A5019353148- Reproductive Health and Contraception
- Health Systems, Economic Evaluations, Quality of Life
- Maternal and Perinatal Health Interventions
- Ectopic Pregnancy Diagnosis and Management
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Maternal and fetal healthcare
- Radiomics and Machine Learning in Medical Imaging
- Pharmacovigilance and Adverse Drug Reactions
- Global Maternal and Child Health
- Homicide, Infanticide, and Child Abuse
- Colorectal Cancer Screening and Detection
- Pharmaceutical industry and healthcare
- Breastfeeding Practices and Influences
- Delphi Technique in Research
- Meta-analysis and systematic reviews
- Atrial Fibrillation Management and Outcomes
- Health Policy Implementation Science
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Emergency and Acute Care Studies
- HIV/AIDS Research and Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Gestational Trophoblastic Disease Studies
- Pregnancy and Medication Impact
- Computational Drug Discovery Methods
Bayer (Germany)
2015-2023
Oakland University
2023
Pasadena City College
2023
Uganda Blood Transfusion Service
2021
Kaiser Permanente
2020
Bayer (United States)
2020
Weatherford College
2018
University of Regina
2018
Kimberly-Clark (Canada)
2018
Makerere University
2018
Change of first-line treatment uncomplicated malaria to artemisinin-combination therapy (ACT) is widespread in Africa. To expand knowledge safety profiles ACT, pharmacovigilance activities are included the implementation process changes. Ghana implemented artesunate-amodiaquine 2005. Drug utilization data an important component determining drug safety, and this paper describes how anti-malarials were prescribed within a prospective study following anti-malarial policy change. Patients with...
The aim of this study was to identify characteristics with independent predictive value for bowel cancer use in the clinical assessment patients attending colorectal outpatient clinics.This a 22-year (1986-2007) retrospective cohort analysis data collected prospectively from who attended surgical clinics Portsmouth. set split randomly into two groups generate and validate model. Multivariable logistic regression used create system predict outcome. Receiver operating characteristic (ROC)...
Harmonisation of outcome reporting and definitions for clinical trials routine patient records can enable health care systems to provide more efficient outcome-driven patient-centred interventions. We report on the work PIONEER Consortium in this context prostate cancer (PCa).To update integrate existing core sets (COS) PCa different stages disease, assess their applicability, develop standardised prioritised outcomes.We followed a four-stage process involving: (1) systematic reviews; (2)...
Background. Data directly comparing trends in the use of different oral anticoagulants (OACs) among patients with atrial fibrillation (AF) from countries are limited. We addressed this using a large-scale network cohort study United States (US), Belgium, France, Germany, and Kingdom (UK). Methods. used nine databases (claims or electronic health records) that had been converted into Observational Medical Outcomes Partnership Common Model analysis performed open-source analytical tools....
<h3>Importance</h3> Intrauterine device (IUD) expulsion increases the risk of unintended pregnancy; how timing postpartum IUD insertion and breastfeeding are associated with is relevant to benefit-risk profile. <h3>Objective</h3> To evaluate association status incidence expulsion. <h3>Design, Setting, Participants</h3> The Association Perforation Expulsion Devices (APEX-IUD) cohort study included women aged 50 years or younger an between 2001 2018. analysis focused on a subcohort at 52 fewer...
Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, to wait until palliative treatment needed. PIONEER, funded by European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through application big data analytics. To describe clinical characteristics and long-term outcomes on conservative using international large network real-world data. From initial cohort >100 000...
Pharmacovigilance signal detection largely relies on individual case reports, but longitudinal health data are being explored as complementary information sources. Research to date has focused the ability of epidemiological methods distinguish established adverse drug reactions (ADRs) from unrelated events. The aim this study was evaluate a process for structured clinical and assessment temporally associated drugs medical events in electronic records. Pairs were selected review basis their...
Uniformed service personnel have an increased risk of poor viral load suppression (VLS). This study was performed to evaluate the outcomes interventions improve VLS in 28 military health facilities Uganda.This operational research conducted between October 2018 and September 2019, among people living with HIV (PLHIV) managed by Uganda. Patients a (VL) >1000 copies/ml received three sessions intensive adherence counselling (IAC), 1 month apart, after which repeat VL done. The main outcome...
Aim This study was carried out to determine whether rectal bleeding is related stage of bowel cancer and earlier diagnosis treatment are associated with improved survival. Method Eight hundred forty-five patients were identified in the Wessex Bowel Cancer Audit (1991–1994). Presenting symptoms from case notes. Outcome measures included 5-year survival, Dukes' stage, metastatic disease at surgery time onset treatment, presenting or other signs. Results Six seventy-six (80%) 845 patient notes...
Cyproterone acetate 2 mg/ethinylestradiol 35 µg, an estrogen/progestogen treatment with anti-androgenic properties, shares a thromboembolism risk combined hormonal contraceptives. Educational materials (i.e., direct healthcare professional communication, patient information card, prescriber checklist) were distributed to physicians increase awareness. The objective of this study was measure physician knowledge cyproterone µg and ascertain whether received the educational materials. A...
To validate algorithms identifying uterine perforations and intrauterine device (IUD) expulsions to ascertain availability of breastfeeding status at the time IUD insertion.
Historically, acute medical staffing numbers have been lower on weekends and in winter of admissions rise. An analysis exacerbations chronic obstructive pulmonary disease (AECOPD) to Portsmouth Hospitals over a seven-year period was undertaken examine the effects admission weekend, winter, with opening unit (MAU). In total, 9,915 AECOPD were identified. Weekend accounted for 2,071 (20.9%) cases, 3,026 (30.5%) admissions, 522 (34.4%) deaths. Adjusted odds ratio (OR) death day 1 after weekend...
Background and Aims: The association between gastrointestinal (GI) bleeding subsequent detection of GI cancer in patients using antiplatelet/anticoagulant medications is unclear. We investigated the occurrence assessed whether this differs treated with clopidogrel or warfarin compared to non-treated patients. Methods: A claims analysis was conducted Truven Health MarketScan® Research databases. Patients were grouped into treatment cohort if they received a prescription for non-treatment did...
Intrauterine devices are effective and safe, long-acting reversible contraceptives, but the risk of uterine perforation occurs with an estimated incidence 1 to 2 per 1000 insertions. The European Active Surveillance Study for Devices, a prospective observational study that enrolled 61,448 participants (2006-2012), found women breastfeeding at time device insertion or inserted ≤36 weeks after delivery had higher perforation. Association Uterine Perforation Expulsion Device (APEX-IUD) was Food...
OBJECTIVE: To explore to what extent intrauterine device (IUD) expulsion is associated with demographic and clinical risk factors. METHODS: The APEX-IUD (Association of Perforation Expulsion IntraUterine Devices) study was a U.S. cohort using electronic health records from three integrated care systems (Kaiser Permanente Northern California, Southern Washington) information exchange (Regenstrief Institute). These analyses included individuals aged 50 years or younger IUD insertions 2001...