A5059150956- Global Maternal and Child Health
- Global Health Care Issues
- Global Public Health Policies and Epidemiology
- Health disparities and outcomes
- Infant Development and Preterm Care
- Climate Change and Health Impacts
- Inflammatory Bowel Disease
- Pediatric Pain Management Techniques
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Breastfeeding Practices and Influences
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Advanced Breast Cancer Therapies
- Child Nutrition and Feeding Issues
- Child Nutrition and Water Access
- Maternal and Perinatal Health Interventions
- Cognitive and developmental aspects of mathematical skills
- Health Systems, Economic Evaluations, Quality of Life
- Reading and Literacy Development
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Trauma and Emergency Care Studies
- Central Venous Catheters and Hemodialysis
Centro di Riferimento Oncologico
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2025
IRCCS Materno Infantile Burlo Garofolo
2012-2023
Ospedale di Cattinara
2022
Sorbonne Université
2019
Hôpital Charles-Foix
2019
Assistance Publique – Hôpitaux de Paris
2019
University of Trieste
2008-2017
Madda Walabu University
2015
Association of Maternal and Child Health Programs
2012
IMPORTANCECancer is among the leading causes of death worldwide.Current estimates cancer burden in individual countries and regions are necessary to inform local control strategies.OBJECTIVE To estimate mortality, incidence, years lived with disability (YLDs), life lost (YLLs), disability-adjusted life-years (DALYs) for 28 cancers 188 by sex from 1990 2013. EVIDENCE REVIEWThe general methodology Global Burden Disease (GBD) 2013 study was used.Cancer registries were source incidence data as...
Although the causes of dyslexia are still debated, all researchers agree that main challenge is to find ways allow a child with read more words in less time, because reading undisputedly most efficient intervention for dyslexia. Sophisticated training programs exist, but they typically target component skills reading, such as phonological awareness. After have improved, remains (that is, deficits must be treated by more—a vicious circle dyslexic child). Here, we show simple manipulation...
There is some evidence for a role of music training in boosting phonological awareness, word segmentation, working memory, as well reading abilities children with typical development. Poor performance tasks requiring temporal processing, rhythm perception and sensorimotor synchronization seems to be crucial factor underlying dyslexia children. Interestingly, show deficits both language music. Within this framework, we test the hypothesis that training, by improving processing abilities,...
Abstract Background It is crucial to identify in large population samples the most important determinants of excessive fetal growth. The aim study was evaluate independent role pre-pregnancy body mass index (BMI), gestational weight gain and diabetes on risk macrosomia. Methods A prospective collected data mode delivery maternal/neonatal outcomes eleven Hospitals Italy. Multiple pregnancies preterm deliveries were excluded. sample included 14109 women with complete records. Associations...
Background The relative role of socioeconomic status (SES), home environment and maternal intelligence, as factors affecting child cognitive development in early childhood is still unclear. aim this study to analyze the association SES, IQ with neurodevelopment at 18 months. Methods data were collected prospectively PHIME study, a newborn cohort carried out Italy between 2007 2010. Maternal nonverbal abilities (IQ) evaluated using Standard Progressive Matrices, version Raven's Matrices;...
Rhythm organizes events in time and plays a major role music, but also the phonology prosody of language. Interestingly, children with developmental dyslexia-a learning disability that affects reading acquisition despite normal intelligence adequate education-have poor rhythmic perception. It has been suggested an accurate perception rhythmical/metrical structure, requires rise time, may be critical for phonological development subsequent literacy. This hypothesis is mostly based on results...
Abstract Background In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated significant morbidity and mortality. Severe dysregulated systemic inflammation the putative mechanism. We hypothesize that early prolonged methylprednisolone (MP) treatment could accelerate resolution, decreasing need for intensive care unit (ICU) admission Methods conducted a multicenter...
Importance Various randomized trials have explored the efficacy of combining immune checkpoint inhibitors (ICIs) with first-line chemotherapy in advanced endometrial cancer. We aimed to summarize available data and clarify benefit adding immunotherapy according DNA mismatch repair status (deficient, dMMR or proficient, pMMR) specific type agent used (anti-PD1 anti-PD-L1). Objective To assess whether addition ICIs standard platinum-based enhances progression-free survival (PFS) for patients...
Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead permanent impairments. Few trials have evaluated new drugs for refractory in children.To determine whether thalidomide effective inducing remission pediatric disease.Multicenter, double-blind, placebo-controlled, randomized clinical trial 56 children with active despite immunosuppressive treatment, conducted August 2008-September 2012 6 tertiary care centers...
Pre-therapeutic DPYD pharmacogenetic test to prevent fluoropyrimidines (FL)-related toxicities is not yet common practice in medical oncology. We aimed at investigating the clinical validity of genetic analysis a large series oncological patients. Six hundred three cancer patients, treated with FL, have been retrospectively tested for eight polymorphisms (DPYD-rs3918290, DPYD-rs55886062, DPYD-rs67376798, DPYD-rs2297595, DPYD-rs1801160, DPYD-rs1801158, DPYD-rs1801159, DPYD-rs17376848)...
Background Dysregulated systemic inflammation is the primary driver of mortality in severe coronavirus disease 2019 (COVID-19) pneumonia. Current guidelines favour a 7–10-day course any glucocorticoid equivalent to dexamethasone 6 mg daily. A comparative randomised controlled trial (RCT) with higher dose and longer duration intervention was lacking. Methods We conducted multicentre, open-label RCT investigate methylprednisolone 80 as continuous daily infusion for 8 days followed by slow...
The impact of body mass index (BMI) on treatment outcomes in patients with cancer is gaining increasing attention given the limited data available. aim this study was to investigate contribution BMI safety and efficacy profile palbociclib 134 metastatic luminal-like breast treated endocrine therapy (ET). Normal-weight underweight (BMI<25) were compared overweight obese (BMI≥25). Detailed clinical demographic collected. Patients a BMI<25 had higher incidence relevant-hematologic toxicities (p...
Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%–38% patients and majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency. Azathioprine is known induce glutathione depletion consumption greater cells with high glutathione-S-transferase (GST) activity compared those low activity; moreover, some reports indicate that GST might play a direct role reaction azathioprine. The association between polymorphisms GST-M1, GST-P1, GST-T1, TPMT...
Background Although dyslexia is one of the most common neurobehavioral disorders affecting children, prevalence uncertain and available data are scanty dated. The objective this study to evaluate in an unselected school population using clearly defined rigorous diagnostic criteria methods. Methods Cross sectional study. We selected a random cluster sample 94 fourth grade elementary classes Friuli Venezia Giulia, Region North Eastern Italy. carried out three consecutive levels screening:...
Background Developmental dyslexia is one of the most common neurobehavioral disorders affecting children, but prevalence data on this condition are poor. The objective present study to determine in Italy an unselected school population, using clearly defined diagnostic criteria and methods. Methods Cross-sectional carried out nine Italian Regions: two located Northern (Friuli Venezia Giulia Veneto), three Central (Marche, Lazio Umbria) four Southern (Abruzzo, Molise, Puglia Sardegna). Three...
Poly (ADP-ribose) polymerase inhibitors (PARPis) are becoming increasingly meaningful in oncology, and their therapeutic drug monitoring (TDM) might be beneficial for patients. Several bioanalytical methods have been reported PARPis quantification human plasma, but advantages obtained using dried blood spot (DBS) as a sampling technique. Our aim was to develop validate liquid chromatography-tandem mass spectrometric (LC-MS/MS) method olaparib, rucaparib, niraparib both plasma DBS matrices....
BACKGROUNDThe influence of thrombophilia on fertility and IVF outcome is very controversial. The objectives this study were: (i) to compare the prevalence Factor V Leiden (FVL) prothrombin gene G20210A mutation (PGM) in women undergoing with spontaneous pregnancy; (ii) outcomes risk complications FVL PGM carrier non-carrier women.
<h3>Objectives</h3> To assess the effectiveness of sublingual ketorolac versus tramadol in reducing pain associated with fracture or dislocation extremities children. <h3>Patients and methods</h3> A double-blind, randomised, controlled, non-inferiority trial was conducted paediatric emergency department a research institute. One hundred thirty-one children aged 4–17 years suspected bone were enrolled. Eligible randomised to (0.5 mg/kg) placebo, (2 placebo by administration, using...
Abstract Aim The aim of this study was to quantify the prevalence somatic pain in a paediatric emergency department ( ED ). Methods We conducted prospective observational using patients admitted an Italian children's hospital between December 2014 and February 2015. enrolled children aged 7–17 who turned up at complaining pain. Patients parents were asked fill questionnaire allow analysis patients’ medical history provide contact details for follow‐up. divided into four groups:...