A5069858313- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Rice Cultivation and Yield Improvement
- Lymphoma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Plant nutrient uptake and metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Plant responses to water stress
- RNA modifications and cancer
- Plant Molecular Biology Research
- Plant Water Relations and Carbon Dynamics
- GABA and Rice Research
- Remote Sensing in Agriculture
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Plant responses to elevated CO2
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Chromosomal and Genetic Variations
- Colorectal Cancer Treatments and Studies
Center for Cancer Research
2023-2025
National Cancer Institute
2023-2025
National Institutes of Health
2023-2025
Center for Excellence in Molecular Plant Sciences
2017-2024
Chinese Academy of Sciences
2016-2024
Shanghai Institutes for Biological Sciences
2016-2020
ORCID
2020
University of Chinese Academy of Sciences
2017-2018
State Key Laboratory of Hybrid Rice
2016
China National Hybrid Rice R&D Central Hunan Hybrid Rice Reserch Center
2016
Light inside a canopy constantly fluctuates. Under fluctuating light (FL) conditions, stomatal conductance and photosynthetic rate change. In this study, we explored whether dynamics of stomata movements upon FL influenced the water use efficiency rice in field. We used USDA-curated mini-core diversity panel consisting 204 worldwide distributed accessions. A priori model on dynamic response to was utilised identify kinetic parameters describing delays during closing (τcl) opening (τop)...
Abstract Aneuploidy results in a stoichiometric imbalance of protein complexes that jeopardizes cellular fitness. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RNA and levels, but underlying molecular mechanisms remain unknown. Here, we dissected multiple diploid vs. aneuploid cell models. We found cope with transcriptional burden increasing several degradation pathways, are consequently more sensitive perturbation degradation. At level, mitigate...
In current rice breeding programs, morphological parameters such as plant height, leaf length and width, angle, panicle architecture, tiller number during the grain filling stage are used major selection targets. However, so far, there is no robust approach to quantitatively define optimal combinations of that can lead increased canopy radiation use efficiency (RUE). Here we report development a three-dimensional photosynthesis model (3dCAP), which effectively combines vertical nitrogen...
Abstract Identifying new options to improve photosynthetic capacity is a major approach crop yield potential. Here we report that overexpression of the gene encoding transcription factor mEmBP-1 led simultaneously increased expression many genes in photosynthesis, including Chl a,b-binding proteins (Lhca and Lhcb), PSII (PsbR3 PsbW) PSI reaction center subunits (PsaK PsaN), chloroplast ATP synthase subunit, electron transport components (Fd1 PC), also Calvin–Benson–Bassham cycle, those...
Abstract Weed species are detrimental to crop yield. An understanding of how weeds originate and adapt field environments is needed for successful management reduction herbicide use. Although early flowering one the weed trait syndromes that enable ruderal overcome frequent disturbances, underlying genetic basis poorly understood. Here, we establish Cardamine occulta as a model study ruderality. By genome assembly QTL mapping, identify impairment vernalization response regulator gene FLC...
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies. However, its application in solid tumors remains limited because single targets are unlikely to suffice due tumor heterogeneity and off-tumor toxicities. To overcome these obstacles, we developed LogiCAR designer, a computational approach that utilizes single-cell transcriptomics data from patient systematically identify cancer-specific circuits with logic gates ("AND," "OR," "NOT")...
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