A5090924072- Mass Spectrometry Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Health Systems, Economic Evaluations, Quality of Life
- Metabolomics and Mass Spectrometry Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- High Altitude and Hypoxia
- Advanced Proteomics Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Botulinum Toxin and Related Neurological Disorders
- DNA Repair Mechanisms
- Pharmaceutical industry and healthcare
- Injury Epidemiology and Prevention
- Healthcare Policy and Management
- Occupational Health and Safety Research
- Respiratory Support and Mechanisms
- Doping in Sports
- Ion-surface interactions and analysis
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Pharmaceutical Practices and Patient Outcomes
- Climate Change and Health Impacts
Pfizer (United States)
2011-2025
Impact Assessment
2024
Liverpool Hospital
2018
Australian National University
2016
University of Aberdeen
1985-2013
Genomics (United Kingdom)
2009
University of Oxford
2009
University of Wollongong
2004-2008
University of South Carolina
2006
Aberdeen Royal Infirmary
1994-2005
The link between long-haul air travel and venous thromboembolism is the subject of continuing debate. It remains unclear whether reduced cabin pressure oxygen tension in airplane create an increased risk compared with seated immobility at ground level.To determine hypobaric hypoxia, which may be encountered during travel, activates hemostasis.A single-blind, crossover study, performed a chamber, to assess effect 8-hour exposure hypoxia on hemostasis 73 healthy volunteers, was conducted...
Ubiquitination has emerged as one of the major post-translational modifications that decide on protein fate, targeting, and regulation function. Whereas ubiquitination proteins can be monitored with classic biochemical methods, mapping modified side chains proves to challenging. More recently, mass spectrometry been applied identify ubiquitinated also their sites modification. Typically, liquid chromatography tandem (LC-MS/MS) based approaches, including collision-induced fragmentation...
Many decision-makers have emphasized the importance of leveraging patient experience data to measure unmet need. However, there is no standardized, patient-centric need that formalizes how value judgements inherent in such a should be made. Several initiatives identified measuring as one primary uses preference data. After reviewing define need, this paper proposes thresholding method could used generate patient-centric, disease-agnostic, quantitative estimate, length life equivalent (LOLE)....
An Escherichia coli cell‐free transcription/translation system was used to explore the high‐level incorporation of l ‐3,4‐dihydroxyphenylalanine (DOPA) into proteins by replacing tyrosine with DOPA in reaction mixtures. ESI‐MS showed specific place tyrosine. More than 90% at each site achieved, allowing recording clean 15 N‐HSQC NMR spectra. A redox‐staining method for shown provide a sensitive and generally applicable assessing production proteins. Of four produced soluble form presence...
A platinum metal complex in which terpyridine joins estradiol (via an ethynyl link) to a with labile ligand (chloride) has been designed, synthesised and its X-ray crystal structure determined. The aim of this work was link targeting motif (in case estrogen) metal-based biomolecule recognition unit (the moiety). target molecule: 17alpha-[4'-ethynyl-2,2':6',2'-terpyridine]-17beta-estradiol platinum(II) chloride (PtEEtpy) shown bind both human bovine serum albumin (SA) DNA. FTICR mass...
To evaluate the impact of pregabalin on sleep, pain, function, and health status in patients with chronic low back pain accompanying neuropathic (CLBP-NeP) under routine clinical practice.This prospective, non-interventional, observational study enrolled Japanese adults (≥18 years) CLBP-NeP duration ≥3 months severity ≥5 a numerical rating scale (0= no 10= worst possible pain). Treatment was 8 weeks (n=157) or usual care alone (n=174); choice treatment determined by physician. The primary...
PURPOSE Cancer drug development remains a critical but challenging process that affects millions of patients and their families. Using biomedical informatics artificial intelligence (AI) approaches, we assessed the regulatory translational research landscape defining successful first-in-class drugs for with cancer. METHODS This is retrospective observational study all novel approved by US Food Drug Administration (FDA) from 2018 to 2022, stratified cancer versus noncancer drugs. A pipeline...
A retrospective analysis of spirometric data from divers attending for annual medical examination at intervals three to nine years was carried out examine the long term effect diving on lung volumes. Those with records over a or four year interval (group 1, n = 224) showed mean reduction forced vital capacity (FVC) 240 ml; those five more 2, 123) FVC 400 ml. These reductions remained significant when expressed as percentage predicted normal values. The between did not correlate diver's age,...
To compare the health status of UK professional divers and age-matched non-divers to contrast offshore (OSDs) with non-offshore (NOSDs).A postal survey sent 2958 male divers, registered Health & Safety Executive (HSE) before 1991, 2708 men who had worked in oil industry 1990-92 (non-divers). The questionnaire addressed lifestyle, occupation status.In all, 56% 51% responded. Three per cent participants reported ill-health retirement or being off-work on sickness benefit no difference between...
BACKGROUND--The efficacy of an antibiotic is related to its concentration at the site infection. Previous studies concentrations amoxycillin and clavulanic acid (co-amoxiclav) in respiratory secretions or whole lung tissue have suffered from methodological problems. The was determined bronchial mucosal biopsy samples obtained bronchoscopy following five different dosing regimens. METHODS--Bronchial serum were 50 patients undergoing diagnostic bronchoscopy. Ten each received 375 mg, 625 750...
Changes in protein conformation are thought to alter charge state distributions observed electrospray ionization mass spectra (ESI-MS) of proteins. In most cases, this has been demonstrated by unfolding proteins through acidification the solution. This methodology changes properties solvent so that ESI-MS envelopes from conformational difficult separate effects changing on process. A novel strategy is presented enabling comparison ESI a folded and partially unfolded same amino acid sequence...
This study attempted to determine whether the higher prevalence of reported "forgetfulness or loss concentration" among professional divers can be confirmed using objective neuropsychological tests. Secondary aims were qualify functional nature complaints and ascertain reduced performance was linked diving history.In a case-control study, test complaining moderate severe compared with two age-matched control groups reporting no slight ("nonforgetful" "nonforgetful" nondivers). The group...