronic neurological disabilities. Hypoxia an acute brain which led to various cognitive, behavioral, memory disorders throughout life. Previous studies reported neuroprotective possibilities for fish oil (FO) in brain-injured situations. In this study, we evaluated effect FO diet during lactation period on seizure activity, behavioral performance, histomorphometry, inflammatory changes brains hypoxia rats. Male Wistar...

Hypoxia-Induced Neonatal Seizure (HINS) is a prevalent type of seizure in infants caused by hypoxic conditions, which can lead to an increased risk epilepsy, learning disabilities, and cognitive impairments later life. This study focuses on examining the effects dimethyl itaconate (DMI) cognition, motor coordination, anxiety-like behavior male rats that have experienced HINS. 42 Wistar newborn (PND10) were randomly divided into six groups (n = 7). 1) Control (Vehicle only); received DMI...

Hypoxia via expression of Hypoxia-Inducible Factor-1 (HIF-1) is an important and effective factor in the onset progression memory disorders, such as Alzheimer Disease (AD). The activity β-secretase (BACE1) increased hypoxia conditions. BACE1 triggers a cascade pathological events resulting AD. Crocin acts memoryimproving agent but its molecular mechanism not well-known. Therefore, this study, effect crocin on spatial memory, HIF-1α, gene was investigated rat offspring under maternal...