A5103069407- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Icing and De-icing Technologies
- Surface Modification and Superhydrophobicity
- Immune Response and Inflammation
- Aerodynamics and Fluid Dynamics Research
- Heat transfer and supercritical fluids
- Mitochondrial Function and Pathology
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Aerospace Engineering and Energy Systems
- Inflammasome and immune disorders
- Barrier Structure and Function Studies
- Neurological Disorders and Treatments
- Nuclear Engineering Thermal-Hydraulics
- Fluid Dynamics and Heat Transfer
- Catalysts for Methane Reforming
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Medicinal Plants and Neuroprotection
- Curcumin's Biomedical Applications
- Nuclear Receptors and Signaling
- Wireless Power Transfer Systems
- Advanced Sensor and Energy Harvesting Materials
- Innovative Energy Harvesting Technologies
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Beihang University
2022-2023
The First People's Hospital of Xiaoshan District, Hangzhou
2021
Shanghai Fudan Microelectronics (China)
2019-2020
Fudan University
2011-2020
Xiamen University
2017-2018
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016
Chongqing Medical University
2016
First Affiliated Hospital of Wannan Medical College
2008
Centre International de Recherche sur le Cancer
2008
Neuroinflammation has been demonstrated to be linked with Parkinson's disease (PD), Alzheimer's disease, and cerebral ischemia. Our previous investigation had identified that kaempferol (KAE) exerted protective effects on cortex neuron injured by LPS. In this study, the possible mechanism of KAE striatal dopaminergic neurons induced LPS in mice were further investigated. The results showed improved injury, increased levels tyrosine hydroxylase (TH) postsynaptic density protein 95 (PSD95)...
Kaempferol has been reported to act as an anti-inflammatory agent in LPS-induced neuroinflammation vitro and vivo, but its role the inflammation after cerebral ischemia/reperfusion (I/R) is unclear. The present study was investigate effect of kaempferol on ischemic brain tissue explore mechanisms I/R rats. Cerebral rat model established by middle artery occlusion for 60 min following reperfusion. at doses 25, 50 100 mg/kg administered 7 days I/R. treatment significantly reduced infarct...
Myricitrin, a bioactive and natural flavonoids, is well known for its anti-inflammatory antioxidant properties. However, the anti-neuroinflammation possible mechanism has not been fully elucidated. Therefore, present study was to investigate of neuroprotection in nigrostriatum LPS-stimulated mice. The results showed that myricitrin improved neuron injury raised expressions PSD-95 protein TH In addition, decreased production pro-inflammatory factors including IL-1β, IL-6 TNFα, level chemokine...
Chrysomycin A (Chr-A), an antibiotic chrysomycin, was discovered in 1955 and is used to treat cancer tuberculosis. In the present study, anti-neuroinflammatory effects possible mechanism of Chr-A BALB/c mice BV2 microglia cells stimulated by lipopolysaccharide (LPS) were investigated. Firstly, cortex tissues analyzed RNA-seq transcriptome identify differentially expressed genes (DEGs) regulated LPS-stimulated mice. Inflammatory cytokines inflammatory proteins detected enzyme-linked...
The aberrant expression of circular RNAs (circRNAs) plays vital roles in the advancement human cancers, including gastric cancer (GC). In this study, functions circRNA ring finger protein 111 (circ-RNF111) GC were investigated.Quantitative real-time polymerase chain reaction (qRT-PCR) assay was performed for levels circ-RNF111, microRNA-876-3p (miR-876-3p) and krueppel-like factor 12 (KLF12) mRNA. RNase R conducted feature circ-RNF111. Cell Counting Kit-8 (CCK-8) assay, colony formation...
Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions attenuate cerebral ischemic injury. However, global protein profile signaling conduction pathways regulated by are still unclear. This study established a two-vessel occlusion rat model bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg for 4 consecutive weeks. Learning memory abilities measured with Morris...
In this paper, DC and AC performance of junctionless MOSFETs are extensively examined. A comparison is made between double-gate conventional inversion-mode with an emphasis on the variability in performance. Despite clear benefits by eliminating junctions related junction variabilities, found to require double- or multi-gate order be fully turned off. They also significantly more sensitive variations channel thickness doping concentration. Though demonstrate lower driving current...
Background: As a substrate of apoER2, Reelin has been verified to exert neuroprotection by preventing memory impairment. Pinocembrin is the most abundant natural flavonoid found in propolis, and it used neuroprotection, blood–brain barrier protection, anti-oxidation, inflammation diminishing, both vitro vivo. However, roles molecular mechanisms pinocembrin neurobehavioral outcomes neuronal repair after vascular dementia are still under investigation. Purpose: To explore role involvement...
AIM:To explore the correlation between mRNAs and protein expression of gastrin (GAS), somatostatin (SS) apoptosis index (AI), regulation gene Fas/ FasL caspases in large intestinal carcinoma (LIC).
RKC-B1 is a novel fermentation product obtained from the marine micromonospora FIM02-523A. Thus far, there have been few reports about pharmacological activity of RKC-B1. In our present study, we investigated anti-neuroinflammatory effects and possible mechanism in LPS-stimulated mice. After treatment with RKC-B1, RNA-seq transcriptome cerebral cortex tissue was conducted to find differentially expressed genes (DEGs). Inflammatory cytokines proteins were evaluated by ELISA WB. analysis, 193...