A5033468586- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Advanced Photocatalysis Techniques
- RNA Interference and Gene Delivery
- MXene and MAX Phase Materials
- Advanced Nanomaterials in Catalysis
- Flavonoids in Medical Research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Natural product bioactivities and synthesis
- Regional resilience and development
- Luminescence Properties of Advanced Materials
- Pharmacological Effects of Natural Compounds
- Food Quality and Safety Studies
- Electrocatalysts for Energy Conversion
- Fuel Cells and Related Materials
- Misinformation and Its Impacts
- Smart Cities and Technologies
- Mosquito-borne diseases and control
- Cancer, Stress, Anesthesia, and Immune Response
- Ga2O3 and related materials
Shenzhen University
2024
University of Science and Technology Beijing
2017-2023
Shandong Jianzhu University
2023
Beijing University of Chinese Medicine
2019-2021
Beijing Jiaotong University
2019
The integration of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhanced anticancer effects. Herein, we report biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the lines ROS generation through singlet (1O2) production glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic We demonstrate that mCMSNs...
Abstract The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H 2 O ) chemodynamic (CDT). Here, we report a H /O self-supplying nanoagent, (MSNs@CaO -ICG)@LA, which consists manganese silicate (MSN)-supported calcium (CaO indocyanine green (ICG) with further surface modification phase-change material lauric acid (LA). Under laser...
Abstract The two‐dimensional (2D) vanadium carbide (V 2 C) MXene has shown great potential as a photothermal agent (PTA) for therapy (PTT). However, the use of V C in PTT is limited by harsh synthesis condition and low conversion efficiency (PTCE). Herein, we report completely different green delamination method using algae extraction to intercalate delaminate AlC produce mass nanosheets (NSs) with high yield (90 %). resulting NSs demonstrated good structural integrity remarkably absorption...
Abstract Herein, a cancer cell (MCF‐7 cell) membrane‐encapsulated dendritic mesoporous silica nanoparticle simultaneously functionalized with DNA‐photoacoustic (DNA‐PA) probes and glutathione (GSH)‐responsive DNA fuel strands for PA imaging of tumor‐related miRNA in living mice signal amplification ability is developed. It demonstrated that one target can trigger disassembly multiple fluorophore from the quencher aid GSH‐responsive via entropy‐driven process, resulting remarkable amplified...
Developing nanophotothermal agents (PTAs) with satisfied photothermal conversion efficiency (PTCE) in the second NIR window (1000–1350 nm, II) holds great promise for enhanced therapy effect. Herein, we develop a NIR-II PTA advanced PTCE, based on new two-dimensional ultrathin tellurium oxide/ammonium tungsten bronze (TeO2/(NH4)xWO3) nanoribbons (TONW NRs). The doped ammonia ions-mediated-free-electrons injection into lowest unoccupied molecular orbital band of WO3 combined electronic...
Abstract Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO 2 (H‐MnO ) are demonstrated for achieving not only nucleus‐targeted NIR‐II photothermal therapy (PTT), but also tumor microenvironment (TME) hypoxia relief enhanced photodynamic (PDT). The present a conversion efficiency (PTCE) as high 56.9%, superior those PTAs activated in the...
There is intense interest in visualizing intracellular microRNA (miRNA) situ due to its valuable diagnostic and prognostic function expressional heterogeneity. The direct monitoring of miRNA level with a wide concentration range ultralow amount remains key challenge. Herein, we report responsive DNA "nano wheel" (DNW) by hybridization modified six hairpin structures programmed nanowire for highly efficient fast imaging living cells. We demonstrate that one target able trigger the nearby...
Abstract Here, in terms of the highly reactive oxidative hydroxyl radical (•OH) generation ability isoniazid (INH) catalyzed by Mn 2+ ion and photothermal effect WSSe nanoflakes, a WSSe/MnO 2 ‐INH nanocomposite for synergistic anticancer treatment is developed. Advanced INH‐induced •OH formation systemically demonstrated presence manganese relevant non‐Fenton‐type mechanism, good conversion efficiency nanocomposite. After modifying with mitochondria‐targeted triphenylphosphonium bromide...
Quantifying intracellular microRNA (miRNA) is essential for diagnosis and prognosis of diseases because its importance to the development progression complex diseases. The challenge develop methods that enable multiplex miRNAs detection in ultralow amounts over broad concentration ranges. Inspired by "tentacles" an octopus, herein, we present a framework nucleic acid (FNA) capture sensitive, rapid, multiplexed imaging cancer biomarkers living cells. programmable FNA designed using three DNA...
Abstract Simultaneous imaging of multiple microRNAs (miRNAs) in individual living cells is challenging due to the lack spectrally distinct encoded fluorophores and non‐cytotoxic methods. We describe a multiplexed error‐robust combinatorial fluorescent label‐encoding method, termed error‐corrected labels (FluoELs), enabling miRNA with error‐correcting capability. The FluoELs comprise proportional dual for encoding constant quantitative single fluorophore quantification. Both are embedded 260...
A novel cascade assembly reaction is applied to sensitively distinguish between low abundance miRNAs and pre-miRNAs in living cells.
Antibiotic-resistant bacterial strains have been continuously increasing and becoming a supreme threat to public health globally. The nanoparticle-based photothermal treatment has emerged as powerful tool combat toxic bacteria. Photothermal agents (PTAs) with cost-effective high conversion efficiency are highly desirable. Herein, we unite the green process for delamination of V2AlC produce yield mass two-dimensional (2D) V2C nanosheets (NSs) by using algae extracts demonstrate their...
Abstract The aberrant expression level of intracellular microRNAs (miRNAs) holds great promise for differentiating cell types at the molecular level. However, subtype discrimination based on a single miRNA is not sufficient and reliable. Herein, multiple identifiable reporting modules are integrated into DNA circuit cancer subtypes identification miRNAs bispecific recognition. three‐dimensional (3D) logic gate nano‐hexahedron framework extends three recognition to form “AND” gates. Each...
Biodegradable FeWO<sub>x</sub>-PEG-RGD nanoparticles for (<italic>T</italic><sub>2</sub>/<italic>T</italic><sub>1</sub>-weighted) MR/CT dual-modal imaging-guided PTT/PDT/CDT synergistic therapy.
Abstract Optically active nanostructures consisting of organic compounds and metallic support have shown great promise in phototherapy due to their increased light absorption capacity high energy conversion. Herein, we conjugated chlorophyll (Chl) vanadium carbide (V 2 C) nanosheets for combined photodynamic/photothermal therapy (PDT/PTT), which reserves the advantages each modality while minimizing side effects achieve an improved therapeutic effect. In this system, Chl from Leptolyngbya...
A dual function system that inhibits tumor growth while promoting wound healing is very necessary for melanoma treatment since killing and skin are two complementary influential processes. Herein, a controllable local drug delivery based on porous fiber membranes incorporated with CuS nanoparticles designed chemo-photothermal synergistic therapy healing. The structure the surface significantly increases loading capacity of membrane photothermal effect used to control release rate....
Human malaria is a global life-threatening infectious disease. Cerebral (CM) induced by Plasmodium falciparum parasites accounts for 90% of deaths. Treating CM challenging due to inadequate treatment options and the development drug resistance. We describe nanoparticle formulation antimalarial dihydroartemisinin that coated in biomimetic membrane derived from brain microvascular endothelial cells (BMECs) test its therapeutic efficacy mouse model experimental cerebral (ECM). The...
Abstract The two‐dimensional (2D) vanadium carbide (V 2 C) MXene has shown great potential as a photothermal agent (PTA) for therapy (PTT). However, the use of V C in PTT is limited by harsh synthesis condition and low conversion efficiency (PTCE). Herein, we report completely different green delamination method using algae extraction to intercalate delaminate AlC produce mass nanosheets (NSs) with high yield (90 %). resulting NSs demonstrated good structural integrity remarkably absorption...
For the effects of multi-component environment on solubility and permeability single components,and problems biopharmaceutical attribute classification components in compound prescriptions environment,baicalein was used as research object this study to investigate biopharmaceutic attributes single-component their traditional Chinese medicine( TCM) Gegen Qilian Decoction. Shaking flask method,intrinsic dissolution rate test HPLC were determine baicalein. Markers specified by FDA utilized...