A5059680407- Pharmaceutical studies and practices
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Clinical Nutrition and Gastroenterology
- Antibiotics Pharmacokinetics and Efficacy
- Safe Handling of Antineoplastic Drugs
- Anesthesia and Sedative Agents
- Iron Metabolism and Disorders
- Pharmaceutical Practices and Patient Outcomes
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Viral gastroenteritis research and epidemiology
- Educational and Social Studies
- Acute Myeloid Leukemia Research
- Oral health in cancer treatment
- Neonatal Respiratory Health Research
- Glioma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Methemoglobinemia and Tumor Lysis Syndrome
- Nausea and vomiting management
- Dental Anxiety and Anesthesia Techniques
- Diverse academic and cultural studies
IRCCS Materno Infantile Burlo Garofolo
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021
University of Trieste
2013-2021
University of Ferrara
2021
Ospedale Sacro Cuore Don Calabria
2021
University of Padua
2005-2007
Abstract Objectives To demonstrate the efficacy of laser photobiomodulation (PBM) compared to that placebo on severe oral mucositis (OM) in pediatric oncology patients. The primary objective was reduction OM grade (World Health Organization [WHO] scale) 7 days after starting PBM. Secondary objectives were pain, analgesic consumption, and incidence side effects. Methods One hundred one children with WHO > 2 chemotherapy‐induced enrolled eight Italian hospitals. Patients randomized either...
Alternating hemiplegia of childhood (AHC) is a rare neurological disorder that usually manifests before 18 months age and characterized by recurrent, alternating episodes hemiparesis with variable frequency can last from few minutes to several days. We present case AHC in little girl carrying sporadic mutation the ATP1A3 gene (p.Glu815Lys) refractory flunarizine non-compliant topiramate due adverse effects treated oral compound adenosine-5'-triphosphate (ATP) capsules. Outcome was evaluated...
Purpose To determine if hepatic gadolinium deposition occurs in pediatric patients with iron overload but normal renal and function who undergo gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance (MR) imaging. Materials Methods Design execution of this study was approved by the Ethical Committee Institute for Research Maternal Child Health Burlo Garofolo Trieste (reference no. 1105/2015). Because retrospective nature study, requirement to obtain informed consent waived....
<h3>Objectives</h3> To assess the effectiveness of sublingual ketorolac versus tramadol in reducing pain associated with fracture or dislocation extremities children. <h3>Patients and methods</h3> A double-blind, randomised, controlled, non-inferiority trial was conducted paediatric emergency department a research institute. One hundred thirty-one children aged 4–17 years suspected bone were enrolled. Eligible randomised to (0.5 mg/kg) placebo, (2 placebo by administration, using...
The use of antiemetics for vomiting in acute gastroenteritis children is still a matter debate. We conducted double-blind randomized trial to evaluate whether single oral dose ondansetron vs domperidone or placebo improves outcomes with gastroenteritis. After failure initial rehydration administration, aged 1–6 years admitted the pediatric emergency departments 15 hospitals Italy were receive one (0.15 mg/kg) (0.5 placebo. primary outcome was percentage receiving nasogastric intravenous...
Although it has been demonstrated that European roe deer ( Capreolus capreolus (L. 1758)) may migrate seasonally in areas with snow gradients, this behaviour remains scarcely understood. From 1999 to 2002, radio-tracking techniques an Italian alpine area showed 40% of the 32 monitored migrated (12.0 ± 6.2 km, mean SD) from high-elevation summer ranges low-elevation winter ranges. Proportions migratory were similar for fawns and adults males females. We documented a mixed migration strategy,...
Background. Intravenous glutamine-enriched solution seems to be effective in posttransplant period decreasing the severity and duration of mucositis. The aim this randomized study was determine benefit glutamine supplementation both on mucosal morbidity associated complications. Methods. Children undergoing allogeneic hematopoietic stem-cell transplantation (HSCT) for malignant hematological diseases were randomly assigned standard total parenteral nutrition (S-TPN) or (GE)-TPN consisting...
Background Immune checkpoint inhibitors such as nivolumab and targeted BRAF have dramatically altered the treatment outcomes of metastatic melanoma over past few years. Skin toxicity is most common adverse event (AE) related to commonly used inhibitor vemurafenib, affecting more than 90% patients. Vemurafenib-related severe AEs with early onset are reported in patients who were previously treated anti-programmed cell death-1 (anti PD-1) antibodies. A prolonged administration systemic...
Acute graft-versus-host disease (GVHD) is a common life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), ranking as the second leading cause death among recipients, surpassed only by relapse. Tacrolimus commonly used for GVHD prophylaxis, but achieving therapeutic blood levels challenging, particularly in pediatrics, due to narrow window and high interindividual variability. The retrospective study conducted at IRCCS "Burlo Garofolo" Italy aimed...
Vomiting in children with acute gastroenteritis (AG) is not only a direct cause of fluid loss but it also major factor failure oral rehydration therapy (ORT). Physicians who provide care to paediatric patients the emergency department (ED) usually prescribe intravenous (IVT) for mild or moderate dehydration when vomiting symptom. Thus, effective symptomatic treatment would lead an important reduction use IVT and, consequently, duration hospital stay and frequency admission. Available...
Background: Children with medical complexity need complex assistance, that considerably affects caregivers’ quality of life. They often multiple medications, a consequent relevant risk errors or poor compliance. Galenic (or compounded) drugs are blended in the pharmacy’s laboratory worldwide according to different rules and tailoring patient’s needs. While their use may sometimes simplify these therapies, little is known about parents’ attitude this issue. Aim: This study aimed at...
Conclusion. Nuclear expression of survivin should be studied as a promising marker higher-risk laryngeal basaloid squamous cell carcinomas (BSCCs), which can then treated more aggressively and followed closely. Objective. BSCC is an uncommon bimorphic variant SCC. The hypothesized greater aggressiveness poorer prognosis head neck compared to SCC are still under debate. regulation apoptotic death has profound effect on the pathogenesis progression malignancies. Survivin smallest member...
Tigecycline is the first available drug of glycylcycline family. Because recent introduction, some its adverse effects could be still unexplored.We report cases 2 boys who underwent an allogenic bone marrow transplantation for acute myeloid leukemia and were treated with tigecycline. Erythrocyte platelet engraftment followed a normal course, but neutrophil count remained low despite increase in leukocyte count. After tigecycline interruption, rapidly raised both cases.Neutropenia was...
The medical records of 44 pediatric patients who underwent allogeneic transplantation from 2011 to 2015 were retrospectively reviewed. Magnetic resonance imaging was used measure iron concentrations in the liver, spleen, pancreas and bone. These divided into two groups, 18 with non-elevated (< 100 μmol/g; Group 1) liver concentration before 26 elevated (> 2) . We compared transplant-related outcomes groups. Iron overload a negative prognostic risk factor for sinusoidal obstruction syndrome...
Abstract Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also detected in normal tissues of patients the blood healthy donors. This report documents new association Stevens–Johnson syndrome, rare immune‐modulated mucocutaneous process particularly specific drugs infective agents. A high viral load was simultaneously...
Evinacumab, a human monoclonal antibody against angiopoietin-like protein 3 (ANGPTL3), has recently been approved by U.S. Food and Drug Administration as an add-on therapy for homozygous familial hypercholesterolemia (HoFH) in patients of 12 years older. Its role triglyceride-lowering drug is also emerging the literature. However, it not this indication yet, neither adult nor pediatric population. We describe case 10-year-old boy who underwent allogeneic hematopoietic stem cell transplant...
Acute graft-versus-host disease (GvHD) remains the second leading cause of death, after relapse, in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The medical records 112 pediatric who underwent allo-HSCT from matched unrelated and haploidentical donors were analyzed. Patients divided into two groups, according to GvHD prophylactic regimen used. In control group, prophylaxis consisted cyclosporine A (CsA) methotrexate (MTX) or CsA mycophenolate mofetil...
Abstract Background Describe the efficacy of a galenic glycopyrrolate formulation and its impact on patients with sialorrhea Quality Life (QoL), including costs analysis. Methods We performed retrospective observational study 21 who received custom-formulated syrup for an average period 14.3 months. analyzed telephone interviews elaborated validated questionnaires therapy comparing brand marketed drug formulation. Results Overall, 16 out (76.2%) reported significant improvement in QoL. In 14...