A5014196412- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
- Diet and metabolism studies
- Kawasaki Disease and Coronary Complications
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Influenza Virus Research Studies
- Neonatal and fetal brain pathology
- Genomic variations and chromosomal abnormalities
- Gastrointestinal motility and disorders
- Otolaryngology and Infectious Diseases
- Advanced Neuroimaging Techniques and Applications
- Genetic and Kidney Cyst Diseases
- Vascular Malformations and Hemangiomas
- Cardiovascular Disease and Adiposity
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Infectious Diseases and Tuberculosis
- Cardiac Structural Anomalies and Repair
- Inflammasome and immune disorders
- Coronary Artery Anomalies
- Travel-related health issues
- Tuberous Sclerosis Complex Research
Severance Hospital
2017-2023
Yonsei University
2017-2023
Kyung Hee University Hospital at Gangdong
2015-2021
Kyung Hee University Dental Hospital
2016
Southerners on New Ground
2015
Kyung Hee University
2014
We intended to evaluate diagnostic utility of a targeted gene sequencing by using next generation (NGS) panel in patients with intractable early-onset epilepsy (EOE) and find the efficient analytical step for increasing diagnosis rate. assessed 74 EOE whose seizures started before 3 years age customized NGS that included 172 genes. Single nucleotide variants (SNVs) exonic chromosomal copy number variations (CNVs) were intensively examined our pipeline crosschecked commercial or pre-built...
Background and Purpose Perampanel is the first α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonist developed to treat epilepsy.The effects of either rapid or slow dose titration on adverse events remain be elucidated.Methods Eighty-five patients received perampanel between March 2016 August 2016.Patients were divided into two groups according their dosing schedule: (2-mg increments at intervals 1 2 weeks) least 3 weeks).Seizure frequency analyzed over months....
This study aimed to assess the long-term outcomes of vagus nerve stimulation (VNS) in children with pharmaco-resistant Dravet syndrome (DS).We enrolled 22 patients DS who underwent VNS implantation at Severance Children's Hospital from March 2005 October 2020. Efficacy and tolerability were assessed 3, 6, 12, 18, 24, 30, 36 months after implantation. was measured as percentage reduction seizure frequency each follow-up compared baseline (pre-implantation) values.Median patient age 10.0 years...
This study aimed to investigate the functional network effects of corpus callosotomy (CC), a well-recognized palliative surgical therapy for patients with Lennox-Gastaut syndrome (LGS). Specifically, we sought gain insight into CC on LGS remission, based brain networks in by calculating metrics and evaluating measures before after surgery.Electroencephalographic recordings made during preoperative 3-month postoperative states 14 who had undergone successful were retrospectively analyzed....
This study determined the 24-month outcomes of perampanel treatment in children and adolescents with epilepsy. The percentage ≥ 50% responders was 47.3% (139/294) at 12 months 49.0% (144/294) 24 months. A 100% reduction seizures for more than observed 12.2% (36/294). Discontinuation occurred 39.8% (117/294). most common reason discontinuation adverse events (29.1%, 34/117). Baseline seizure frequency higher aged < years patients years; however, did not significantly differ between two...
목적: 본 연구는 인플루엔자 B 바이러스에 대한 oseltamivir의 효능을 알아보고자 치료군과 비치료군간의 임상적 특징의 차이를 비교하였다. 방법: 2012년 1월부터 7월까지 입원하거나 외래 진료실을 방문하여 감염된 소아 환자를 대상으로 후향적으로 의무기록을 분석하였다. 결과: 의한 폐렴, 급성 기관지염, 급성세기관지염, 크룹으로 진단된 72명의 평균 나이는 $3.6{\pm}2.8$ 세 였다. oseltamivir 치료군은 38명(53%), 비치료군은 34명(47%)이었고 치료 시기를 고려하지 않았을 때 두 군의 입원 기간( $4.18{\pm}2.10$ 일 vs $4.79{\pm}1.49$ 일, P=.17), 총 발열 $5.32{\pm}2.07$ $6.41{\pm}3.25$ P=.09)을 포함한 양상에 유의한 차이가 없었다. 비치료군, 48시간 이내 치료군, 이후 치료군간의 비교에서 3세 이하의 환자들을 군간의 비교에서도 결론: Oseltamivir 복용 전 특성에서...
목적: 가와사끼병(Kawasaki disease, KD)은 여러 기관을 침범하여 다양한 임상적 징후를 나타낸다. 징후들의 중증도와 관상동맥병변(coronary artery lesion, CAL)과의 연관성은 잘 알려져 있지않다. 본 연구는 심한 피부병변이나 관절염을 가진 환자군들이 나타내는 임상 양상들과 CAL의 발생 위험도를 평가하고자 하였다. 방법: 면역글로불린을 투여 받은 KD 환아 220명을 대상으로 후향적으로 조사하였다. 피부병변이있는 환자군(52명)과 경하거나 피부 병변이 없는 환자군(168명), 관절염이 있는 환자군(6명)과 환자군(124명)간의 양상 및 검사실 소견을 각각 비교하였다. 결과: 전체 환자들의 평균 나이는 2.23±1.87세였고 남아와 여아의 비는 1.5:1 (138/82)이었다. 220명 중에 52명(23.6%)은 CAL을 동반하였고 29명(13.2%)은 비전형적 KD를 보였다. 동반한 군이 나이가 많고 발열 기간이 길었으며 면역글로불린 치료에...
Hypoglossal nerve (cranial XII) palsy (HNP) is a neurological disorder that causes tongue deviation, atrophy, and muscle fiber contraction on the affected side.Tumors are most common cause of HNP, followed by trauma, vascular abnormalities, autoimmune diseases, rarely, viral or bacterial infection [1,2].Isolated HNP without other symptoms rare.It often accompanied cranial disorders; intramedullary lesions typically involve adjacent nuclei tracts, peripheral generally affect lower nerves...
Introduction: There are several reports that coronary artery lesions (CALs) increased/or not increased in patients who predominantly showed arthritis with Kawasaki disease (KD). Patients eczematoid skin which seem like atopic dermatitis have been reported association CALs. We intended to evaluate the risk of development CALs two different phenotypes. Materials and methods: retrospectively reviewed medical records 220 diagnosed as KD received IVIG treatment Kyung Hee University Hospital at...
Abstract This study determined a 24-month outcome of perampanel (PER) treatment in children and adolescents with drug-resistant epilepsy. The percentage ≥50% responders was 47.3% at 12 months 49.0% 24 months. A 100% reduction seizures for more than observed 36 patients (12.2%). Discontinuation occurred 117 (39.8%). most common reason discontinuation adverse events (34/117 patients, 11.6%). Baseline seizure frequency higher aged <12 years ≥12 years, however, the did not significantly...