A5010277509- Health Systems, Economic Evaluations, Quality of Life
- Dental Research and COVID-19
- Health Policy Implementation Science
- Dental Health and Care Utilization
- Meta-analysis and systematic reviews
- Mental Health and Patient Involvement
- COVID-19 Clinical Research Studies
- Social Media in Health Education
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Oral microbiology and periodontitis research
- Delphi Technique in Research
- Patient-Provider Communication in Healthcare
- Antibiotic Use and Resistance
- Statistical Methods in Clinical Trials
- Retinal Diseases and Treatments
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Dental Anxiety and Anesthesia Techniques
- Urologic and reproductive health conditions
- Retinal Imaging and Analysis
- Patient Satisfaction in Healthcare
- Retinal and Optic Conditions
- Primary Care and Health Outcomes
- Pelvic floor disorders treatments
University of Aberdeen
2016-2025
SickKids Foundation
2023
Research Network (United States)
2023
University of Ottawa
2023
UCLouvain
2023
Western University
2023
Ottawa Hospital
2023
CHU Dinant Godinne UCL Namur
2023
Hospital for Sick Children
2023
University of Lisbon
2015-2016
Periodontal disease is preventable but remains the most common oral worldwide, with major health and economic implications. Stakeholders lack reliable evidence of relative clinical effectiveness cost-effectiveness different types hygiene advice (OHA) optimal frequency periodontal instrumentation (PI).To test assess value following strategies: personalised OHA versus routine OHA, 12-monthly PI (scale polish) compared 6-monthly PI, no PI.Multicentre, pragmatic split-plot, randomised open trial...
Abstract Objective To characterise the nutritional status and to identify malnutrition-associated variables of older adults living in Portuguese nursing homes. Design Cross-sectional study. Data on demographic socio-economic characteristics, self-reported morbidity, eating-related problems, status, cognitive function, depression symptoms, loneliness feelings functional were collected by trained nutritionists through a computer-assisted face-to-face structured interview followed standardised...
This report presents the explanation and elaboration paper for CONSORT (Consolidated Standards of Reporting Trials) 2010 SPIRIT (Standard Protocol Items: Recommendations Interventional 2013 extensions factorial trials. Factorial trials involve randomising participants to more than one intervention, often with aim evaluating multiple interventions in study or assessing whether treatments interact. The statements have been extended allow unique features design. items along detailed...
Abstract Background Guidance exists to inform the content of statistical analysis plans in clinical trials. Though not explicitly stated, this guidance is generally focused on trials which randomization units are individual patients and groups patients. There critical considerations for cluster randomized trials, such as accounting clustering, risk imbalances between arms due post-randomization recruitment, need use small sample corrections when number clusters small. Methods This paper...
Unless women start effective contraception after oral emergency contraception, they remain at risk of unintended pregnancy. Most in the UK obtain from community pharmacies. We hypothesised that pharmacist provision progestogen-only pill as a bridging interim method with plus an invitation to sexual and reproductive health clinic, which all methods are available, would result increased subsequent use contraception.We did pragmatic cluster-randomised crossover trial 29 pharmacies among...
Importance Trial protocols outline a trial’s objectives as well the methods (design, conduct, and analysis) that will be used to meet those objectives, transparent reporting of trial ensures are clear facilitates appraisal regarding suitability study methods. Factorial trials, in which 2 or more interventions assessed same set participants, have unique methodological considerations. However, no extension Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013...
Background New surgical approaches for apical prolapse have gradually been introduced, with few prospective randomised controlled trial data to evaluate their safety and efficacy compared traditional methods. Objective To compare uterine preservation vaginal hysterectomy in women abdominal procedures vault terms of clinical effectiveness, adverse events, quality life cost-effectiveness. Design Two parallel trials (i.e. Uterine Vault). Allocation was by remote web-based randomisation (1 : 1...
Background Traditionally, patients are encouraged to attend dental recall appointments at regular 6-month intervals, irrespective of their risk developing disease. Stakeholders lack evidence the relative effectiveness and cost-effectiveness different strategies optimal interval for maintenance oral health. Objectives To test assess cost–benefit intervals over a 4-year period. Design Multicentre, parallel-group, randomised controlled trial with blinded clinical outcome assessment 4 years...
To evaluate the diagnostic accuracy of routinely used tests visual function and retinal morphology compared with fundus fluorescein angiography (FFA) to detect onset active macular neovascularization in unaffected fellow eyes patients unilateral neovascular age-related degeneration (nAMD). Prospective cohort study conducted 24 eye clinics United Kingdom over 3 years. Older adults (>50 years) recently diagnosed nAMD a (study) free nAMD. Self-reported vision, Amsler, clinic-measured acuity...
There are few data on patient and public involvement (PPI) in pragmatic trials. We aimed to describe the prevalence nature of PPI within trials, variation by trial characteristics compare reported authors that publications.We applied a search filter identify trials published from 2014 2019 MEDLINE. invited corresponding participate an online survey about their specific trial.Of 3163 invited, 2585 invitations were delivered, 710 (27.5%) unique completed survey; 334 (47.0%) conducted PPI....
Worldwide we are facing a serious demographic challenge due to the dramatic growth of population over 60 years. It is expected that proportion this will nearly double from 12 22 %, between 2015 and 2050. This shift comes with major health socio-economic concerns. Nutrition fundamental determinant both disease its role in extending healthy lifespan object considerable research. Notably, malnutrition one main threats quality life among elderly. Therefore, knowledge about nutritional status...
Abstract Introduction The COVID-19 pandemic brought about seismic change for dentistry including the direction to provide remote advice and prescribe analgesia antimicrobials. possibilities care have widened, but impact of both restrictions remobilisation on antibiotic prescribing is not known. Aims To report dental prescriptions explore dentists' intentions attitudes towards prescribing. Design setting Public Health Scotland national claims data are reported alongside an online survey...
Dental caries is one of the most prevalent non-communicable disease globally and can have serious health sequelae impacting negatively on quality life. In UK adults experience dental during their lifetime 2009 Adult Health Survey reported that 85% at least restoration. Conservative removal tooth tissue for both primary secondary reduces risk failure due to tooth-restoration, complex fracture as well remaining surfaces being less vulnerable further caries. However, despite its prevalence...
Abstract Background Progression of dental caries can result in irreversible pulpal damage. Partial pulpitis is the initial stage this damage, confined to coronal pulp whilst radicular shows little or no sign infection. Preserving with sustained vitality and developing minimally invasive biologically based therapies are key themes within contemporary clinical practice. However, root canal treatment involving complete removal often only option (other than extraction) given patients pulpitis,...