A5027358698- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Crystallography and molecular interactions
- Cyclopropane Reaction Mechanisms
- Organometallic Complex Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Catalytic Cross-Coupling Reactions
- Asymmetric Hydrogenation and Catalysis
- Carbohydrate Chemistry and Synthesis
- Biochemical and Molecular Research
- Oxidative Organic Chemistry Reactions
- Synthesis and Biological Evaluation
- Advanced Synthetic Organic Chemistry
- Quinazolinone synthesis and applications
- Asymmetric Synthesis and Catalysis
- Microbial Natural Products and Biosynthesis
- Synthesis and biological activity
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Organoboron and organosilicon chemistry
- Fuel Cells and Related Materials
Hanzhong People's Hospital
2023-2024
Boston College
2019-2023
Nanjing University
2015-2016
Chimie Biologique pour le Vivant
2015-2016
In the past decade, direct C-H arylation of indoles has been developed with high selectivity at C2 and C3 positions via transition-metal-catalyzed cross-coupling reactions. Here we show that activation can be directed to C7 position in Pd-catalyzed coupling arylboronic acids. The key this regioselectivity is appropriate choice a phosphinoyl directing group pyridine-type ligand presence Pd(OAc)2 catalyst. This previously elusive transformation should provide insight for design other...
Amines emerge, as copper bides its time Concurrent operation of two or more catalytic cycles requires a delicate balance relative rates. Zhang et al. developed an amine synthesis in which allenes and nitriles are coupled under reductive conditions. A catalyst was charged with successively borylating the allene, coupling intermediate to nitrile, then enantioselectively reducing that next amine. However, formation reaction copper-boryl complex were too slow competing hydride. By adding...
Abstract An operationally simple in situ protection/deprotection strategy that significantly expands the scope of kinetically controlled catalytic Z ‐ and E ‐selective olefin metathesis is introduced. Prior to addition a sensitive Mo‐ or Ru‐based complex, treatment hydroxy‐ carboxylic‐acid‐containing with commercially available HB(pin) readily accessible HB(trip) 2 (pin=pinacolato, trip=2,4,6‐tri(isopropyl)phenyl) for 15 min sufficient efficient generation desired product. Routine workup...
Stereochemically defined trisubstituted alkenes with a bromide and methyl group at terminus can be readily stereoretentively derivatized through catalytic cross-coupling, affording unsaturated fragments found in many bioactive natural products. A direct method for generating such entities would by stereocontrolled cross-metathesis (CM). Such methods are scarce however. Here, we present stereoretentive strategy CM between tri-, Z- or E-di, monosubstituted olefins E-2-bromo-2-butene, an...
Catalytic cross-metathesis (CM) reactions that can generate trisubstituted alkenes in high stereoisomeric purity are important but remain limited scope. Here, CM introduced Z-trisubstituted α-methyl, α,β-unsaturated, alkyl and aryl esters, thiol acid fluorides. Transformations promoted by a Mo bis-aryloxide, monoaryloxide pyrrolide, or chloride complex; air-stable commercially available paraffin tablets containing complex may also be used. Alkyl, aryl, silyl carboxylic esters as well...
A Pd(<sc>ii</sc>)-catalyzed selective β-arylation of <italic>O</italic>-methyl ketoximes was developed using iodoarenes as the coupling partners.
Abstract Ethylene is the byproduct of olefin metathesis reactions that involve one or more terminal alkenes. Its volatility reason why many cross‐metathesis ring‐closing processes, which are reversible transformations, efficient. However, because ethylene can be converted to a methylidene complex, highly reactive but relatively unstable species, its concentration impact in other ways. In some cases, introducing excess increase reaction rate owing faster catalyst initiation. and derived...
‘Memory of chirality’ (MOC) is an important concept for the development efficient asymmetric transformations. However, phenomenon MOC in C–H functionalization still rare. In past decades, three types intramolecular amination involving insertion metal nitrenoids, 1-aza-2-azoniaallene salts, and benzamides to construct N-heterocyclic compounds have been developed Du Bois, Brewer, our group, respectively. these reactions, formation a C–N bond does not result loss stereochemical information at...
Abstract An operationally simple in situ protection/deprotection strategy that significantly expands the scope of kinetically controlled catalytic Z ‐ and E ‐selective olefin metathesis is introduced. Prior to addition a sensitive Mo‐ or Ru‐based complex, treatment hydroxy‐ carboxylic‐acid‐containing with commercially available HB(pin) readily accessible HB(trip) 2 (pin=pinacolato, trip=2,4,6‐tri(isopropyl)phenyl) for 15 min sufficient efficient generation desired product. Routine workup...
Background: Severe acute respiratory syndrome coronavirus 2 main protease (SARSCoV- Mpro) has been shown to be an effective target for inhibiting novel coronaviruses, which can used as a crucial breakthrough developing drugs treat the disease 2019 (COVID-19). Methods: To design SARS-CoV-2 Mpro inhibitors, we conducted 3D-QSAR, molecular docking, and dynamics (MD) simulation on 64 quinazolin-4-one derivatives. Results: Comparative field analysis (CoMFA) model (q2 = 0.590, R2 0.962),...
Abstract Review: [25 refs.
Abstract This protocol provides a powerful tool for late stage functionalization of complex molecules.
Abstract Key to the regioselectivity is choice of phosphinoyl directing group and a pyridine‐type ligand in presence Pd(OAc) 2 as catalyst.