A5102725737- Dental materials and restorations
- Cleft Lip and Palate Research
- Dental Research and COVID-19
- Orthodontics and Dentofacial Orthopedics
- dental development and anomalies
- Dental Erosion and Treatment
- Craniofacial Disorders and Treatments
- Oral and Maxillofacial Pathology
- Dental Implant Techniques and Outcomes
- Temporomandibular Joint Disorders
- Dental Radiography and Imaging
- Obstructive Sleep Apnea Research
- Mesenchymal stem cell research
- Congenital heart defects research
- Tracheal and airway disorders
- Engineering Technology and Methodologies
- Down syndrome and intellectual disability research
- Neuroscience of respiration and sleep
- Oral Health Pathology and Treatment
- Endodontics and Root Canal Treatments
- Congenital gastrointestinal and neural anomalies
- Cellular transport and secretion
- Nasal Surgery and Airway Studies
- Dysphagia Assessment and Management
- Hearing, Cochlea, Tinnitus, Genetics
Kanagawa Dental University
2024-2025
Mita Hospital
2019-2025
Tokyo Medical and Dental University
2011-2024
Showa University
2014-2023
Yokohama City University
2017-2019
Osaka Prefecture University
2013
Tokai University
2003
Chuo University
2002
Kanazawa Medical University
1998
Keio University Hospital
1991
Abstract Sensorineural hearing loss is a common deficit and mainly occurs due to genetic factors. Recently, copy number variants (CNVs) in the STRC gene have also been recognized as major cause of loss. We investigated frequency deletions Japanese population characteristics associated For CNV analysis, we employed specialized method Ion AmpliSeq TM sequencing, confirmed results via custom array comparative genomic hybridization. identified 17 probands with homozygous deletions. The...
Background/Objectives: A heterozygous mutation in the WFS1 gene is responsible for autosomal dominant non-syndromic hearing loss (DFNA6/14/38) and Wolfram-like syndrome, which characterized by bilateral sensorineural with optic atrophy and/or diabetes mellitus. However, detailed clinical features patients p.A684V variant remain unknown. Methods: We report details of 14 cases a identified from target resequencing analysis 63 previously reported deafness genes next-generation sequencing 15,684...
Objectives This study investigated correlations between facial asymmetry and left-right differences in maxillary sinus size volume, as well their relationships with skeletal morphology. Methods The participants were 154 Japanese adults (56 men, 98 women) aged 18 to 38 years (mean age, 24.1 ± 5.3 years). Cone-beam computed tomography (CBCT) images analyzed using InVivo™ 6 software (Anatomage, Inc., San Jose, CA, USA). Facial was assessed at six landmarks: orbitale, condylion, gonion (all...
PURPOSE To evaluate (1) the initial and long-term microtensile bond strengths of two-step self-etch adhesives with different degrees conversion (DC); (2) elastic modulus respective adhesive resins; (3) water sorption resins. MATERIALS AND METHODS Two adhesives, Clearfil SE Bond (CSE) 2 (CSE2) were used in this study. The DC was determined using ATR/FT-IR a time-based spectrum analysis. Midcoronal flat dentin surfaces 24 human molars prepared 600-grit SiC paper for strength (µTBS) testing....
A heterozygous mutation in the Wolfram syndrome type 1 gene (WFS1) causes autosomal dominant nonsyndromic hereditary hearing loss, DFNA6/14/38, or Wolfram-like syndrome. To date, more than 40 different mutations have been reported to be responsible for DFNA6/14/38. In present study, WFS1 variants were screened a large series of Japanese loss (HL) patients clarify prevalence and clinical characteristics DFNA6/14/38 Massively parallel DNA sequencing 68 target genes was performed 2,549...
Thrombocytopenia (TTP) is a blood disease common to canines and human beings. Currently, there no valid therapy for this except transfusion. In study, we report the generation of canine induced pluripotent stem cells (ciPSCs) from embryonic fibroblasts, novel protocol creating mature megakaryocytes (MKs) functional platelets ciPSCs. The ciPSCs were generated using lentiviral vectors, differentiated into MKs on OP9 stromal supplemented with growth factors. Our presented in tightly domed shape...
The purpose of this study was to compare the dentin bond strength three self-adhesive cements with smear layer pretreatments using a calcium-chelating agent (EDTA) and deproteinizing solution (NaOCl) evaluate their interfacial characteristics. Smear layer-covered surfaces were pretreated EDTA for 60 s, NaOCl 5 15 or none. Three cements; Clearfil SA luting (Kuraray Medical), Rely X Unicem clicker (3M ESPE) Breeze (Pentron) applied surfaces. After 24-h water storage, shear strengths...
This study evaluated the effects of ceramic surface treatment agents on shear bond strengths to materials with and without thermocycling. Ceramic plates were prepared from feldspathic ceramic; AAA, lithium disilicate material; IPS e.max Press, zirconia Lava. surfaces pretreated one five (Clearfil PhotoBond mixed Porcelainbond activator (PB), Clearfil SE One (SO), Primer (CP), Universal (UP), Scotchbond (SU)), then a resin cement (Clapearl DC) was filled. After 0, 5,000, 10,000 thermocycles,...
The purpose of this study was to evaluate the dentin bonding durability three HEMA-containing one-step self-etch adhesives after one-year water storage and measure amounts their sorption/solubility. OptiBond All-In-One (OP), Bond Force (BF) Clearfil S3 (S3) were applied surfaces according manufacturers’ instructions. strengths determined using μTBS test for 24 hours, six months, one year. In addition, sorption solubility polymerized measured. OP significantly decreased On other hand, BF...
Purpose To evaluate the effect of a scrubbing technique with one-step self-etching adhesives on bond strengths and nanoleakage expression at resin/dentin interface. Materials methods Flat human dentin surfaces bonded one two mild adhesives, SE One (SE) or Scotchbond Universal (SU) applied either without technique, were prepared (n = 5). The microtensile (μTBS), micrographs morphological changes treated surfaces, along interfaces as shown TEM evaluated. μTBS data analyzed using two-way ANOVA...
Aim Balanced function of the orofacial muscles is important for normal occlusion and dentition; however, patients with malocclusion often present myofunctional disorder (MFD). Myofunctional therapy (MFT) has received much attention as a method reducing MFD. Moreover, prefabricated functional appliances (PFAs) have been developed to eliminate abnormal muscle pressure guide tongue into correct position. However, PFAs disadvantages, such poor intraoral retention, limited usage time due...
PURPOSE To evaluate the effect of water aging adherend composite on repair bond strength to nanofilled composites with specific fillers using different bonding agents. MATERIALS AND METHODS Three - Beautifil II S-PRG filler (BE) / Filtek Supreme ultra nanocluster (SP) Estelite Σ Quick (ES) and one microhybrid composite, Clearfil APX (AP), were used in this study. The disks immersed for durations (immediate, 1 week, 2 weeks or month), then polished surfaces treated three agents no treatment...
Obstructive sleep apnea syndrome is ascribed to pharyngeal dysfunction, but there are only a few reports about the normal morphological values in this anatomical region. We measured cross-sectional area and compliance (collapsibility), using acoustic reflection technique with air breathing, 181 healthy subjects (age 21–69 years). assessed their sex-related differences, effects of age, body size postures on these parameters. The area, defined as region from fauces glottis, posturally changed...
Abstract Tooth agenesis is described as the absence of one or more teeth. It caused by a failure in tooth development and most common human developmental anomalies. We herein report genomic analyses selective mandibular incisor (SMIA) using exome sequencing. Two Japanese families with SMIA were subjected to sequencing, family sequence similarity 65 member A ( FAM65 ), nuclear factor activated T-cells 3 NFATC3 ) cadherin-related 23 gene CDH23 detected. In follow-up study, 51 32 Korean...
A common disorder of human dentition is the existence supernumerary teeth. Impacted teeth occur most frequently in maxillary incisor area and are termed mesiodens. We conducted whole-exome sequencing non-syndromic Japanese individuals possessing to identify genes and/or loci involved pathogenesis condition.
We evaluated the effect of different curing strategies for universal adhesives on micro-tensile bond strength (μTBS) between resin cement and dentin and/or indirect composite. Flat coronal surfaces composite disks were pretreated with silane-containing adhesives, or without light-curing dentin-side disk-side. Resin luted onto corresponding dual-cure adhesive cements light-cured, cut into beams after 24-h water storage. After 0 10,000 thermocycles (5ºC/55ºC) in a bath, μTBS disk-dentin beam...
The purpose was to evaluate the effect of air-drying dentin surfaces on microtensile bond strength (μTBS) a solvent-free onestep adhesive (Bond 1 SF). Twelve human molars were ground with 600-grit SiC paper. Before applying bonding agent, surface rinsed distilled water and blot-dried tissue paper, followed by for 0, 3, 30, 60 s using dental air syringe. After curing Bond SF, resin composite incrementally built up. Specimens then stored in 24 h μTBSs measured at cross-head speed mm/min....
Objectives/Hypothesis Individuals with orofacial clefts often experience respiratory problems because of nasopharyngeal abnormalities. Pharyngeal airway morphology is thought to differ among the various cleft types. We measured three‐dimensional (3D) volume using cone‐beam computed tomography (CBCT) analysis evaluate and compare pharyngeal airways in Japanese preschoolers without clefts. Study Design Retrospective case‐control study. Methods enrolled 83 subjects (37 boys, 46 girls; mean age...
ABSTRACT Objectives To examine the relationship between mandibular volume and craniofacial morphology in patients with cleft lip palate using cone beam computed tomography (CBCT) to compare these findings control (noncleft) undergoing CBCT for other purposes during deciduous dentition period. Materials Methods Eighty-four were categorized into unilateral alveolus (UCLA) group (n = 25; mean age, 4.60 ± 0.40 years), (UCLP) 23; 4.52 0.39 bilateral (BCLP) 22; 4.54 0.37 without 14; 5.19 0.52...