A5072070787- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- PARP inhibition in cancer therapy
- Cancer therapeutics and mechanisms
- Diabetes Treatment and Management
- RNA Research and Splicing
- MicroRNA in disease regulation
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Medicinal Plants
- Retinal Diseases and Treatments
- Digestive system and related health
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Autophagy in Disease and Therapy
- Mercury impact and mitigation studies
- Genomics and Chromatin Dynamics
- Cardiovascular Disease and Adiposity
American University in Cairo
2015-2024
University of Notre Dame
2022-2024
University of Wisconsin–Madison
2024
University of Milan
2021-2024
European Institute of Oncology
2019-2022
October University of Modern Sciences and Arts
2018-2022
Al-Azhar University
2018
Herbal remedies have been used for centuries to ameliorate complications of diabetes mellitus (DM). The aim this study is compare the effects oral curcumin supplement versus parenteral administration turmeric extract on diabetic in a streptozocin (STZ) model. STZ DM rats received low and high doses intraperitoneally as well curcumin. Curcumin extracts significantly reduced blood glucose creatinine levels, but not urea, caused an increase uric acid. Low dose improved liver enzymes, while...
Antisense RNAs (asRNAs) represent an underappreciated yet crucial layer of gene expression regulation. Generally thought to modulate their sense genes in cis through sequence complementarity or act transcription, asRNAs can also regulate different molecular targets trans, the nucleus cytoplasm. Here, we performed in-depth characterization NFYC 1 (NFYC-AS1), asRNA transcribed head-to-head subunit proliferation-associated NF-Y transcription factor. Our results show that NFYC-AS1 is a...
Herbal medicine is used by millions of diabetic patients due to economic and cultural factors. The current study investigates the antidiabetic potential fenugreek (Trigonella foenum-graecum) seed extract at a dose 100 mg/kg in Streptozocin-induced model. Male Sprague-Dawley rats received either intraperitoneal [daily (ED) or every other day (EOD)] oral supplement daily, for four weeks. Results show that significantly reduced blood glucose. Urea levels were after daily injection, creatinine...
Diabetes mellitus represents a major independent risk factor for developing fatal cardiovascular diseases (CVDs) presumably through accelerating atherosclerosis; the underlying cause of most CVDs. Notably, this relative is reported to be higher in women than men. Endeavors directed towards identifying novel reliable predictive biomarkers are immensely thereby urged improve long-term outcome these diabetic female patients. Sclerostin (SOST) Wnt signaling antagonist whereas irisin...
Lysine specific demethylase-1 (LSD1) has been shown to be critical in acute myeloid leukemia (AML) pathogenesis and this led the development of LSD1 inhibitors (LSD1i) which are currently tested clinical trials. Nonetheless, preclinical studies reported that AML cells frequently exhibit intrinsic resistance inhibition, molecular basis for phenomenon is largely unknown. We explored potential involvement mammalian target rapamycin (mTOR) mediating leukemic LSD1i. Strikingly, unlike sensitive...
LATS1, the large tumor suppressor 1 gene, encodes for a serine/threonine kinase protein and is implicated in cell cycle progression. LATS1 down-regulated various human cancers, such as breast cancer, astrocytoma. Point mutations were reported sarcomas. Additionally, loss of heterozygosity chromosomal region predisposes to breast, ovarian cervical tumors. In current study, we investigated genetic variations including single nucleotide polymorphisms (SNPs), 28 Egyptian patients with either...
The lower convective layer (LCL) of the Atlantis II brine pool Red Sea is a unique environment in terms high salinity, temperature, and concentrations heavy metals. Mercuric reductase enzymes functional such extreme conditions could be considered potential tool environmental detoxification mercurial poisoning might alleviate ecological hazards mining industry. Here, we constructed mercuric library from II, which identified genes encoding two thermostable (MerA) isoforms: one halophilic...
Breast cancer is the most common type of globally and presents an escalating problem a huge burden on societies. Several strategies are implemented in clinics to treat patients prevent disease incidence. Efforts understand underlying causes emergence pivotal, latest examination human transcriptomic studies showed involvement noncoding RNA regulatory molecules influencing both pathological physiological conditions. molecular mechanisms involved process collaborate develop tumor plasticity...
Non‑coding RNAs (ncRNAs) are involved in different cellular processes and some of them considered to play a role the development numerous diseases. The recent discovery ncRNAs is result several experimental bioinformatics studies. On July 21‑23, 2021, 'Noncoding RNA World: From Mechanism Therapy' conference that was held virtually (originally planned be Basel, Switzerland), gathered experts researchers from countries worldwide cover latest achievements ncRNA research, including basic...
Abstract We studied the activity of recombinant goat PRP14 (gPRP14), a member RID protein family, as xeno-antigen in preclinical models cancer. Antisera from rabbits and mice immunized with gPRP14 showed strong reactivity against several tumor cell types, which was absent towards normal cells: selectivity related to surface intra-cellular expression cells, an exclusively localization cells. In vitro , binding cells followed by cytotoxicity could be rescued addition excess soluble antigen....