A5054396621- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Health and Medical Studies
- Nutritional Studies and Diet
- Workplace Health and Well-being
- Noise Effects and Management
- Health, psychology, and well-being
- Employment and Welfare Studies
- COVID-19 and Mental Health
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Vehicle Noise and Vibration Control
- Psychiatric care and mental health services
- Aging and Gerontology Research
- Sex and Gender in Healthcare
- Health Literacy and Information Accessibility
- Retirement, Disability, and Employment
- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
- Health and Wellbeing Research
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Treatment and Access
- Long-Term Effects of COVID-19
- Spatial Neglect and Hemispheric Dysfunction
- Sexual function and dysfunction studies
Leipzig University
2017-2025
Institut für Soziale Arbeit
2021
Abstract INTRODUCTION We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia Germany cluster‐randomized trial. METHODS Individuals with Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score ≥ 9 aged 60 77 years were recruited. After randomization their general practitioner (GP), patients received (including optimization nutrition medication, physical, social, activity) or health advice GP treatment as usual...
In the absence of treatment options, WHO emphasizes identification effective prevention strategies as a key element to counteract dementia epidemic. Regarding complex nature dementia, trials simultaneously targeting multiple risk factors should be particularly for prevention. So far, however, only few such multi-component have been launched, but yielding promising results. Germany, comparable initiatives are lacking, and translation these interventions into routine care was not yet done....
Abstract INTRODUCTION Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle BRAin health (LIBRA) index, was reduced by AgeWell.de intervention. METHODS Secondary analyses of AgeWell trial, testing a multicomponent intervention (including optimization nutrition, medication, and physical, social, activity) in older adults with increased risk. analyzed data from n...
Abstract Background Aim of this study was to detect predictors better adherence the AgeWell.de-intervention, a two-year randomized multi-domain lifestyle intervention against cognitive decline. Methods Data 317 group-participants comprising risk group for dementia (Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) score ≥ 9; mean age 68.9 years, 49.5% women) from AgeWell.de were analysed. Regression models with four blocks (sociodemographic, psychosocial, factors chronic conditions)...
Abstract INTRODUCTION The societal costs of dementia and cognitive decline are substantial likely to increase during the next decades due increasing number people in older age groups. aim this multicenter cluster‐randomized controlled trial was assess cost‐effectiveness a multi‐domain intervention prevent who at risk for dementia. METHODS We used data from multi‐centric, two‐armed, ( AgeWell.de trial, ID: DRKS00013555). Eligible participants with increased baseline (Cardiovascular Risk...
Background eHealth interventions constitute a promising approach to disease prevention, particularly because of their ability facilitate lifestyle changes. Although rather recent development, might be able promote brain health and reduce dementia risk in older adults. Objective This study aimed explore the perspective general practitioners (GPs) on potentials barriers for health. Understanding GPs allows us identify chances challenges implementing apps reduction. Methods We conducted...
Background The aim of the study was to analyze impact adherence intervention components on effectiveness AgeWell.de, a multi-domain lifestyle against cognitive decline, function in everyday activities, quality life, depressiveness and social isolation. Objective Studying effect health-related outcomes. Methods Participants were aged 60–77 years at baseline risk (Cardiovascular Risk Factors, Ageing Dementia Score (CAIDE) ≥9). Adherence nutrition, enhancement physical activities training...
Targeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the large-scale initiative investigating effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate recruitment process and baseline characteristics participants gain an understanding population who engages intervention. General practitioners across five study sites recruited (aged...
Evidence on potentially modifiable risk factors for dementia is accumulating rapidly, including e.g. physical inactivity, hypertension, or diabetes. It unclear to what extent these are known among the general population in Germany. We investigated knowledge and protective openness eHealth interventions brain health older Germany.A population-based telephone survey randomly selected community-dwelling adults aged ≥ 60 years was conducted. assessed sociodemographic factors, dementia, towards...
Differences between women and men matter in the prevalence risk factors of dementia. We aimed to examine potential sex differences regarding effectiveness by running a secondary analysis AgeWell.de trial, cluster-randomized multicenter multi-domain lifestyle intervention reduce cognitive decline. Intention-to-treat analyses (n=433) (n=386) aged 60 77 years were used for models including interactions group allocation followed subgroup stratified on primary outcomes. Further, same procedure...
Noise annoyance is the second-highest cause of lost disability-adjusted life-years due to environmental noise in Europe. Evidence on exposure-response relationships (ERRs) for traffic with more accurate exposure values still needed.In an analysis population-based LIFE-Adult study Leipzig, Germany, we aimed investigate effect road, railway (train and tram), aircraft high (HA).Traffic data was taken 2012 evaluated between 2018 2021. HA defined according international standardized norms. We...
This study explores gender-specific differences in the utilization of health care services an urban population sample.As part LIFE-ADULT-Study, 2244 individuals (19-79 years) filled out a questionnaire about their use during past year. Information regarding frequency general and specialized practitioners consultation, medical advice from preventive promoting programs were analyzed.Women visited or specialists utilized prevention health-promotion more often than men. No gender found receiving...
With the outbreak of COVID-19, government measures including social distancing and restrictions contacts were imposed to slow spread virus. Since older adults are at increased risk severe disease, they particularly affected by these restrictions. These may negatively affect mental health loneliness isolation, which constitute factors for depressiveness. We aimed analyse impact perceived restriction due on depressive symptoms investigated stress as mediator in an at-risk-population Germany....
Background: Studies demonstrate associations between low social activity in older adults and cognitive decline. Little has been investigated regarding which factors are associated with at increased risk of dementia. Objective: We investigate sociodemographic, psychological, health-related, environmental Additionally, we describe the stages health behavior change, types activities, duration current level activity. Methods: used baseline data 1,015 participants from AgeWell.de trial. conducted...
While regular physical-activity (PA) is beneficial, multimorbid individuals at increased dementia risk may exhibit reduced PA levels. Thus, a more comprehensive understanding of mediating factors responsible for inactivity in this population needed. This study investigated the impact multimodal intervention on changes 24-month follow-up and associated among community-dwelling patients aged 60-77, with determined by CAIDE Dementia Risk Score. Of 1030 participants recruited, 819 completed...
Abstract Background Evidence on modifiable risk factors for dementia is accumulating rapidly, including e.g. smoking, hypertension, and diabetes. Comparing knowledge of associated with motivation to learn about reduction in different countries may support the design tailored public health campaigns. We investigated (1) differences protective between Netherlands Germany, interest (2) information brain (3) eHealth health. Materials methods Population-based telephone (Germany) or web-based...
Sleep is negatively affected by environmental noise. In the present study, we investigated self-reported high sleep disturbances (being "highly disturbed"-HSD) from road traffic (primary and secondary networks), rail (train tram) air noise in LIFE-Adult cohort study Leipzig, Germany. For this, used exposure data 2012 outcome of Wave 2 (collected during 2018-2021). HSD was determined defined according to internationally standardized norms. The highest risk for transportation noise-related...
Growing evidence suggests a protective effect of high mental demands at work on cognitive function in later life. However, corresponding associations older adults increased risk for dementia is currently lacking. This study investigates the association between and functioning population AgeWell.de-trial.Cross-sectional investigation global (Montreal Cognitive Assessment) individuals (Cardiovascular Risk Factors, Aging, Incidence Dementia (CAIDE)score ≥ 9; n = 941, age: 60-77 years)....
Unemployment is a risk factor for impaired mental health. Only little empirical information exists on possible protective effects of social welfare systems. Based large population-based sample, in this study we sought to provide detailed the association between unemployment and depression including (i) gender differences, (ii) differences subgroups unemployed (iii) relevance material resources association.
Zusammenfassung Ziel der Studie war die Untersuchung Gesundheitskompetenz (GK) sowie verschiedener Versorgungsaspekte von Long-COVID-Betroffenen. Methodik Daher wurden 407 Long-COVID Betroffene mit langanhaltender neuropsychiatrischer Symptomatik im LIFE-Studienzentrum befragt. Mittels deskriptiver, Regressionsanalysen Zusammenhänge zwischen (HLS-EU-Q16) und Versorgungsaspekten (RehaQ-N1) untersucht. Ergebnisse Die zeigen, dass 35,8% Befragten eine problematische 17,9% inadäquate GK aufwies....