A5000918033- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Global Cancer Incidence and Screening
- Viral-associated cancers and disorders
- Blood groups and transfusion
- Animal Virus Infections Studies
- Chronic Myeloid Leukemia Treatments
- Polyomavirus and related diseases
- Homicide, Infanticide, and Child Abuse
- Fungal Plant Pathogen Control
- RNA modifications and cancer
- Olfactory and Sensory Function Studies
- Child and Adolescent Health
- Salivary Gland Disorders and Functions
- Ocular Infections and Treatments
Nantes Université
2020-2025
Université d'Angers
2022-2025
Inserm
2020-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2022-2025
Centre National de la Recherche Scientifique
2022-2025
Centre Hospitalier Universitaire de Nantes
2014-2024
Laboratoire de Thermique et Energie de Nantes
2023
Centre Hospitalier Universitaire de Caen Normandie
2023
Centre Hospitalier Universitaire de Tours
2022
Centre Hospitalier Universitaire d'Angers
2022
Shwachman-Diamond syndrome (SDS) (OMIM #260400) is a rare inherited bone marrow failure (IBMFS) that primarily characterized by neutropenia and exocrine pancreatic insufficiency. Seventy-five to ninety percent of patients have compound heterozygous loss-of-function mutations in the Shwachman-Bodian-Diamond (sbds) gene. Using trio whole-exome sequencing (WES) an sbds-negative SDS family candidate gene additional SBDS-negative cases or molecularly undiagnosed IBMFS cases, we identified 3...
At variance to humoral responses, cellular immunity after anti-SARS-CoV-2 vaccines has been poorly explored in recipients of allogeneic hematopoietic stem-cell transplantation (Allo-HSCT), especially within the first post-transplant years where immunosuppression is more profound and harmful.
Abusive Head Trauma (AHT) is a leading cause of morbidity and mortality in infants requiring rapid neuroimaging performance prognostic diagnosis. The Pittsburgh Infant Brain Injury Score (PIBIS) clinical prediction rule (CPR) was derived to identify most likely present brain injury, whose diagnosis would benefit from head CT. Our study aimed externally validate the PIBIS CPR pediatric French population. A retrospective conducted emergency department between 2015 2017. We included all...
Introduction Poststreptococcal uveitis is among the immune complications following strep infections. Case description A patient treated for acute myeloblastic leukemia presented with febrile neutropenia 22 days after consolidation chemotherapy including cytarabine. Diagnosed Streptococcus mitis bacteremia, she subsequently in her right eye, linked to previous infection through positive anti-streptolysin O and negative microbiological test results. Topical treatment resulted complete...
Mixed phenotype acute leukemia (MPAL) accounts for 2-5% of in children. MPAL are at higher risk induction failure. Lineage switch (B to M or vice versa) persistence only the lymphoid myeloid clone is frequently observed biphenotypic/bilineal cases, highlighting their lineage plasticity. The prognosis remains bleak, with an event-free survival (EFS) less than 50% A lymphoid-type therapeutic approach appears be more effective but failures achieve complete remission (CR) remain significant....
This study aimed to evaluate the incidence of self-reported taste and smell alterations (TSA) in cancer paediatric patients impact TSA on nutritional status this population. We also developed validated a composite score detect children undergoing chemotherapy.Paediatric who were chemotherapy oncology unit included. assessed from Gustonco questionnaire which was internally validated, eating behaviour using Child Eating Behaviour Questionnaire, major weight loss defined status. All data...
A full exploration of immune responses is deserved after anti-SARS-CoV-2 vaccination and boosters, especially in the context allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although several reports indicate successful humoral such patients, literature scarce on cellular specific immunity. Here, both B- (antibodies) T-cell were explored one (V3 n = 40) or two (V4 12) BNT162b2 mRNA vaccine boosters 52 allo-HSCT recipients at a median 755 days post-transplant (<1 year 9)....
The impact of pre-transplant anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine in 20 recipients allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and/or their donors is reported here, showing that the persistence anti-SARS-CoV-2 antibodies can be detected almost all patients, whatever type used, and up to 9 months post transplant. Also, an spike glycoprotein CD3+ T-cell response could six (35%) 17 evaluable patients. This study provides a rationale...
Abstract Immune effector cell‐associated neurotoxicity syndrome (ICANS) is a frequent adverse event after Chimeric antigen receptor T cells (CAR‐T cells). A patient treated with anti‐CD19 CAR‐T for refractory mantle cell lymphoma presented at Day 8 post‐infusion extensive myelitis. Unusual eosinophilia was disclosed in the patient's cerebrospinal fluid. After treatment methylprednisolone and siltuximab, decrease clinical symptoms magnetic resonance imaging lesions were obtained. This...
Abstract Background Thanks to an improved therapeutic regimen in childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), 5 year‐overall survival now exceeds 90%. Unfortunately, the 25% of children who relapse have initial poor prognosis, potentially driven by pre‐existing or emerging molecular anomalies. The latter are initially and essentially identified cytogenetics. However, some subtle alterations not visible through karyotyping. Methods Single nucleotide polymorphisms (SNP)...
In adults, there is a link between socioeconomic status (SES) and cancer prognosis, notably due to increased time diagnosis (TTD) in deprived population leading the dissemination of disease. children, such an association has not been clearly reported. The objective our study was assess impact SES on TTD childhood its potential consequences prognosis. We carried out multicenter retrospective based LOGAFTER multi centric database. studied at individual level (parental professions, family...
Abstract Purpose : In adults, there is a link between socioeconomic status (SES) and cancer prognosis, notably due to increased time diagnosis (TTD) in deprived population leading the spread of disease. children, such an association has not been clearly reported. The objective our study was assess impact SES on TTD childhood its potential consequences prognosis. Methods We carried out multicenter retrospective based LOGAFTER multicentric database. studied at individual ecological levels....
A full-term new-born baby presented with nodular purple cutaneous lesions on the back, legs and face consistent a "blueberry muffin" rash (top left). He had no tumoural syndrome, thoracic or abdominal tumour infection. full blood count showed white cell of 37·71 × 109/l, haemoglobin concentration (Hb) 199 g/l, platelet 214 109/l monocyte 19·4 1·5% neutrophil precursors. Bone marrow (BM) aspiration disclosed 6% myeloid blasts, 17% promonocytes 36% monocytes right). Immunophenotyping...