A5009592517- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammatory Bowel Disease
- Pharmacological Effects and Toxicity Studies
- Radiomics and Machine Learning in Medical Imaging
- Diverticular Disease and Complications
- Whipple's Disease and Interleukins
- Leprosy Research and Treatment
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- HIV/AIDS Research and Interventions
- Gastric Cancer Management and Outcomes
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Autoimmune and Inflammatory Disorders
University College London
2024
Mayo Clinic in Arizona
2024
Cleveland Clinic
2024
Cleveland Clinic Lerner College of Medicine
2024
University of Calgary
2024
University of Ljubljana
2024
Ljubljana University Medical Centre
2024
United States Army Medical Research Directorate - Africa
2016-2019
Kenya Medical Research Institute
2016-2019
Maseno University
2016
Background Standardized methods to measure and describe Crohn disease strictures at CT enterography are needed guide clinical decision making for use in therapeutic studies. Purpose To assess the reliability of features their correlation with stricture severity. Materials Methods A retrospective study was conducted 43 adult patients symptomatic terminal ileal who underwent standard-of-care a tertiary care center Cleveland Clinic between January 2008 August 2016. After training on...
Abstract Background and Aims Non-invasive cross-sectional imaging via magnetic resonance enterography [MRE] offers excellent accuracy for the diagnosis of stricturing complications in Crohn’s disease [CD] but is limited determining degrees fibrosis inflammation within a stricture. We developed validated radiomics-based machine-learning model separately characterizing degree histopathological CD strictures compared it to centrally read visual radiologist scoring MRE. Methods This...
Objective Cotrimoxazole prevents opportunistic infections including falciparum malaria in HIV-infected individuals but there are concerns of cross-resistance to other antifolate drugs such as sulphadoxine-pyrimethamine (SP). In this study, we investigated the prevalence antifolate-resistance mutations Plasmodium that associated with SP resistance on antiretroviral treatment randomized discontinue (STOP-CTX), or continue (CTX) cotrimoxazole Western Kenya. Design Samples were obtained from an...
Cotrimoxazole (CTX) discontinuation increases malaria incidence in human immunodeficiency virus (HIV)-infected individuals. Rates, quantity, and timing of parasitemia rebound following CTX remain undefined. Serial specimens from a trial HIV-infected individuals receiving antiretroviral treatment (ART) randomized to continue (the arm) or discontinue STOP-CTX were examined for parasites by quantitative reverse transcription polymerase chain reaction (PCR). Specimens obtained at enrollment then...