A5074882008- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- Ethics in Clinical Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Patient-Provider Communication in Healthcare
- Polyomavirus and related diseases
- Cancer Risks and Factors
- Antenna Design and Analysis
- Full-Duplex Wireless Communications
- Prenatal Screening and Diagnostics
- Viral Infections and Outbreaks Research
- Iron Metabolism and Disorders
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Nail Diseases and Treatments
- Plant Virus Research Studies
- Cervical Cancer and HPV Research
- Cardiovascular Health and Risk Factors
- Estrogen and related hormone effects
- Health Literacy and Information Accessibility
- Genetically Modified Organisms Research
- Economic and Financial Impacts of Cancer
- Genital Health and Disease
RTI Health Solutions
2021-2025
Triangle
2023
Columbia University
2016-2019
Columbia University Irving Medical Center
2017-2018
Herbert Irving Comprehensive Cancer Center
2017
Universidad de Antioquia
2008
Women with atypical hyperplasia and lobular or ductal carcinoma in situ (LCIS/DCIS) are at increased risk of developing invasive breast cancer. Chemoprevention selective estrogen receptor modulators aromatase inhibitors can reduce cancer risk; however, uptake is estimated to be less than 15% these populations. We sought determine which factors associated chemoprevention a population women hyperplasia, LCIS, DCIS. diagnosed hyperplasia/LCIS/DCIS between 2007 2015 without history were...
Breast cancer chemoprevention can reduce breast incidence in high-risk women; however, is underutilized the primary care setting. We conducted a pilot study of decision support tools among women and their providers (PCPs). The intervention included aid (DA) for women, RealRisks, provider-centered tool, Cancer Risk Navigation (BNAV). Patients completed validated surveys at baseline, after RealRisks PCP clinical encounter or 6-months. Referral consultation uptake were assessed via electronic...
Merkel cell carcinoma (MCC) is a rare, aggressive, cutaneous neuroendocrine neoplasm with annual incidence rates of 0.13-1.6 cases/100,000/year worldwide as 2018. Chemotherapy for metastatic MCC (mMCC) has high objective response (ORRs), but responses are not durable and overall survival (OS) poor. Avelumab (anti-programmed death-ligand 1) demonstrated meaningful benefit in clinical trials mMCC. This study investigated real-world outcomes avelumab-treated patients advanced (stage IIIB/IV) US...
Ketoconazole was administered orally to 13 patients with paracoccidioidomycosis. Therapy consisted of 200 mg per day for periods ranging from three 12 months. All improved markedly, healing pulmonary, mucosal, and skin lesions. Patients exhibiting the latter two manifestations began improve weeks after therapy, occurred within Pulmonary lesions regressed at a slower pace healed by fibrosis. Mycologic tests have corroborated clinical improvement. Adverse effects were not observed; monitoring...
Abstract Background: Potential harms of screening mammography include false positive results, such as recall breast imaging or biopsies. Methods: We recruited women undergoing at Columbia University Medical Center in New York, York. They completed a questionnaire on cancer risk factors and permitted access to their medical records. Breast status was determined using the Gail model family history screener. High defined 5-year invasive ≥1.67% eligible for BRCA genetic testing. False results...
Chemoprevention using selective estrogen receptor modulators and aromatase inhibitors has been shown to reduce invasive breast cancer incidence in high-risk women. Despite this evidence, few women who are eligible for chemoprevention utilize it as a risk-reducing strategy. Reasons low uptake include inadequate knowledge about among patients healthcare providers, concerns side effects, time constraints during the clinical encounter, competing comorbidities.
In spite of implementation cytology-based cervical cancer screening in Colombia, mortality rates remain stable. The description factors associated to pre-neoplasic lesions is needed establish strategies for prevention.The prevalence epithelial squamous cell abnormalities was determined explore the association cytology with described risk factors.This population-based, cross-sectional study included 739 women randomly selected by age. A validated face-to-face questionnaire and conventional...
<b><i>Background/Aims:</i></b> Ashkenazi Jews have a 1:40 prevalence of <i>BRCA1/2</i> mutations. Orthodox are an understudied population with unique cultural and religious factors that may influence genetic testing uptake. <b><i>Methods:</i></b> Using mixed-methods approach, we conducted cross-sectional survey focus groups among Jewish women in New York/New Jersey to explore affecting decision-making about<i>...
1586 Background: The U.S. Preventive Services Task Force (USPSTF) recommends that women who meet family history criteria for hereditary breast and ovarian cancer (HBOC) be referred genetic counseling. However, HBOC testing is under-utilized, particularly among racial/ethnic minorities. We evaluated different methods of intake, including a validated screener, documentation in the electronic health record (EHR), web-based decision aid (DA). Methods: Among undergoing screening mammography, we...
e13038 Background: Breast cancer risk assessment and chemoprevention with anti-estrogens among high-risk women are underutilized. We developed web-based decision support tools for women, RealRisks, their primary care providers (PCPs), BNAV, which integrated into clinic workflow. Methods: conducted a pilot study in 50 who were found to have 5-year of invasive breast ≥1.67% according the Gail model during screening mammography. RealRisks includes modules on chemoprevention, as well interactive...
e13044 Background: One of the barriers to chemoprevention uptake among high-risk women is lack routine breast cancer risk assessment in primary care setting. We calculated using Breast Cancer Surveillance Consortium (BCSC) model, which accounts for age, race/ethnicity, first-degree family history cancer, benign disease, and mammographic density, data collected from electronic health record (EHR) compared self-report. Methods: Among undergoing screening mammography, we information EHR a...
Abstract Objective - High rates of screening mammography have been reported among Hispanic women in the U.S. However, a potential harm is false positive result with recall breast imaging or biopsy. Our objective was to identify factors associated results on predominantly population New York City. Methods We enrolled receiving at Columbia University Medical Center York, NY. They completed questionnaire cancer risk and gave consent access their medical records for biopsy reports past 15 years....
<p>Baseline characteristics of the Know Your Risk: Assessment at Screening (KYRAS) study sample (N=2019) compared to remaining screened cohort not enrolled in KYRAS study, New York, NY (November 2014-October 2015)</p>
<p>Baseline characteristics of the Know Your Risk: Assessment at Screening (KYRAS) study sample (N=2019) compared to remaining screened cohort not enrolled in KYRAS study, New York, NY (November 2014-October 2015)</p>
<div>Abstract<p><b>Background:</b> Potential harms of screening mammography include false positive results, such as recall breast imaging or biopsies.</p><p><b>Methods:</b> We recruited women undergoing at Columbia University Medical Center in New York, York. They completed a questionnaire on cancer risk factors and permitted access to their medical records. Breast status was determined using the Gail model family history screener. High defined...
<div>Abstract<p><b>Background:</b> Potential harms of screening mammography include false positive results, such as recall breast imaging or biopsies.</p><p><b>Methods:</b> We recruited women undergoing at Columbia University Medical Center in New York, York. They completed a questionnaire on cancer risk factors and permitted access to their medical records. Breast status was determined using the Gail model family history screener. High defined...
Abstract Introduction: Chemoprevention with anti-estrogens can reduce breast cancer risk among high-risk women. However, uptake is estimated to be lower than 15% women offered anti-estrogens. Women atypical hyperplasia (AH), lobular carcinoma in situ (LCIS), and ductal (DCIS) are at an increased of developing invasive often derive more benefit from compared other populations. We sought determine which factors associated chemoprevention a population AH, LCIS, DCIS. Methods: conducted...