A5036705093- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Viral Infections and Immunology Research
- Diet, Metabolism, and Disease
- Plant and animal studies
- Healthcare cost, quality, practices
- Botanical Studies and Applications
- Patient-Provider Communication in Healthcare
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Multiple Sclerosis Research Studies
- Immunodeficiency and Autoimmune Disorders
- Delphi Technique in Research
- Patient Dignity and Privacy
- DNA Repair Mechanisms
- T-cell and Retrovirus Studies
- Health and Medical Studies
- Immune Cell Function and Interaction
- Chronic Disease Management Strategies
- Agriculture and Biological Studies
- Aquaculture disease management and microbiota
- Virus-based gene therapy research
- Prion Diseases and Protein Misfolding
- Empathy and Medical Education
- Vaccine Coverage and Hesitancy
Martin Luther University Halle-Wittenberg
2011-2025
Luther University
2011
Abstract INTRODUCTION The societal costs of dementia and cognitive decline are substantial likely to increase during the next decades due increasing number people in older age groups. aim this multicenter cluster‐randomized controlled trial was assess cost‐effectiveness a multi‐domain intervention prevent who at risk for dementia. METHODS We used data from multi‐centric, two‐armed, ( AgeWell.de trial, ID: DRKS00013555). Eligible participants with increased baseline (Cardiovascular Risk...
Background/objectives: Attitudes towards COVID-19 vaccination vary globally, influenced by political and cultural factors. This research aimed to assess the views of people without a healthcare qualification in Europe on safety, effectiveness, necessity as well how informed they felt. The secondary outcomes focused respondents’ were affected demographic context factors included comparison country level feeling informed. Methods: A mixed-method cross-sectional online survey eight European...
Person-centred care (PCC) is a fundamental principle in general practice, emphasising practices tailored to individual patient preferences, needs, and values. Despite the importance of PCC, practitioners (GPs) face obstacles effectively implementing it, with associated factors remaining unclear. The PACE GP/FP study aims explore GPs' attitudes towards PCC facilitating or hindering its implementation daily practice across European countries. This paper outlines protocol. cross-sectional...
Introduction The COVID-19 pandemic has significantly impacted general medical practice by altering work structures and increasing teamwork while also adversely affecting the mental health of practitioners family medicine specialists. This study assesses depression, anxiety, fear levels among specialists in Europe 2 years after pandemic’s onset, it explores influencing factors. Methods observational cross-sectional included participants from 13 European countries. Data was collected May to...
Abstract Worldwide, botanical gardens cultivate around 80,000 taxa, corresponding to approximately one‐quarter of all vascular plants. Most cultivated taxa are, however, held in a small number collections, and mostly only populations. Lack genetic exchange stochastic processes populations make them susceptible detrimental effects, which should be most severe annual species, as sowing cycles are often short. In order assess whether ex situ cultivation affects diversity annuals, five arable...
Propionate has antimicrobial activity and is suggested to influence lipid metabolism. Here, we investigated the effect of propionate on metabolism gut microbiome in fructose-fed mice as a model diet-induced steatosis dysbiosis. Therefore, 48 male wild-type were fed isoenergetic diets with either 0% fructose (F–) or 40% (F+) that contained (P–) 1% (P+) for 7 weeks. Mice received F+ developed fatty livers, had fewer small intestinal proteobacteria colonic actinobacteria characterised by...
Many universities offer rural medical internships for students. The present survey was designed to show how work is perceived by students, whether these perceptions are associated with origin and previous experience, well students know regions in the vicinity of their university. In addition, were asked support inspire later a region.This cross-sectional study based on an anonymous online at Universities Halle-Wittenberg Leipzig. evaluations included descriptive statistics, statistical group...
Human endogenous retroviruses have been found to be associated with different diseases, e.g. multiple sclerosis. Most human integrated in our genome are not competent replicate and these sequences presumably silent. However, transcription of can reactivated by hypoxia. Interestingly, sclerosis has linked hypoxia since decades. As some patterns demyelination similar white matter ischemia, hypoxic damage is discussed. Therefore, we interested the association between retroviruses. a model, used...
Because antibiotic use in livestock is assumed to contribute the emerging public health crisis of resistance, alternatives are required. Phytogenic additives extensively studied due their properties. Components Agrimonia species have been reported as candidate antimicrobials that possess antioxidative and anti-inflammatory We impact procera (AP) on growth selected strains gut bacteria, effect AP mRNA abundance genes involved inflammation bacterial defense a colon carcinoma cell line, piglets...
The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. Human endogenous retroviruses (HERVs) and their superantigenic envelope protein (env) have been implicated in the RA. In present investigation, arthritogenic potential superantigen staphylococcal enterotoxin A (SEA) has investigated. bacterial was injected into right knee joint 15 Lewis rats. Further nine animals received saline. Animals were sacrificed one, five 10 days after injection, respectively. antigens CD3,...
The pathogenesis of multiple sclerosis (MS) has not been clarified. In addition to environmental factors; genetic determinants have implicated in the MS. Furthermore, endogenous retroviruses (ERV) might play a role presence oligoclonal immunoglobulin cerebrospinal fluid (CSF) is typical feature Recently, polymorphisms loci on human chromosomes 6, 14 and 18 identified as major CSF antibody levels functional relevance these single nucleotide (SNPs) remains unclear none them located an open...
Introduction General practitioners (GPs) are mostly the first point of contact for patients with health problems in Germany. There is only a limited epidemiological overview data that describe GP consultation hours based on other than billing data. Therefore, aim Saxon Epidemiological Study Practice-6 (SESAM-6) to examine frequency reasons encounter, prevalence long-term diagnosed diseases and diagnostic therapeutic decisions general practice. This knowledge fundamental identify healthcare...
The growing importance of collecting Broad Consent (BC) for research utilizing electronic health records in Germany has brought attention to the need a deeper understanding potential selection bias process. Since 2020, BeoNet-Halle outpatient database been anonymous and pseudonymous patient data from primary care specialty practices throughout Germany, with practice being an integral part this collection effort. objective pilot study is explore socioeconomic discrepancies between patients...