A5069678606- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA regulation and disease
- Cancer-related gene regulation
- Protist diversity and phylogeny
University of Milan
2022-2024
Antisense RNAs (asRNAs) represent an underappreciated yet crucial layer of gene expression regulation. Generally thought to modulate their sense genes in cis through sequence complementarity or act transcription, asRNAs can also regulate different molecular targets trans, the nucleus cytoplasm. Here, we performed in-depth characterization NFYC 1 (NFYC-AS1), asRNA transcribed head-to-head subunit proliferation-associated NF-Y transcription factor. Our results show that NFYC-AS1 is a...
Aside serving as host gene for miR-205 , MIR205HG transcribes a chromatin-associated long noncoding RNA (lncRNA) able to restrain the differentiation of prostate basal cells, thus being reannotated LEADR (Long Epithelial Alu -interacting Differentiation-related RNA). We previously showed presence sequences in promoters genes modulated upon / manipulation. Notably, an element also spans first and second exons suggesting its possible involvement target selection/binding. Here, we performed...
ABSTRACT Aurora kinase A (AURKA) is a major regulator of the cell cycle. prominent association exists between high expression AURKA and cancer, impairment levels can trigger its oncogenic activity. In order to explore contribution post-transcriptional regulation in different cancers, we carried out meta-analysis -omics data 18 cancer types from The Cancer Genome Atlas (TCGA). Our study confirmed general trend for increased mRNA compared normal tissues revealed that highly dependent on...