A5016224436- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Nutritional Studies and Diet
- Frailty in Older Adults
- COVID-19 and Mental Health
- Health, psychology, and well-being
- Geriatric Care and Nursing Homes
- Maternal Mental Health During Pregnancy and Postpartum
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Delphi Technique in Research
- Mental Health and Patient Involvement
- Optimism, Hope, and Well-being
- Family Caregiving in Mental Illness
- Anesthesia and Neurotoxicity Research
- Physical Activity and Health
- Diet and metabolism studies
- Aging and Gerontology Research
- Health Systems, Economic Evaluations, Quality of Life
- Health and Wellbeing Research
- Retirement, Disability, and Employment
- Mental Health Treatment and Access
- Workplace Health and Well-being
Kiel University
2015-2025
University Hospital Schleswig-Holstein
2015-2023
University of Lübeck
2015-2023
Autobiographical memories in our lives are critically dependent on temporal lobe structures. However, the contribution of CA1 neurons human hippocampus to retrieval episodic autobiographical memory remains elusive. In patients with a rare acute transient global amnesia, highly focal lesions confined field can be detected MRI. We studied effect these using detailed interview including remember/know procedure. 14 16 patients, sector hippocampal cornu ammonis were detected. was significantly...
The CA1 (cornu ammonis) region of hippocampus is selectively vulnerable to a variety metabolic and cytotoxic insults, which mirrored in delayed neuronal death neurons. basis mechanisms this regional susceptibility neurons are poorly understood, the correlates human diseases affecting not clear. Adopting translational approach, lesion evolution, temporal course, pattern diffusion changes, damage hippocampal acute neurologic disorders were studied using high-resolution magnetic resonance...
Abstract INTRODUCTION We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia Germany cluster‐randomized trial. METHODS Individuals with Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score ≥ 9 aged 60 77 years were recruited. After randomization their general practitioner (GP), patients received (including optimization nutrition medication, physical, social, activity) or health advice GP treatment as usual...
Abstract Background Aim of this study was to detect predictors better adherence the AgeWell.de-intervention, a two-year randomized multi-domain lifestyle intervention against cognitive decline. Methods Data 317 group-participants comprising risk group for dementia (Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) score ≥ 9; mean age 68.9 years, 49.5% women) from AgeWell.de were analysed. Regression models with four blocks (sociodemographic, psychosocial, factors chronic conditions)...
Abstract INTRODUCTION The societal costs of dementia and cognitive decline are substantial likely to increase during the next decades due increasing number people in older age groups. aim this multicenter cluster‐randomized controlled trial was assess cost‐effectiveness a multi‐domain intervention prevent who at risk for dementia. METHODS We used data from multi‐centric, two‐armed, ( AgeWell.de trial, ID: DRKS00013555). Eligible participants with increased baseline (Cardiovascular Risk...
Background The aim of the study was to analyze impact adherence intervention components on effectiveness AgeWell.de, a multi-domain lifestyle against cognitive decline, function in everyday activities, quality life, depressiveness and social isolation. Objective Studying effect health-related outcomes. Methods Participants were aged 60–77 years at baseline risk (Cardiovascular Risk Factors, Ageing Dementia Score (CAIDE) ≥9). Adherence nutrition, enhancement physical activities training...
Targeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the large-scale initiative investigating effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate recruitment process and baseline characteristics participants gain an understanding population who engages intervention. General practitioners across five study sites recruited (aged...
Differences between women and men matter in the prevalence risk factors of dementia. We aimed to examine potential sex differences regarding effectiveness by running a secondary analysis AgeWell.de trial, cluster-randomized multicenter multi-domain lifestyle intervention reduce cognitive decline. Intention-to-treat analyses (n=433) (n=386) aged 60 77 years were used for models including interactions group allocation followed subgroup stratified on primary outcomes. Further, same procedure...
Spatial navigation critically underlies hippocampal-entorhinal circuit function that is early affected in Alzheimer's disease (AD). There growing evidence AD pathophysiology dynamically interacts with the sleep/wake cycle impairing hippocampal memory. To elucidate sleep-dependent consolidation a cohort of symptomatic patients (n = 12, 71.25 ± 2.16 years), we tested place learning by means virtual reality task and verbal memory word-pair association before after night sleep. Our results show...
Our study aims to examine the associations of sociodemographic factors, social support, resilience, and perceptions COVID-19 pandemic with late-life depression anxiety symptoms in a cardiovascular risk group matched sample from German general population during beginning draw comparison regarding psychosocial characteristics. Data n = 1236 participants (aged 64-81 years) were analyzed, 618 showing profile, population. The had slightly higher levels depressive felt more threatened by virus due...
With the outbreak of COVID-19, government measures including social distancing and restrictions contacts were imposed to slow spread virus. Since older adults are at increased risk severe disease, they particularly affected by these restrictions. These may negatively affect mental health loneliness isolation, which constitute factors for depressiveness. We aimed analyse impact perceived restriction due on depressive symptoms investigated stress as mediator in an at-risk-population Germany....
To develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) the earliest form The aim this study assess depression as a factor that significantly with SCD. data 1030 general practitioner patients from AgeWell.de-study (60-77 years; CAIDE score ≥ 9) were analysed. A descriptive analysis was conducted using validated instruments like Geriatric scale (GDS), Lubben social...
Background: Studies demonstrate associations between low social activity in older adults and cognitive decline. Little has been investigated regarding which factors are associated with at increased risk of dementia. Objective: We investigate sociodemographic, psychological, health-related, environmental Additionally, we describe the stages health behavior change, types activities, duration current level activity. Methods: used baseline data 1,015 participants from AgeWell.de trial. conducted...
While regular physical-activity (PA) is beneficial, multimorbid individuals at increased dementia risk may exhibit reduced PA levels. Thus, a more comprehensive understanding of mediating factors responsible for inactivity in this population needed. This study investigated the impact multimodal intervention on changes 24-month follow-up and associated among community-dwelling patients aged 60-77, with determined by CAIDE Dementia Risk Score. Of 1030 participants recruited, 819 completed...
This study aims to describe social network and participation assess associations with depressive symptoms in older persons increased risk for dementia Germany. We conducted a cross-sectional observational primary care patients (aged 60−77) as part of multicenter cluster-randomized controlled trial (AgeWell.de). present descriptive multivariate analyses networks (Lubben Social Network Scale subscales) (item list activities) analyze these variables (Geriatric Depression Scale). Of 1030...
Growing evidence suggests a protective effect of high mental demands at work on cognitive function in later life. However, corresponding associations older adults increased risk for dementia is currently lacking. This study investigates the association between and functioning population AgeWell.de-trial.Cross-sectional investigation global (Montreal Cognitive Assessment) individuals (Cardiovascular Risk Factors, Aging, Incidence Dementia (CAIDE)score ≥ 9; n = 941, age: 60-77 years)....
Quality of Life (QoL) is associated with a bandwidth lifestyle factors that can be subdivided into fixed and potentially modifiable ones. We know too little about the role in comparison to This study examines four aspects QoL its associations 15 sample elderly primary care patients high risk dementia. The main objectives are (a) determine this particular group (b) assess proportion factors.
Abstract Background General practitioners (GPs) play a crucial role in identifying cognitive impairment and dementia providing post-diagnostic care. This study investigates (1) how promising GP consider lifestyle changes to maintain performance general, (2) beliefs about the power of modifiable health factors performance, (3) whether those vary by age. Methods As part AgeWell.de trial, GPs ( n = 72) completed process evaluation questionnaire assessing their perspectives on preserve elderly...
Objectives Various dementia risk scores exist that assess different factors. We investigated the association between Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score modifiable factors in Lifestyle for Brain Health (LIBRA) a German population at high Alzheimer's disease.
We investigated the effects of a multidomain lifestyle intervention conducted in older adults at increased risk for dementia on participants' diet.
Transient global amnesia (TGA) is a rare neurological disorder with sudden, temporary episode of memory loss which usually occurs in old age. The episodic becomes normal after stipulated time approximately 24 hours. precise pathology not yet completely understood. Moreover, there no proper neuroimaging method to assess this condition. In study, the EEG was measured at two points one occurrence (acute) and second point patient returns condition (follow-up). aim study look pathological network...