A5089221088- Food Allergy and Anaphylaxis Research
- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Treatment and Research
- Reproductive Health and Contraception
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Pelvic floor disorders treatments
- Health Systems, Economic Evaluations, Quality of Life
- Urinary Bladder and Prostate Research
- Schizophrenia research and treatment
- Trauma Management and Diagnosis
- Multiple Myeloma Research and Treatments
- Maternal and Perinatal Health Interventions
- Oral Health Pathology and Treatment
- Viral-associated cancers and disorders
- Bladder and Urothelial Cancer Treatments
- Oral microbiology and periodontitis research
- Laser Applications in Dentistry and Medicine
- Urinary Tract Infections Management
- Balance, Gait, and Falls Prevention
- Surgical Sutures and Adhesives
- Dysphagia Assessment and Management
- Pediatric health and respiratory diseases
- Drug-Induced Adverse Reactions
RTI Health Solutions
2017-2025
RTI International
2016-2021
Triangle
2021
In the ARAMIS trial, darolutamide plus androgen deprivation therapy (ADT) versus placebo ADT significantly improved metastasis-free survival (MFS), overall (OS) and time to pain progression in patients with non-metastatic castration-resistant prostate cancer (nmCRPC). Herein, we present analyses of patient-reported health-related quality life (HRQoL) outcomes.This double-blind, placebo-controlled, phase III trial randomised nmCRPC prostate-specific antigen doubling ≤10 months 600 mg (n =...
Parkinson's disease-related psychosis increases patients' risk of falls. Pimavanserin is an atypical antipsychotic approved in the USA 2016 for treatment hallucinations and delusions associated with psychosis.We aimed to compare falls/fractures among patients treated pimavanserin vs other antipsychotics.We identified a cohort aged ≥ 40 years initiating either or comparator (clozapine, quetiapine, risperidone, olanzapine, aripiprazole, brexpiprazole) US commercial insurance supplementary...
5000 Background: DARO is a structurally distinct androgen receptor antagonist for which in vitro and phase 1/2 studies suggest low risk of adverse events (AEs) drug–drug interaction. In the ARAMIS study nmCRPC, metastasis-free survival (MFS) was significantly prolonged vs placebo (PBO) (40.4 18.4 mo; hazard ratio [HR] 0.41; 95% confidence interval [CI] 0.34–0.50; P < 0.001) interim overall (OS) favored (HR 0.71; CI 0.50–0.99; = 0.045). Methods: 1509 pts were randomized 2:1 to 600 mg (two...
Blocking muscarinic receptors could have an effect on cardiac function, especially among elderly patients with overactive bladder (OAB).To investigate the risk of cardiovascular (CV) events in users antimuscarinic drugs to treat OAB.Cohort study new darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, or trospium, 18 years older, United Kingdom's Clinical Practice Research Datalink (CPRD), 2004-2012.Using tolterodine as reference, we estimated propensity-score-stratified...
A pilot survey described the characteristics of anaphylactic events occurring in an initial set participating U.S. schools during 2013–2014 school year. This was subsequently readministered to large districts, which were underrepresented results. cross-sectional administered that EPIPEN4SCHOOLS® program (Mylan Specialty L.P., Canonsburg, PA) assess events. Data from districts added findings this comprehensive combined analysis. total 1,140 reported among 6,574 responding schools. Of 1,063...
Objective Evaluate whether the risk of falls and fractures differs between patients with Parkinson disease psychosis (PDP) (PD) without at similar stages. Methods Patients PD were identified in Medicare claims databases (2008–2018) followed from first diagnosis date during study period. a subsequent included PDP group. propensity score-matched based on characteristics within blocks time since cohort entry. The incidence rates (IRs), expressed per 100 person-years, 95% confidence intervals...
Study Objective To estimate the incidence of 10 common cancers among patients treated with antimuscarinic medications for overactive bladder (AMOABs). Design Retrospective cohort study. Data Source United Kingdom's Clinical Practice Research Datalink. Patients A total 119,912 adults no previous cancer diagnosis who were new users AMOABs—darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, or trospium—between January 2004 and December 2012. Measurements Main Results Sex-specific...
Intrauterine devices are effective and safe, long-acting reversible contraceptives, but the risk of uterine perforation occurs with an estimated incidence 1 to 2 per 1000 insertions. The European Active Surveillance Study for Devices, a prospective observational study that enrolled 61,448 participants (2006-2012), found women breastfeeding at time device insertion or inserted ≤36 weeks after delivery had higher perforation. Association Uterine Perforation Expulsion Device (APEX-IUD) was Food...
The efficacy and safety of regorafenib have been demonstrated in phase 3 trials for multiple tumor types, including metastatic colorectal cancer (mCRC) (CORRECT [NCT01103323]; CONCUR [NCT01584830]), advanced gastrointestinal stromal (GIST) (GRID [NCT01271712]), hepatocellular carcinoma (HCC) (RESORCE [NCT01774344]). objective this post hoc exploratory analysis was to explore the impact on delaying health-related quality life (HRQOL) deterioration across these types. HRQOL data (assessed with...
Background: Allergy guidelines recommend intramuscular injection of epinephrine as a first-line therapy to treat anaphylaxis. In the community, can be promptly administered with an auto-injector (EAI). Unites States, EPIPEN4SCHOOLS® program (Mylan Specialty L.P., Canonsburg, PA) provides EpiPen® (epinephrine injection) Auto-Injectors qualifying public and private schools. An initial pilot survey was used assess characteristics anaphylactic events occurring in set participating schools during...