A5083385760- Signaling Pathways in Disease
- Immune cells in cancer
- Immune Response and Inflammation
- CAR-T cell therapy research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Nanowire Synthesis and Applications
- Trypanosoma species research and implications
- Single-cell and spatial transcriptomics
- Electrostatic Discharge in Electronics
- Platelet Disorders and Treatments
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Microfluidic and Bio-sensing Technologies
Duke University
2018-2022
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. (Mtb) outbreak presenting with unusually high rates of extrapulmonary dissemination and bone disease. found that the causal strain carried an ancestral full-length version type VII-secreted effector EsxM rather than truncated present in modern Mtb lineages. variant exacerbated through enhancement macrophage motility, increased egress macrophages from...
Highlights•NFAT signaling induces VEGFA in macrophages downstream of a bacterial glycolipid•NFATC2 is required for angiogenesis induced by mycobacterial trehalose 6,6′-dimycolate•Macrophage-specific inhibition NFAT blocks during infection•In vivo, macrophage-specific reduces burdenSummaryDuring infections, pathogenic mycobacteria manipulate both host immune and stromal cells to establish maintain productive infection. In humans, non-human primates, zebrafish models infection, produce modify...
ABSTRACT Adoptive chimeric antigen receptor T-cell (CAR-T) therapy is transformative and approved for hematologic malignancies. It also being developed the treatment of solid tumors, autoimmune disorders, heart disease, aging. Despite unprecedented clinical outcomes, CAR-T other engineered cell therapies face a variety manufacturing safety challenges. Traditional methods, such as lentivirus transduction electroporation, result in random integration or cause significant cellular damage, which...