A5089570926- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroethics, Human Enhancement, Biomedical Innovations
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Posttraumatic Stress Disorder Research
- Psychology of Moral and Emotional Judgment
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Child Abuse and Trauma
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Early Childhood Education and Development
- Estrogen and related hormone effects
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
Emory University
2017-2023
The Wallace H. Coulter Department of Biomedical Engineering
2019-2023
Georgia Institute of Technology
2019-2023
Emory National Primate Research Center
2021
Many neurodegenerative and neurological diseases are rooted in dysfunction of the neuroimmune system; therefore, manipulating this system has strong therapeutic potential. Prior work shown that exposing mice to flickering lights at 40 Hz drives gamma frequency (∼40 Hz) neural activity recruits microglia, primary immune cells brain, revealing a novel method manipulate system. However, biochemical signaling mechanisms between recruitment remain unknown. Here, we exposed wild-type male 5–60 min...
Microglia transform in response to changes sensory or neural activity, such as deprivation. However, little is known about how specific frequencies of brain rhythms, affect microglia and cytokine signaling. Using visual noninvasive flickering stimulation (flicker) induce electrical activity at 40 hertz, within the gamma band, 20 beta we found that these rhythms differentially microglial morphology expression healthy animals. Flicker induced certain cytokines independently microglia,...
Abstract After exposure to a traumatic event, subset of people develop post‐traumatic stress disorder (PTSD). One the key deficits in PTSD is regulation fear, and impaired inhibition fear‐potentiated startle (FPS) has been identified as potential physiological biomarker specific PTSD. As part larger clinical trial, this study investigated effects CRF receptor 1 antagonist, GSK561679, on during conditional discrimination fear‐conditioning paradigm, termed AX+/BX−. Prior research using...
Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple functions, is impaired in many diseases. Despite the therapeutic potential of driving rhythms, methods noninvasively target deep are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights sounds ("flicker"). Flicker drives rhythmic activity superficial regions. Gamma flicker spurs immune function, clears pathogens, rescues memory performance mice with...
Abstract The future of medicine lies not primarily in cures but disease modification and prevention. While the science preclinical detection is young, it moving rapidly. Preclinical interventions offer hope to decrease severity a or delay development disorder. With such promise, research practice detecting brain disorders at stage present unique ethical challenges that must be addressed ensure benefit these technologies. Direct have potential impact just what patient has who they are could...
Dysfunctions in memory recall lead to pathological fear; a hallmark of trauma-related disorders, like posttraumatic stress disorder (PTSD). Both, heightened an association between cue and trauma, as well impoverished that previously is no longer threat, result debilitating fear toward the cue. Glucocorticoid-mediated action via glucocorticoid receptor (GR) influences recall. This literature has primarily focused on GRs expressed neurons or ignored cell-type specific contributions. To ask how...
Abstract Exposure to stress is a risk factor for perturbed mental health, including impoverished regulation of emotional and physiological responses that accompany anxiety mood disorders, substance abuse behavioral disorders. Such disruptions well‐being could be triggered by discrete environmental events or pervasive early life (ELS) resulting example from adverse caregiving. Recent data mostly collected rodents exposed anthropogenic stressors suggest one way via which the detrimental...
Abstract Microglia, the brain’s primary immune cells, transform in response to changes sensory or neural activity, like deprivation. However, little is known about how specific frequencies of brain rhythms, impact microglia and cytokine signaling. Using visual noninvasive flickering stimulation (flicker) induce electrical activity at different frequencies, 40Hz, within gamma band 20Hz, beta band, we discovered these rhythms differentially affect microglial morphology expression healthy...
The editorial staff of AJOB Neuroscience interviewed several speakers and panelists at the 2018 International Neuroethics Society Annual Meeting, held November 1–2 in San Diego, CA. These interview...