A5006847855- DNA and Nucleic Acid Chemistry
- Antimicrobial Peptides and Activities
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Biochemical and Structural Characterization
- Receptor Mechanisms and Signaling
- Molecular Sensors and Ion Detection
- Diabetes Treatment and Management
- Synthesis and biological activity
- Crystallography and molecular interactions
- Supramolecular Chemistry and Complexes
- Protein Structure and Dynamics
- Carbohydrate Chemistry and Synthesis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Plant-Microbe Interactions and Immunity
- Glycosylation and Glycoproteins Research
- Enzyme Catalysis and Immobilization
- Porphyrin and Phthalocyanine Chemistry
- Conducting polymers and applications
- Enzyme Structure and Function
- Venomous Animal Envenomation and Studies
- Peptidase Inhibition and Analysis
- Plant Pathogens and Fungal Diseases
- Tryptophan and brain disorders
- Mycotoxins in Agriculture and Food
University of Szeged
2010-2023
In Rhizobium-legume symbiosis, the bacteria are converted into nitrogen-fixing bacteroids. many legume species, differentiation of endosymbiotic is irreversible, culminating in definitive loss their cell division ability. This terminal mediated by plant peptides produced symbiotic cells. Medicago truncatula more than ∼700 nodule-specific cysteine-rich (NCR) involved this process. We have shown previously that NCR247 and NCR335 strong antimicrobial activity on various pathogenic identified...
Our computational studies suggest that 3-substituted xanthines are good candidates for tetrad and quadruplex structures. 3-Methylxanthine (3MX) has been synthesized from 7-benzylxanthine, the existence of tetrameric octameric aggregates 3MX with NH4+, Na+ K+ ions in gas phase (MS) DMSO-d6 solution (NMR) observed. The "internal" H-bonds (N1H⋯O6) stronger than "external" ones (N7H⋯O2) these clusters (NMR).
Background: Intrinsically disordered proteins and protein regions (IDPs/IDRs) are important in diverse biological processes. Lacking a stable secondary structure, they display an ensemble of conformations. One factor contributing to this conformational heterogeneity is the proline cis/trans isomerization. The knowledge value given ratio paramount, as different states can be responsible for functions. Nuclear Magnetic Resonance (NMR) spectroscopy only method characterize two co-existing...
Medicago truncatula in symbiosis with its rhizobial bacterium partner produces more than 700 nodule-specific cysteine-rich (NCR) peptides diverse physicochemical properties. Most of the cationic NCR have antimicrobial activity and potential to tackle resistance their novel modes action. This work focuses on antibacterial NCR169 peptide derivatives as we previously demonstrated that C-terminal sequence (NCR169C17-38) has antifungal activity, affecting viability, morphology, biofilm formation...
New tetramer structures, based on 9-methylxanthine (Xa), protonated at N7 (XaH+) and 9-methyluric acid (Ua), were investigated by high-level density functional calculations. We have found that homo- heterotetrads (XaH+)4, (XaH+–Xa)2, (XaH+–Ua)2 carrying positive charges can be formed low barrier hydrogen bonds. Systems with zero charge [(Xa)4, (Xa–Ua)2, (Ua)4] also constructed, compared to the guanine tetrad [(G)4]. It was shown new tetramers bind cations anions without necessity of stacking...
The self-assembly of small molecular modules interacting through noncovalent forces is increasingly being used to generate functional structures and materials for electronic, catalytic, biomedical applications. greatest control over the geometry in H-bond supramolecular architectures, especially H-bonded polymers, can be achieved by exploiting rich programmability artificial nucleobases undergoing strong H bonds. Here N(3)-functionalized xanthine are described, which capable self-associating...
The increasing rate of fungal infections causes global problems not only in human healthcare but agriculture as well. To combat pathogens limited numbers antifungal agents are available therefore alternative drugs needed. Antimicrobial peptides potent candidates because their broad activity spectrum and diverse mode actions. model legume Medicago truncatula produces >700 nodule specific cysteine-rich (NCR) symbiosis many them have vitro antimicrobial activities without considerable...
The synthesis, chemical, physical, biological, spectroscopic and miscellaneous analytical properties of Nalkylguanine derivatives substituted at 1-, 1,N²-, N -, 3-, 3,N 7-, 7,9- 9-positions have been surveyed, mainly from the 2003-2009 period. Beyond synthetic methods, particular emphasis has given to products mutagenesis carcinogenesis, role modified fluorescent guanosines (wyosine, wyebutosine), mRNA cap structures drugs stemming N-alkylguanines. review is based on 154 references contains...
The family of cisplatin and its analogues contains some the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted understand mode action. 9-Alkylguanines featured widely in these studies as model nucleobases. This review describes both synthesis chemical, biological miscellaneous spectroscopic properties a variety transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes N-alkylguanines (mostly 9- alkylguanines) which...
A biologically active peptide toxin containing four diselenide bonds was synthesized. The network and its dynamics were disclosed using a combined NMR MD approach.
We have previously published six esterified O-acyl (EFB1) and three N-acyl fumonisin B1 derivatives extracted from rice cultures inoculated with Fusarium verticillioides, amongst these the identification of N-palmitoyl-FB1 has been clearly established in a spiking experiment. At that time, it was assumed as case O-acyl-FB1 derivatives, linoleic-, oleic- or palmitic acid esterify through OH group on 3C 5C atom carbon chain fumonisins. In our most recent experiments, we synthetically acylated...
Highly reactive glycosyl chlorides and bromides have been analysed by a routine mass spectrometric method using electrospray ionization lithium salt adduct-forming agents in anhydrous acetonitrile solution, providing salient lithiated molecular ions [M+Li]+, [2M+Li]+ etc. The role of other salts has also evaluated. is useful for accurate determination these highly sensitive compounds.
The need for novel drug delivery peptides is an important issue of the modern pharmaceutical research. Here, we test K-rich from plant dehydrin ERD14 (ERD-A, ERD-B, and ERD-C) C-terminal CPP-resembling region S100A4 (S100) using 5(6)-carboxyfluorescein (Cf) tag at N-terminus. Via a combined pH-dependent NMR fluorescence study, analyze effect Cf conjugation/modification on structural behavior, separately investigating (5)-Cf (6)-Cf forms. Flow cytometry results show that all internalize;...
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Abstract Review: 71 refs.
Glucagon is a 29-amino acid peptide hormone that produced by the post-translational cleavage of proglucagon, which 160-amino precursor polypeptide expressed in pancreatic α-cells, intestinal L cells and brain cells.In intestine brain, proglucagon catalysed PC1/3 enzyme, leading to formation glucagon-like peptide-1 (GLP-1), peptide-2 (GLP-2), glicentin oxintomodulin.GLP-1 31-amino hormonethat has approximately 50% amino sequence homology with glucagon, secreted mainly L-cells response...
The extracellular domain of the glucagon-like peptide-1 receptor, GLP-1R, is responsible for binding GLP-1, and a handful additional agonists (such as exenatide, lixisenatide, liraglutide) used daily treating type II diabetes mellitus. Lead discovery optimization, however, require studies, which, in turn, necessitate total synthesis comprising 108 residues. A protein 10-15 kDa size could be obtained either by expression E. coli or ligating solid-phase peptide (SPPS)-made fragments. However,...