A5013005935- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Bat Biology and Ecology Studies
- Zoonotic diseases and public health
Institut Pasteur du Cambodge
2024
Makerere University
2018-2024
Zoonotic viruses cause substantial public health and socioeconomic problems worldwide. Understanding how evolve spread within among wildlife species is a critical step when aiming for proactive identification of viral threats to prevent future pandemics. Despite the many proposed factors influencing diversity, genomic diversity structure communities in East Africa are largely unknown.
Introduction: A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role bats in arbovirus maintenance is poorly understood. The aim this study was to investigate exposure history Ugandan a panel arboviruses. Materials and methods: Insectivorous fruit were captured multiple locations throughout Uganda during 2009 2011-2013. All serum samples tested for neutralizing antibodies against West Nile virus (WNV), yellow fever (YFV), dengue 2...
While serological and virological evidence documents the exposure of bats to medically-important arboviruses, their role as reservoirs or amplifying hosts is less well-characterized. We describe a novel orbivirus (
Abstract Serological cross-reactivity among flaviviruses makes determining the prior arbovirus exposure of animals challenging in areas where multiple flavivirus strains are circulating. We hypothesized that infection with ZIKV could be confirmed through presence subgenomic RNA (sfRNA) 3′ untranslated region (UTR), which persists tissues due to XRN-1 stalling during decay. amplified sfRNA but not NS5 from three experimentally-infected Jamaican fruit bats, supporting hypothesis tissue...
The reservoir for zoonotic o'nyong-nyong virus (ONNV) has remained unknown since this was first recognized in Uganda 1959. Building on existing evidence mosquito blood-feeding various frugivorous bat species Uganda, and seroprevalence arboviruses among bats we sought to assess if serum samples collected from demonstrated of exposure ONNV or the closely related chikungunya (CHIKV). In total, 652 six were tested by plaque reduction neutralization test (PRNT) neutralizing antibodies against...