A5091428969- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Radiation Therapy and Dosimetry
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Multiple and Secondary Primary Cancers
Radboud University Medical Center
2012-2023
Itasca Consultants (France)
2023
Radboud University Nijmegen
2012-2023
Ziekenhuis Gelderse Vallei
2016-2023
Deventer Ziekenhuis
2010
In the past 15 years, encouraging clinical results for detection of small lymph node metastases was obtained by use Combidex-enhanced MRI (CEM, also known as magnetic resonance lymphography). Withdrawal European Medicines Agency approval application manufacturer made it impossible patients to benefit from this agent; a loss, especially men with prostate cancer. Current conventional imaging techniques are not accurate CEM is, thus surgical diagnostic exploration (extended dissection) is still...
To evaluate the technical feasibility of high-resolution USPIO-enhanced magnetic resonance imaging pelvic lymph nodes (LNs) at ultrahigh field strength. The ethics review board approved this study and written informed consent was obtained from all patients. Three patients with rectal cancer three selected (recurrent) prostate were examined 7-T 24–36 h after intravenous ferumoxtran-10 administration; also received a 3-T MRI. Pelvic LN performed using TIAMO technique in combination...
Purpose Pelvic lymph node (PLN) metastases are often smaller than 5 mm and difficult to detect. This work presents a method perform PLN imaging with ultrahigh‐field MRI, using spectrally selective excitation acquire water lipid‐selective at high spatial resolution. Methods A 3D water‐selective multigradient echo (mGRE) sequence gradient (GRE) were tested in six healthy volunteers on 7 Tesla (T) MRI system, time interleaved acquisition of modes (TIAMO) improve image homogeneity. The size...
The key to MR lymphography is suppression of T2* signal in normal lymph nodes, while retaining high metastatic nodes. Our objective quantitatively compare the ability ferumoxtran-10 and ferumoxytol suppress pelvic nodes.In 2010, a set consecutive patients who underwent intravenous Lymphography (MRL) were included. Signal nodes T2*-weighted images due uptake USPIO (Ultra-Small Superparamagnetic Particles Iron Oxide) was quantified. by two contrast agents, compared using Wilcoxon's signed rank...
The definition of an in vivo nodal anatomical baseline is crucial for validation representative lymph node dissections and accompanying pathology reports pelvic cancers, as well assessing a potential therapeutic effect extended dissections. Therefore the number, size distribution nodes pelvis were assessed with high-resolution, large field-of-view, 7 Tesla (T) magnetic resonance imaging (MRI) frequency-selective excitation.We used T MRI homogeneous 11 young healthy volunteers....
Background Accurate detection of lymph node (LN) metastases in prostate cancer (PCa) is a challenging but crucial step for disease staging. Ultrasmall superparamagnetic iron oxide (USPIO)–enhanced magnetic resonance imaging (MRI) enables distinction between healthy LNs and nodes suspicious harboring metastases. When combined with MRI at an ultra-high field, unprecedented spatial resolution can be exploited to visualize these LNs. Purpose The aim this study was explore USPIO-enhanced 7 T...