A5077100355- Hemophilia Treatment and Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Gut microbiota and health
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Heme Oxygenase-1 and Carbon Monoxide
- Blood groups and transfusion
- Gastrointestinal motility and disorders
- CAR-T cell therapy research
- Autoimmune Bullous Skin Diseases
- Peripheral Neuropathies and Disorders
- Microscopic Colitis
- Diabetes and associated disorders
- Inflammatory Bowel Disease
- Vitamin D Research Studies
Takeda (United States)
2019-2021
University of California, San Diego
2016-2021
Inserm
2005-2020
Université Paris Cité
2007-2020
Centre de Recherche des Cordeliers
2005-2020
Sorbonne Université
2005-2020
Gauhati Medical College and Hospital
2018
Harvard University
2010-2017
Brigham and Women's Hospital
2010-2013
Délégation Paris 5
2007-2012
Abstract The importance of gut commensal bacteria in maintaining immune homeostasis is increasingly understood. We recently described that alteration the microflora can affect a population Foxp3+Treg cells regulate demyelination experimental autoimmune encephalomyelitis (EAE), model human multiple sclerosis. now extend our previous observations on role CNS demyelination, and we demonstrate Bacteroides fragilis producing bacterial capsular polysaccharide Ag protect against EAE. Recolonization...
Several therapeutic self-proteins elicit immune responses when administered to patients. Such adverse reduce drug efficacy. To induce an response, a protein must interact with different cells, including antigen-presenting T and B cells. Each cell type recognizes distinct immunogenic patterns on antigens. Mannose-terminating glycans have been identified as pathogen-associated molecular that are essential for internalization of microbes by leading presentation. Here, we investigated the...
Abstract Innate immune mechanisms play an important role in inflammatory chronic liver diseases. In this study, we investigated the of type I or invariant NKT (iNKT) cell subsets progression nonalcoholic steatohepatitis (NASH). We used α-galactosylceramide/CD1d tetramers and clonotypic mAb together with intracytoplasmic cytokine staining to analyze iNKT cells choline-deficient l-amino acid–defined (CDAA)-induced murine NASH model human PBMCs, respectively. Cytokine secretion hepatic CDAA-fed...
Abstract Background Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, the initiation maintenance of adaptive immunity. While T cell-associated activation pathways cytokines have been identified evaluated inflammatory bowel disease (IBD) patients (Neurath, Nat Rev Gastroenterol Hepatol 14:269–78, 1989), role phagocytes are less understood. Recent reports support crucial DC subsets development...
Abstract Factor VIII (FVIII) inhibitors are anti-FVIII IgG that arise in up to 50% of the patients with hemophilia A, upon therapeutic administration exogenous FVIII. neutralize activity administered FVIII by sterically hindering its interaction molecules coagulation cascade, or forming immune complexes and accelerating clearance from circulation. We have shown previously a subset anti-factor hydrolyzes FVIII-hydrolyzing detected over inhibitor-positive severe not found inhibitor-negative...
Abstract Acquired hemophilia is a rare hemorrhagic disorder caused by the spontaneous appearance of inhibitory autoantibodies directed against endogenous coagulation factor VIII (FVIII). Inhibitory Abs also arise in patients with congenital A as alloantibodies to therapeutic FVIII. Both autoimmune and alloimmune inhibitors neutralize FVIII steric hindrance. We have described FVIII-hydrolyzing IgG 50% inhibitor-positive severe that inactivate In this study, we investigated presence acquired...
Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity therapeutic factor VIII in experimental hemophilia A. In humans, oxygenase-1 expression is modulated by polymorphisms promoter oxygenase-1-encoding gene (HMOX1). We investigated relationship between HMOX1 and inhibitor development severe performed case-control study on 99 inhibitor-positive patients 263 who did not develop inhibitors within first 150 cumulative days exposure...
We investigated the migration of intestinal immune cells to liver and their contribution alcoholic disease. In mice fed ethanol, we found that an increased number invariant natural killer T (iNKT) cells, which respond antigen presented by CD1d, migrated from mesenteric lymph nodes liver. iNKT react lipid antigens, so studied activities in with epithelial cell-specific deletion
Von Willebrand factor (VWF) has been proposed to reduce the immunogenicity of therapeutic VIII (FVIII) in patients with hemophilia A. Using FVIII-deficient mice, we compared different preparations plasma-derived (pd) and recombinant (r) FVIII. Treatment mice pdFVIII induced significantly lower titers FVIII inhibitors, as measured by ELISA vitro coagulation assays, rFVIII. Furthermore, pre-incubation rFVIII excess VWF reduced immunogenicity. Our data confirm that induces levels inhibitors...
Background The development of factor VIII (FVIII) inhibitors remains the major hurdle in clinical management patients with hemophilia A. FVIII uptake by professional antigen-presenting cells (APC) is first step involved initiation immune responses to FVIII. Studies on catabolism have highlighted role played CD91/LRP as a potential target for increasing half-life and prolonging treatment efficiency. We investigated involvement CD91 endocytosis human dendritic (DC), model APC.Design Methods...