A5060850737- Bladder and Urothelial Cancer Treatments
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Drug-Induced Hepatotoxicity and Protection
- Heart Failure Treatment and Management
- Congenital Heart Disease Studies
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Appendicitis Diagnosis and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pharmacological Effects and Assays
- Bone health and treatments
- Healthcare Policy and Management
- Liver Disease and Transplantation
- Blood Pressure and Hypertension Studies
- Medication Adherence and Compliance
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Impact on Reproduction
- Metastasis and carcinoma case studies
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacovigilance and Adverse Drug Reactions
RTI Health Solutions
2009-2024
Baylor College of Medicine
2016-2019
University of California Davis Medical Center
2016
Research Triangle Park Foundation
2013
RTI International
2013
Objective: To determine the prevalence of uncontrolled asthma in patients who are visiting their primary care provider for any reason.Research design and methods: This multisite, cross-sectional survey was conducted between January 25 May 2, 2008. Participants aged ≥18 years were recruited from 35 sites. Eligible participants presented to office acute medical, routine, follow-up, or nonmedical reason; had a self-reported physician diagnosis asthma; used medication treat past year; no history...
Monovalent booster/additional doses of COVID-19 vaccines were first authorized in August 2021 the United States. We evaluated real-world effectiveness receipt a monovalent dose vaccine compared with receiving primary series without dose. Cohorts individuals after complete identified 2 administrative insurance claims databases (Optum, CVS Health) supplemented state immunization information system data between and March 2022. Individuals but one-to-one matched to boosted on calendar date,...
COVID-19 vaccines are authorized for use in children the United States; real-world assessment of vaccine effectiveness is needed. This study's objective was to estimate receiving a complete primary series monovalent BNT162b2 (Pfizer-BioNTech) US children.
Study Objective To estimate the incidence and relative risk of a hospitalization or emergency visit for noninfectious liver injury in users eight oral antimicrobials—amoxicillin, amoxicillin‐clavulanic acid, clarithromycin, cefuroxime, doxycycline, levofloxacin, moxifloxacin, telithromycin—compared with nonusers these antimicrobials. Design Retrospective, observational cohort study nested case‐control analysis. Data Source HealthCore Integrated Research Database. Patients Adults continuous...
Purpose To describe the use of antimuscarinic drugs to treat overactive bladder (OAB) in Denmark, Sweden, and United Kingdom (UK). Methods We identified new users darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, trospium aged 18 years or older from Danish National Registers (2004–2012), Swedish (2006–2012), UK Clinical Practice Research Datalink (2004–2012). Users were followed until disenrollment, cancer diagnosis, death, study end. Treatment episodes, by linking consecutive...
Abstract Purpose Strategies to identify and validate acute myocardial infarction (AMI) stroke in primary‐care electronic records may impact effect measures, but an unknown extent. Additionally, the validity of cardiovascular risk factors that could act as confounders studies on those endpoints has not been thoroughly assessed United Kingdom Clinical Practice Research Datalink's (CPRD's) GOLD database. We explored algorithms outcomes evaluated different outcome‐identification strategies using...
Purpose To describe the characteristics of new users cilostazol in Europe with aim to support evaluation its benefit/risk as used regular clinical practice before implementation labeling changes recommended by European Medicines Agency. Methods New were identified populations enrolled five health automated databases UK (The Health Improvement Network [THIN]), Spain (EpiChron cohort and Information System for Research Primary Care [SIDIAP]), Sweden (National Registers), Germany (German...
Study Objective To estimate the incidence of 10 common cancers among patients treated with antimuscarinic medications for overactive bladder (AMOABs). Design Retrospective cohort study. Data Source United Kingdom's Clinical Practice Research Datalink. Patients A total 119,912 adults no previous cancer diagnosis who were new users AMOABs—darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, or trospium—between January 2004 and December 2012. Measurements Main Results Sex-specific...
We conducted a cohort study of acute, noninfectious liver injury among oral antimicrobial users. Potential cases were identified in the HealthCore Integrated Research Database (HIRDSM) population between July 1, 2001, and March 31, 2009, using ICD-9-CM codes primarily for acute subacute necrosis liver, hepatic coma, unspecified hepatitis. Liver test results used to confirm case status according published criteria. Two physician reviewers experienced studying (blinded drug exposures)...
<title>Abstract</title> Background Many neurologic or immune-mediated conditions have been evaluated as potential adverse events (AEs) in coronavirus disease 2019 (COVID-19) vaccine safety surveillance. To contextualize United States (US) surveillance findings, it is important to quantify the risk of AEs associated with COVID-19 diagnosis among adults US before introduction vaccines. Methods Cohort and self-controlled interval (SCRI) designs were used 2 administrative claims data...
With data from 2 US claims databases (Optum, CVS Health) supplemented with Immunization Information System COVID 19 vaccine records, we evaluated overall and time-specific effectiveness (VE) of an initial primary series for 3 monovalent vaccines—BNT162b2, mRNA-1273, JNJ-7836735—in adults (18-64 years). Vaccinated individuals were matched to unvaccinated comparators, estimated VE against any medically diagnosed hospital/emergency department (ED)-diagnosed 19. Additionally, by era predominant...
Abstract Purpose This study evaluated the association between coronavirus disease 2019 (COVID-19) diagnosis and adverse events (AEs), including cardiovascular AEs appendicitis, in US adults before introduction of COVID-19 vaccines. Real-world studies after suggest that diagnoses frequently occur on same day may be a source bias. Methods Cohort self-controlled risk interval (SCRI) designs were used 2 administrative claims data sources—Merative™ MarketScan® (ages 18-64 years) Medicare ≥ 65...
Abstract Purpose The purpose of the study is to evaluate effectiveness risk minimization measures—labeling changes and communication health care professionals—recommended by European Medicines Agency for use cilostazol treatment intermittent claudication in Europe. Methods Observational Health Improvement Network (United Kingdom), EpiChron Cohort (Spain), SIDIAP Swedish National Databases, GePaRD (Germany). Among new users cilostazol, we compared prevalence conditions targeted measures...
ABSTRACT Importance COVID-19 vaccines are authorized for use in children the United States; real-world assessment of vaccine effectiveness is needed. Objective To estimate receiving a complete primary series monovalent BNT162b2 (Pfizer-BioNTech) US children. Design A cohort study aged 5–17 years vaccinated with matched unvaccinated Setting Participants identified Optum and CVS Health insurance administrative claims databases were linked Immunization Information System (IIS) vaccination...