A5045346387- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Photodynamic Therapy Research Studies
- Conducting polymers and applications
- Advanced biosensing and bioanalysis techniques
- Organic Light-Emitting Diodes Research
- Nanowire Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Chalcogenide Semiconductor Thin Films
- Quantum Dots Synthesis And Properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Magnetism in coordination complexes
- Advanced Polymer Synthesis and Characterization
- Electrostatic Discharge in Electronics
- Copper-based nanomaterials and applications
- Nanoparticle-Based Drug Delivery
- Photochromic and Fluorescence Chemistry
- Microfluidic and Bio-sensing Technologies
- Photoacoustic and Ultrasonic Imaging
- Analytical Chemistry and Sensors
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Organic Electronics and Photovoltaics
- Protein Degradation and Inhibitors
King's College London
2016-2024
University of California, San Francisco
2020-2021
Transnational Press London
2018-2019
Post-polymerization modification of the donor-acceptor polymer, poly(9,9-dioctylfluorene-alt-benzothiadiazole), PF8-BT, by electrophilic C-H borylation is a simple method to introduce controllable quantities near-infrared (near-IR) emitting chromophore units into backbone conjugated polymer. The highly stable borylated unit possesses significantly lower LUMO energy than pristine polymer resulting in reduction band gap up 0.63 eV and red shift emission more 150 nm. Extensively polymers absorb...
Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications bioimaging photosensitizing capabilities has evaluated. The main absorption emission bands of the prepared CPNs both fell within NIR-I (650–950 nm) transparency window, allowing facile efficient implementation our as agents, demonstrated this work for A549 human lung cancer cultures. CPN samples were also shown to produce reactive oxygen...
We report the synthesis of near-infrared (IR)-emitting core/shell/shell quantum dots CuInZnS/ZnSe/ZnS and their phase transfer to water. The intermediate ZnSe shell was added inhibit migration ions from standard ZnS into emitting core, which often leads a blue shift in emission profile. By engineering interface between core terminal layer, optical properties can be controlled, maintained near-IR region, making materials attractive for biological applications. In addition, hydrodynamic...
Recent advances in genome engineering have expanded our capabilities to study proteins their natural states. In particular, the ease and scalability of knocking-in small peptide tags has enabled high throughput tagging analysis endogenous proteins. To improve enrichment capacities expand functionality knock-ins using short tags, we developed tag-assisted split enzyme complementation (TASEC) approach, which uses two orthogonal cognate binders conditionally drive a upon labeled protein...
The synthesis of colloidal semiconductor nanocrystals (NCs) from single-source precursors offers simplified manufacturing processes at the cost reduced atom efficiency. Self-capping routes have potential to maximise this efficiency although investigation has so far been limited organic solvents. Here we present copper sulfide NCs via decomposition a dithiocarbamate complex in water. Nanocrystalline covellite particles were prepared without need for additional capping ligand and exhibited...
Conjugated polymers are organic semiconductors that can be used for fluorescence microscopy of living specimens. Here, we report the encapsulation bright-red-emitting conjugated polymer, poly[{9,9-dihexyl-2,7-bis(1-cyanovinylene)fluorenylene}-alt-co-{2,5-bis(N,N′-diphenylamino)-1,4-phenylene}] (CN-FO-DPD), and superparamagnetic iron oxide nanoparticles (SPIONs) within poly(styrene-co-maleic anhydride) (PSMA) micelles. The resulting particles exhibited an emission peak at 657 nm, a quantum...
ABSTRACT Adoptive chimeric antigen receptor T-cell (CAR-T) therapy is transformative and approved for hematologic malignancies. It also being developed the treatment of solid tumors, autoimmune disorders, heart disease, aging. Despite unprecedented clinical outcomes, CAR-T other engineered cell therapies face a variety manufacturing safety challenges. Traditional methods, such as lentivirus transduction electroporation, result in random integration or cause significant cellular damage, which...
<title>Abstract</title> Adoptive chimeric antigen receptor T-cell (CAR-T) therapy is transformative and approved for hematologic malignancies. It also being developed the treatment of solid tumors, autoimmune disorders, heart disease, aging. Despite unprecedented clinical outcomes, CAR-T other engineered cell therapies face a variety manufacturing safety challenges. Traditional methods, such as lentivirus transduction electroporation, result in random integration or cause significant...
<h3>Background</h3> Cellular immunotherapy using chimeric antigen receptor T cell (CAR T) therapy has revolutionized treatment of patients with hematologic malignancy. Despite success, as many half leukemia experience disease progression. CAR infusion product potency is often compromised by the poor health cells recovered from and intrinsic cellular mechanisms, such activation-induced death (AICD), that limit duration anti-tumor response. To enhance overall efficacy predict potency,...
In this report, we report the synths of colour tuneable conjugated polymer nanoparticles.
Colorectal and prostate cancers are major causes of cancer-related death, with early detection key to increased survival. However, as symptoms occur during advanced stages current diagnostic methods have limitations, there is a need for new fluorescent probes that remain bright, biocompatible can be targeted. Conjugated polymer nanoparticles shown great promise in biological imaging due their unique optical properties. We synthesised small, photo-stable CN-PPV, encapsulated poloxamer thin...
Abstract Recent advances in genome engineering have expanded our capabilities to study proteins their natural states. In particular, the ease and scalability of knocking-in small peptide tags has enabled high throughput tagging analysis endogenous proteins. To improve enrichment capacities expand functionality knock-ins using short tags, we developed tag-assisted split enzyme complementation (TASEC) approach, which uses two orthogonal cognate binders conditionally drive a upon labeled...
Cancer is one of the most serious threats to human health, not only because frequency disease but also severe side effects experienced by patience during chemotherapy and radiotherapy treatments, such as immunosuppression drug resistance. Surgery, a treatment method, does circumvent some effect issues; however, it highly invasive always possible. In this respect, Photodynamic Therapy (PDT), which localizes harmful sensitizer areas exposed radiation, has attracted considerable interest an...
We describe the synthesis of monodispersed, silica encapsulated conjugated polymer nanoparticles, their colour tunability and use in imaging HeLa cells.