A5034470711- Ocular Surface and Contact Lens
- Air Quality and Health Impacts
- Herpesvirus Infections and Treatments
- Occupational and environmental lung diseases
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Salivary Gland Disorders and Functions
- Skin Protection and Aging
- Corneal surgery and disorders
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Ocular Diseases and Behçet’s Syndrome
- Advanced Glycation End Products research
- Urticaria and Related Conditions
- Respiratory and Cough-Related Research
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 impact on air quality
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Retinal Development and Disorders
- Inhalation and Respiratory Drug Delivery
- Pleural and Pulmonary Diseases
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
Azienda Sanitaria Universitaria Integrata di Trieste
2025
Hospital El Cruce
2022-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
1999-2024
University of Buenos Aires
2013-2023
Centro de Investigaciones Cardiovasculares
2010-2018
Universidad Nacional del Centro de la Provincia de Buenos Aires
2013
Universidad Nacional de La Plata
2012
Universidade de São Paulo
2007-2010
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2007
Cordoba University
1998
Ocular mucosa is exposed constantly to the external environment, and chronic exposure air pollution may affect ocular surface.We assessed effect of on surface by combining determinations individual conjunctival impression cytology.A panel study was conducted with 29 volunteers recruited in two locations different levels: São Paulo (n = 13) Divinolândia 16). We mean levels nitrogen dioxide (NO2) for 7 days, using a passive sampler. Impression cytology samples were obtained from inferior...
To evaluate the efficacy of corneal cross-linking (CXL) (riboflavin-UV-A) as a simple therapy in Fusarium keratitis.Twenty-four rabbits were systemically anesthetized, and stromata their right corneas inoculated with solani [10(5) colony-forming units (CFU) per milliliter]. Rabbits divided into 2 groups: one was treated CXL 72 hours after infection other did not receive any treatment (control). All eyes both groups examined before (days 0 3) (day 7) treatment. The enucleated, buttons sent...
To evaluate the effect of diesel exhaust particles (DEP) on viability, proliferation, apoptosis, secretion cytokines (IL-6, IL-8, and TNF-α), mucin gene transcription (MUC1, MUC5AC, MUC16) in human epithelial cells cornea (HCLE) conjunctiva (IOBA-NHC).HCLE IOBA-NHC were incubated with DEP (10-500 μg/mL) for 24 hours. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Apoptotic measured an annexin V-FITC propidium iodide kit flow cytometry....
Abstract Aims While the exacerbating effect of physical exercise and its correlation with arrhythmic outcomes have been demonstrated for Arrhythmogenic Right Ventricular Cardiomyopathy, impact on other forms cardiomyopathies is poorly characterized. This study aimed to investigate relationship between lifelong intensity development cardiac manifestations in subjects carrying a Likely Pathogenic (LP) or (P) truncating variant titin (TTNtv). Methods TTNtv carriers – patients family members...
To evaluate the efficacy of corneal cross-linking (CXL; riboflavin/ultraviolet A) as a simple therapy for Acanthamoeba keratitis.Twenty rabbits were systemically anesthetized and stroma their right corneas was inoculated with suspension Acanthamoeba. Rabbits divided into 2 groups: one group treated CXL 3 days after infection other did not receive any treatment (control). All eyes in both groups examined before (days 0 3) (day 7) treatment. On day 7, enucleated; 18 buttons (9 each group) sent...
IgG obtained from sera of primary Sjögren's syndrome (pSS-IgG) patients and its interaction with M3 muscarinic cholinoceptors rat exorbital lacrimal glands were studied by indirect immunofluorescence (IFI) binding assay. Primary stained epithelial cells a continuous fluorescence pattern. The IFI imagen was attenuated incubating the pSS-IgG synthetic peptide corresponding to second extracellular loop cholinoceptor. SS-IgG also able bound irreversibly acetylcholine receptors (mAChRs)...
Abstract A new case of rare‐earth (RE) pneumoconiosis is described. The subject had worked as a photoengraver for 13 years and not been exposed 17 years. Chest X‐ray showed diffuse nodular pattern (q 2/3–ILO/1980). patient was asymptomatic despite restrictive spirometric impairment. diagnosis derived from the finding, in bronchoalveolar lavage fluid, abnormal levels La, Ce, Nd, Sm, Tb, Yb, Lu. presence these elements demonstrated by two methods: neutron activation analysis (as regards Ce...
To evaluate the acute impact of wildfire smoke episode in 2008 on ocular surface subjects living Metropolitan Area Buenos Aires (MABA).A total 86 were evaluated: Group 1 comprised patients from a public ophthalmology hospital (N=35) and 2 healthy volunteers (N=51). All answered questionnaire symptoms underwent ophthalmologic examination [bulbar conjunctival hyperemia, corneal fluorescein staining, rose bengal vital tear break-up time (TBUT), Schirmer I test, lysozyme, impression cytology]...
Purpose: The aim of this study was to evaluate oxidative stress markers in human conjunctival epithelial cells (IOBA-NHC) exposed diesel exhaust particles (DEP). Methods: Reactive oxygen (ROS) and nitrogen (RNS) species production; hydrogen peroxide (H2O2) levels; protein oxidation; antioxidant enzymes activities (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], S-transferase [GST], reductase [GR]); total reactive potential (TRAP); reduced (GSH) oxidized (GSSG) were...
Purpose: To evaluate the ability of Systane ® Balance (SYSB) administered four times per day for 4 weeks to increase noninvasive tear film break-up time (NITFBUT) over baseline compared with a saline (SAL) control in patients lipid-deficient dry eye (DE). Patients and methods: aged ≥18 years DE evidence meibomian gland dysfunction (ie, abnormal expression missing glands) were included this randomized, parallel-group, controlled, investigator-masked comparison study. randomized SYSB or SAL...
Purpose: To evaluate the effect of air pollution on ocular surface patients with Sjögren's syndrome.Methods: We investigated surfaces thirty Sjö gren's syndrome and healthy volunteers (control group) living in Metropolitan Area Buenos Aires.We used nitrogen dioxide as an indicator exposure to pollution.An symptoms questionnaire was answered by all subjects, who also underwent a complete ophthalmic examination-including Ocular Surface Disease Index questionnaire, biomicroscopy, tear breakup...
Air pollution is a serious environmental issue worldwide in developing countries’ megacities, affecting the population’s health, including ocular surface, by predisposing or exacerbating other diseases. Herpes simplex keratitis (HSK) caused herpes virus type 1 (HSV-1). The primary recurring infection site causes progressive corneal scarring that may result visual impairment. present study was designed to immunopathological changes of acute HSK under urban polluted air, using model combined...
Abstract Objective To describe the functional and structural characteristics of cornea in healthy Guinea pigs. Animals studied Healthy male female pigmented albino pigs ( Caviaporcellus ) aged 3–5 months old were used. Procedures The animals’ corneas underwent different vivo studies including: slit‐lamp biomicroscopy, fluorescein staining (FS), break‐up time test (BUT), confocal microscopy pachymetry. also histopathologically with light microscopy, immunohistochemistry transmission electron...