A5021619043- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Viral Infections and Immunology Research
- Biotin and Related Studies
- Aquaculture disease management and microbiota
- Infant Nutrition and Health
- Gut microbiota and health
- Rabies epidemiology and control
- Antimicrobial Peptides and Activities
- Cellular transport and secretion
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Veterinary Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Venomous Animal Envenomation and Studies
- Animal Nutrition and Physiology
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Circular RNAs in diseases
Anhui Science and Technology University
2024
Anhui University of Science and Technology
2024
Huazhong Agricultural University
2019-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2022-2023
State Key Laboratory of Agricultural Microbiology
2022
Porcine epidemic diarrhea virus (PEDV), a member of the α-coronavirus genus, can cause vomiting, diarrhea, and dehydration in piglets. Neonatal piglets infected with PEDV have mortality rate as high 100%. has caused substantial economic losses to pork industry. Endoplasmic reticulum (ER) stress, which alleviate accumulation unfolded or misfolded proteins ER, involves coronavirus infection. Previous studies indicated that ER stress could inhibit replication human coronaviruses, some...
Background: Rotavirus (RV) is a major cause of diarrhea in young children and animals, especially piglets, leading to substantial economic losses the global pig industry. Isoleucine (Ile), branched-chain amino acid, plays an important role regulating nutrient metabolism has been shown improve diarrhea. This study aimed evaluate effects Ile supplementation on mucosal immune barrier small intestine RV-infected weaned piglets. Methods: Forty-eight 21-day-old piglets were randomly divided into...
Porcine epidemic diarrhea virus (PEDV) could cause lethal and dehydration in suckling piglets, which can adversely affect the development of global swine industry. The lack effective therapeutical prophylactic treatment especially for PEDV variant strains underlines importance antiviral strategies, such as identification novel agents. In present study, activity cinchonine against was investigated Vero CCL81 LLC-PK1 cells at a non-cytotoxic concentration determined by Cell Counting Kit-8...
G. parasuis can cause serious Glasser’s disease, which is characterized by polyarthritis, meningitis, and fibrinous polyserositis in pigs. It high morbidity mortality swine herds major economic losses to the global pig industry.
Porcine circovirus type 2 (PCV2) is closely linked to postweaning multisystemic wasting syndrome (PMWS) and other PCV-associated diseases (PCVADs), which influence the global pig industry. MicroRNAs (miRNAs) are evolutionarily conserved classes of endogenous small non-coding RNA that regulate almost every cellular process. According our previous transcription study, PCV2 infection causes up-regulation genes related inflammation. To reveal function miRNAs in PCV2-encoded miRNAs, next...
Haemophilus parasuis (HPS), a member of the family Pasteurellaceae, is common bacteria in upper respiratory tract pigs but under certain circumstances can cause serious systemic disease (Glasser's disease) characterized by severe infection tract, fibrinous polyserositis, polyarthritis, and meningitis. cAMP receptor protein (CRP) among most important global regulators, playing vital role adapting to environmental changes during process bacterial infection. In order investigate function crp...
Porcine epidemic diarrhea virus (PEDV) variant strains adversely affect the production of pigs globally. Vaccines derived from PEDV traditional impart less protection against strains. Moreover, sequence diversity among different is also complicated. This necessitates developing alternative antiviral strategies for defending PEDV. study explored a natural product, Levistolide A (LA), to possess activity LA was found suppress replication in dose-dependent manner. And inhibitory effect...
Porcine deltacoronavirus (PDCoV) is an emerging pathogen that can cause severe diarrhoea and high mortality in suckling piglets. Moreover, evidence of PDCoV infection humans has raised concerns regarding potential public health risks. To identify therapeutic targets for PDCoV, we performed a genome-wide CRISPR/Cas9 library screening to find key host factors important infection. Several genes this screen were enriched, including ANPEP, which encodes the receptor aminopeptidase N (APN)....
Rotavirus (RV) is a significant contributor to diarrhea in both young children and animals, especially piglets, resulting considerable economic impacts on the global pig industry. Isoleucine (Ile), branched-chain amino acid, crucial for regulating nutrient metabolism has been found help mitigate diarrhea. This study aimed assess impact of isoleucine supplementation feed colonic barrier function, microbiota, RV-infected weanling piglets. A total thirty-two weaned aged 21 days, were randomly...
Actinobacillus pleuropneumoniae (APP) is a gram-negative pathogenic bacterium responsible for porcine contagious pleuropneumonia (PCP), which can cause necrotizing and hemorrhagic pleuropneumonia. pleuropneumoniae-RTX-toxin (Apx) an APP virulence factor. secretes total of four Apx toxins, among which, ApxI demonstrates strong hemolytic activity cytotoxicity, causing lysis erythrocytes apoptosis alveolar macrophages. However, the protein interaction network between this toxin host cells still...
Background Antimicrobial peptides (AMPs) have been identified as promising compounds for consideration novel antimicrobial agents. Objectives This study analyzed the efficacy of cecropin B against Haemophilus parasuis isolates through scanning electron microscopy (SEM) and atomic force (AFM) experiments. Results Cecropin exhibited broad inhibition activity 15 standard (HPS) strains 5 clinical had minimum concentrations (MICs) ranging from 2 to 16 μg/mL. Microelectrophoresis hexadecane...
The ability of bacteria to resist heat shock allows them adapt different environments. In addition, resistance is known for their virulence. Our previous study showed that the AI-2/luxS quorum sensing system affects growth characteristics, biofilm formation, and virulence Glaesserella parasuis . deficient G. was obviously weaker than wild type strain. However, regulatory mechanism this phenotype remains unclear. To illustrate by which provides shock, transcriptomes (GPS2), ΔluxS, luxS...