A5042929217- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- interferon and immune responses
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Viral Infections and Vectors
- Immunodeficiency and Autoimmune Disorders
- Ubiquitin and proteasome pathways
- Ocular Oncology and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Inflammasome and immune disorders
- CNS Lymphoma Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Connexins and lens biology
- Glaucoma and retinal disorders
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
- Ocular Diseases and Behçet’s Syndrome
- Psoriasis: Treatment and Pathogenesis
- Retinal and Optic Conditions
Chinese University of Hong Kong
2021-2025
Abstract Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune inflammatory diseases. Previously growth hormone releasing receptor (GHRH-R) deficient mice have been reported be less susceptible the induction experimental encephalomyelitis. Here, we show GHRH-R is an important regulator in cell-mediated ocular neural inflammation. We find that not expressed naïve CD4 + T cells, while its expression induced throughout vitro. Mechanistically, activates...
In a study recently published in Science Advances, Wu et al.1 demonstrated that the retinoblastoma protein (pRB) engages cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) cascade via interacting with regulatory factor 3 (IRF3) to initiate senescence hepatic stellate cells, which hampers liver fibrosis. These intriguing findings are important for developing novel therapeutic strategies inducing manipulating cGAS–STING–IRF3–pRB cascade. The cGAS–STING pathway functions as...
Primary open-angle glaucoma (POAG) is the most common form of glaucoma, for which elevated intraocular pressure (IOP) a major risk factor. IOP mainly regulated by dynamic balance aqueous humor (AH) production and outflow via conventional trabecular meshwork/Schlemm's canal (TM/SC) pathway. Dysfunctions TM cells due to endoplasmic reticulum (ER) stress have been demonstrated increase resistance AH outflow, resulting in elevation. Epigallocatechin-3-gallate (EGCG), abundant polyphenolic...
Background/aims To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD OCT) combined with OCT angiography (OCTA) for myopic macular neovascularisation (MNV) activity. Methods Both eyes patients MNV diagnosed fluorescein (FA), SD and OCTA were assessed by unmasked investigators. The images deidentified randomised before graded masked investigators, who determined presence active using together without FA alone, respectively. findings investigators compared...