A5038292093- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and Mental Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Infant Development and Preterm Care
- Child and Adolescent Psychosocial and Emotional Development
- Pediatric Hepatobiliary Diseases and Treatments
- Respiratory viral infections research
- Child and Adolescent Health
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Economic and Financial Impacts of Cancer
- Lung Cancer Treatments and Mutations
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Psychological and Temporal Perspectives Research
- Uterine Myomas and Treatments
- Maternal and fetal healthcare
- Colorectal Cancer Treatments and Studies
- SARS-CoV-2 detection and testing
- Selenium in Biological Systems
Universitätsmedizin Greifswald
2021-2025
Institute for Community Health
2022-2024
Charité - Universitätsmedizin Berlin
2018-2022
Humboldt-Universität zu Berlin
2019-2022
Freie Universität Berlin
2019-2022
Weatherford College
2021
The national Network Genomic Medicine (nNGM) Lung Cancer provides comprehensive and high-quality multiplex molecular diagnostics standardized personalized treatment recommendation for patients with advanced non-small cell lung cancer (aNSCLC) in Germany. primary aim of this study was to investigate the effectiveness nNGM precision medicine program terms overall survival (OS) using real-world data (RWD).A historical nationwide cohort analysis aNSCLC initial diagnosis between 04/2019 06/2020...
Abstract Introduction: The objective of this study is to compare the 5 year overall survival patients with stage I–III colon cancer treated by laparoscopic colectomy versus open colectomy. Methods: Using Mecklenburg-Western Pomerania Cancer Registry data from 2008 2018, we will emulate a phase III, multicenter, open-label, two-parallel-arm hypothetical target trial in adult who received or as an elective treatment. An inverse-probability weighted Royston‒Parmar parametric model (RPpsm) be...
Background Over the course of COVID-19 pandemic, previous studies have shown that physical as well mental health children and adolescents significantly deteriorated. Future anxiety caused by pandemic its associations with quality life has not previously been examined in school children. Methods As part a cross-sectional web-based survey at schools Mecklenburg-Western Pomerania, Germany, two years after outbreak were asked about COVID-19-related future using German epidemic-related Dark Scale...
Background: Despite recent advances in the field of laparoscopic liver surgery, intrahepatic cholangiocarcinoma (iCC) as an entity has been nearly exempted from new approaches because proposed technical difficulties achieving lymphadenectomy (LAD) and beneficial oncologic outcomes. Materials Methods: Clinical courses all consecutive patients (n = 159) undergoing resection for iCC at Department Surgery, Charité—Universitätsmedizin between January 2015 October 2019 were studied. Ultimately,...
Abstract Background While laparoscopic liver surgery has become a standard procedure, experience with robotic is still limited. The aim of this prospective study was to evaluate safety and feasibility compare outcomes conventional laparoscopy. Methods We here report the results single-center, prospective, post-marketing observational (DRKS00017229) investigating surgery. Baseline characteristics, surgical complexity (using IWATE score), postoperative were then compared resections performed...
Minimal-invasive hepatectomy (MIH) has been increasingly performed for benign and malignant liver lesions with most promising short-term results. However, the oncological role of MIH in treatment patients colorectal metastases (CRLM) needs further investigation. Clinicopathological data who underwent resection CRLM between 2012 2017 at Department Surgery, Charité-Universitätsmedizin Berlin, Inselspital Bern were assessed. Postoperative outcomes und long-term survivals following compared...
The trace element selenium (Se) is taken up from the diet and metabolized mainly by hepatocytes. Selenoprotein P (SELENOP) constitutes liver-derived Se transporter. Biosynthesis of extracellular glutathione peroxidase (GPx3) in kidney depends on SELENOP-mediated supply. We hypothesized that peri-operative status may serve as a useful prognostic marker for outcome patients undergoing liver transplantation due to hepatocellular carcinoma. Serum samples cancer were routinely collected before...
Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, transplantation (LT) required. The aim of our study was to compare short- long-term results after LR LT for the curative treatment hepatoblastoma. Materials Methods: Retrospective analysis all patients treated surgically from January 2000 until December 2019 performed. Demographic clinical data were collected before surgery. primary endpoints disease free...
With the outbreak of COVID-19, government measures including social distancing and restrictions contacts were imposed to slow spread virus. Since older adults are at increased risk severe disease, they particularly affected by these restrictions. These may negatively affect mental health loneliness isolation, which constitute factors for depressiveness. We aimed analyse impact perceived restriction due on depressive symptoms investigated stress as mediator in an at-risk-population Germany....
Introduction: With the increased emergence of SARS-CoV-2 variants, impact on schools and preschools remains a matter debate. To ensure that are kept open safely, identification factors influencing extent outbreaks is importance. Aim: monitor dynamics COVID-19 infections in identify outbreaks. Methods: In this prospective observational study we analyzed routine surveillance data Mecklenburg-Western Pomerania, Germany, from calendar week (CW) 32, 2020 to CW19, 2021 regarding infection events...
Background and Aim: In recent years, minimally invasive surgical approaches have gained an increasingly important role in hepatobiliary surgery. The aim of this study was to investigate the safety potential benefits laparoscopic liver resection (LLR) compared with open (OLR) for benign tumors lesions. Patients Methods: Between January 2009 December 2017, 182 patients underwent lesions at our center. After exclusion 15 patients, remaining 167 were divided into LLR group (n = 54) OLR 113)...
Purpose: The impact of acute rejection (AR) after liver transplantation (LT) for hepatocellular carcinoma (HCC) on patient outcome is uncertain. This aim this study to investigate whether AR associated with HCC relapse and overall survival. Patients Methods: undergoing LT between 2001 2015 were retrospectively analyzed regard histopathological proven within the median time until recurrence. Cox's regression analysis was conducted revealing risk factors Results: recurred in 47 252 patients a...
Teaching is amongst the six professions with highest stress levels and lowest job satisfaction, leading to a high turnover rate teacher shortages. During pandemic, teachers school principals were confronted new regulations teaching methods. This study aims examine post-pandemic levels, as well resilience factors proactively cope thoughts of leaving profession among principals. We used cross-sectional online survey. The validated instruments Perceived Stress Scale (PSS-10) Proactive Coping...
Abstract Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft‐to‐recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as biological mesh (BM) for abdominal pLT recipients. Patients <2 years age, who underwent from 2011 to 2014, were analyzed, divided into definite with and without implantation BM. Primary end‐point was occurrence postoperative infection. Secondary end‐points included...
Background Since the onset of COVID-19 pandemic, children have been mentally and physically burdened, particularly due to school closures, with an associated loss learning. Therefore, efficient testing strategies high sensitivity are necessary keep schools open. Apart from individual rapid antigen testing, various methods investigated, such as PCR-based pool-testing nasopharyngeal swabs, gargle, or saliva samples. To date, previous validation studies found swab pool method be effective...
Zusammenfassung Hintergrund Trotz überzeugender Ergebnisse international führender Leberzentren ist die laparoskopische Leberchirurgie in Deutschland weiterhin vergleichsweise wenig verbreitet. An der Chirurgischen Klinik Charité – Universitätsmedizin Berlin wurde 2015 ein strukturiertes Programm zur Entwicklung laparoskopischen etabliert, woraus sich mögliche Implikationen für breite Etablierung an deutschen Kliniken ergeben. Methode Wir berichten hier über unsere Zentrumserfahrungen aus...
Abstract Epidemiological data reveal that there is a need for prevention measures specifically targeted at children with low SES. In the German federal state Mecklenburg-Western Pomerania preschools in socially deprived regions can apply additional funds to support developmental risks. Mandatory criteria obtaining these involve an annual assessment of all using “Dortmunder Developmental Screening Preschools (DESK 3–6 R).” This instrument detect and monitor risks domains fine motor skills,...
<title>Abstract</title> Introduction: The objective of this study is to compare the 5-year overall survival patients with stage I – III colon cancer surgically treated by laparoscopic colectomy versus open colectomy. Methods: Using Mecklenburg-Western Pomerania Cancer Registry data from 2008 2018, we will emulate a phase III, multicenter, open-label, two-parallel-arm hypothetical target trial in adult who received or as an elective treatment. An inverse probability-weighted parametric...