A5063672054- Apelin-related biomedical research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Nuclear Receptors and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Hypothalamic control of reproductive hormones
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Growth Hormone and Insulin-like Growth Factors
- Paraoxonase enzyme and polymorphisms
- Biochemical Analysis and Sensing Techniques
- Protein Tyrosine Phosphatases
- Effects of Radiation Exposure
- Dietary Effects on Health
Kielanowski Institute of Animal Physiology and Nutrition
2015-2024
Polish Academy of Sciences
2015-2024
S. M. Kirov Military Medical Academy
2013
Competition of commensal and probiotic bacteria with pathogens for adhesion colonization is one the important protective mechanisms gastrointestinal tract. In this study, we examined ability Lactobacillus paracasei to inhibit pathogenic Salmonella enterica human colon adenocarcinoma Caco-2 cells. cells were grown 6 or 21 days obtain nondifferentiated well-differentiated cells, respectively. experiments, added 2 4 hours. The number attached was expressed as colony-forming units (CFUs),...
Colorectal cancer is the third most widely diagnosed cancer. Extracts from snails may modulate growth and development of colorectal cells. The objective this study was to determine chemical composition tissues derived Helix aspersa Müller red-ox properties tissue extracts. Then, influence extracts their fractions different molecular weights on viability Caco-2 cells examined. Tissue lyophilisates contained antioxidants that could be important in prevention Moreover, we confirmed presence a...
1. Abu-Omar N., Das J., Szeto V., Feng Z.-P., 2018. Neuronal ryanodine receptors in development and aging. Mol. Neurobiol. 55, 1183–1192, doi.org/10.1007/s12035-016-0375-4 CrossRef Google Scholar
The study was designed to determine the effects of peripheral injection SB203580 on synthesis interleukin- (IL-) 1 β , IL-6, and tumor necrosis factor (TNF) α in hypothalamus ewes during prolonged inflammation. Inflammation induced by administration lipopolysaccharide (LPS) (400 ng/kg) over 7 days. is a selective ATP-competitive inhibitor p38 mitogen-activated protein kinase (MAPK), which involved regulation proinflammatory cytokines IL-1 IL-6 TNF synthesis. Intravenous successfully...
In vertebrates, numerous processes occur in a rhythmic manner. The hormonal signal reliably reflecting the environmental light conditions is melatonin. Nocturnal melatonin secretion patterns could be disturbed pathophysiological states, including inflammation, Alzheimer’s disease, and depression. All of these states share common elements their aetiology, overexpression interleukin- (IL-) 1 β central nervous system. Therefore, present study was designed to determine effect injection exogenous...
1. Al-Shanti N., Stewart C.E., 2012. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation SOCS-3. J. Cell. Biochem. 113, 923–933, https://doi.org/10.1002/jcb.23.... CrossRef Google Scholar
1. Abo S.M.C., Layton A.T., 2021. Modeling the circadian regulation of immune system: Sexually dimorphic effects shift work. PLOS Comput. Biol. 17, e1008514, https://doi.org/10.1371/journa.... CrossRef Google Scholar
The study was designed to determine the effect of proinflammatory cytokine, interleukin- (IL-) 1 β , on melatonin release and expression enzymes essential for this hormone synthesis: arylalkylamine-N-acetyltransferase (AA-NAT) hydroxyindole-O-methyltransferase (HIOMT) in ovine pineal gland, taking into account immune status animals before sacrificing. Ewes were injected by lipopolysaccharide (LPS; 400 ng/kg) or saline, two hours after sunset during short day period (December). Animals...
Apelin is a regulatory peptide, identified as an endogenous ligand of the receptor (APJ). Both apelin and APJ were detected in brain, lung, heart, mammary gland, kidney, placenta, adipose tissues gastrointestinal tract. considered important gut peptide with potential physiological role cytoprotection, regulation food intake drinking behaviour. The aim present study was to assess effect on mitosis, apoptosis expression DNA repair enzyme (OGG 1/2), intestinal cell lines: rat crypt (IEC-6)...
The study was designed to test the hypothesis that inhibition of acetylcholinesterase (AChE) activity at periphery by Neostigmine (0.5 mg/animal) will be sufficient prevent inflammatory dependent suppression gonadotropin-releasing hormone (GnRH)/luteinising (LH) secretion in ewes follicular phase estrous cycle, and this effect comparable with systemic AChE inhibitor, Donepezil (2.5 mg/animal). An immune/inflammatory challenge induced peripheral administration lipopolysaccharide (LPS; 400...
Caffeine is one of the most widely consumed psychoactive drugs in world. It easily crosses blood–brain barrier, and caffeine-interacting adenosine ryanodine receptors are distributed various areas brain, including hypothalamus pituitary. intake may have an impact on reproductive immune function. Therefore, present study performed ewe model, we decided to investigate effect peripheral administration caffeine (30 mg/kg) secretory activity hypothalamic–pituitary unit which regulates function...
This study investigated the effects of intragastric administration apelin-13 on secretion critical pancreatic hormones in a cohort three-week-old Wistar rats. The research aimed to uncover apelin's modulatory roles endocrine interactions dictating metabolic homeostasis during early life.
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Induced by a bacterial infection, an immune/inflammatory challenge is potent negative regulator of the reproduction process in females. The reduction synthesis pro-inflammatory cytokine considered as effective strategy treatment inflammatory induced neuroendocrine disorders. Therefore, effect direct administration acetylcholinesterase inhibitor-neostigmine-into third ventricle brain on gonadotropin-releasing hormone (GnRH) and luteinizing (LH) secretions under basal immune stress conditions...
The study was designed to examine whether the administration of neostigmine (0.5 mg/animal), a peripheral inhibitor acetylcholinesterase (AChE), during an immune/inflammatory challenge provoked by intravenous injection bacterial endotoxin-lipopolysaccharide (LPS; 400 ng/kg)-attenuates synthesis proinflammatory cytokines in ovine preoptic area (POA), hypothalamic structure playing essential role control reproduction process, and choroid plexus (CP), multifunctional organ sited at interface...