A5016285317- Coenzyme Q10 studies and effects
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Advanced battery technologies research
- Pediatric Hepatobiliary Diseases and Treatments
- Air Quality and Health Impacts
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Liver Disease and Transplantation
- Analytical chemistry methods development
- Pregnancy and Medication Impact
- Biochemical effects in animals
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Mitochondrial Function and Pathology
- Climate Change and Health Impacts
- Drug Solubulity and Delivery Systems
- Protein purification and stability
- Adipose Tissue and Metabolism
- Free Radicals and Antioxidants
- Metabolism and Genetic Disorders
- Biochemical Acid Research Studies
- Pharmacological Effects and Toxicity Studies
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
University of Buenos Aires
2015-2024
Instituto de Química y Fisicoquímica Biológicas
2021-2024
Centro Científico Tecnológico - San Juan
2011-2023
Lithuanian University of Health Sciences
2019-2021
Bendigo Health
2021
Australian National University
2021
The University of Adelaide
2021
King's College London
2020
Pharmaceutical Biotechnology (Czechia)
2014
(Abstracted from Lancet 2019;393(10174):899–909) Intrahepatic cholestasis of pregnancy (ICP) affects less than 0.1% to 0.2% pregnant women. It is diagnosed in women with gestational pruritus and increased serum bile acids can be complicated by preterm labor, fetal asphyxia, meconium-stained amniotic fluid, stillbirth.
ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis, including raised SBAs (serum bile acids) and, usually, elevated aminotransferases levels. However, AHP (asymptomatic hypercholanaemia defined as the presence total SBA levels above cut-off value (11 μM) in healthy pregnant women, thus elevation do not necessarily reflect an condition. The aim present study was to describe clinical, obstetric, perinatal findings, well profile, women studied...
The diagnosis and treatment of intrahepatic cholestasis pregnancy (ICP) has important implications on fetal health. biochemical parameter commonly used in the ICP is determination concentration total serum bile acids (TSBA). However, acid profile, especially lithocholic (LCA) analysis a more sensitive specific biomarker for differential this pathology also could be an alternative to evaluate efficiency ursodeoxycholic (UDCA) treatment.Serum (SBA) profiles including LCA determination, were...
Introduction. Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually failure. Bile duct ligated rats constitute an interesting model study the mechanism of cholestasis, its action on several organs tissues, including brain. Aim. To analyze brain bile acids individually in evaluate if profile is altered towards a more toxic condition cholestasis. Material methods. Male Wistar were used separated two groups: sham operated (n = 5 each group). acid was assessed homogenates....
A new CE system based on the use of polymeric-mixed micelles (cholic acid, SDS and poloxamine Tetronic(®) 1107) was developed for simultaneous determination nine steroids in human urine. This method allows baseline separation quantitation cortisol, androstenedione, estriol, dehydroepiandrosterone sulfate, testosterone, dehydroepiandrosterone, estrone, progesterone estradiol less than 25 min showing to be sensitive enough detect low concentrations these urine samples (5-45 ng/mL). The...
Exposure to ambient air particulate matter (PM) is associated with increased cardiorespiratory morbidity and mortality. In this context, alveolar macrophages exhibit proinflammatory oxidative responses as a result of the clearance particles, thus contributing lung injury. However, mechanisms linking these pathways are not completely clarified. Therefore, oxinflammation phenomenon was studied in RAW 264.7 exposed Residual Oil Fly Ash (ROFA), PM surrogate rich transition metals. While cell...
Water from six points the Riachuelo-Matanza basin was analyzed in order to assess ibuprofen biodegradability. In four of them biodegradation proved and degrading bacterial communities were isolated. Biodegradation each point could not be correlated with sewage pollution. The indigenous community isolated localized La Noria Bridge showed highest degradative capacity selected perform batch continuous degradation assays. partial 16S rRNA gene sequence that consisted Comamonas aquatica Bacillus...
A capillary electrophoresis method using CDs for quality control of esomeprazole (ESO) in terms enantiomeric purity and related substances raw material pellets was developed. ESO is the S-enantiomer omeprazole (OMZ). Several parameters were evaluated, including type concentration buffer CD, additives electrolyte pH. Resolution between enantiomers OMZ obtained each parameter tested calculated presence main substance such as sulfone carefully monitored. The optimized system consisted 100 mM...
A stereoselective CD‐MEKC system has been developed for the quality control of Montelukast (MK), commercialized as a pure enantiomer. The proposed method is first one that allows simultaneous determination MK, its enantiomeric form, diasteroisomers and main degradation compound (MK sulphoxide). composed 10 mM SDS, sulfobutylether‐β‐CD, TM‐β‐CD, 20 borate buffer at pH 9.0. Combination these two CDs high baseline enantioresolution between MK impurity, but also, diasteroisomeric forms....
( Lancet . 2019;393:899–909) Intrahepatic cholestasis of pregnancy has been associated with adverse perinatal outcomes, including preterm labor, fetal asphyxia, meconium-stained amniotic fluid, and stillbirth. Although studies have found an increased risk these complications when the serum bile acid concentration is >40 µmol/L, there currently are no to indicate a specific threshold that predictive death. The purpose this systematic review meta-analysis was quantify in relation...
Until now, biochemical parameter for diagnosis of intrahepatic cholestasis pregnancy (ICP) mostly used is the rise total serum bile acids (TSBA) above upper normal limit 11 μM. However, differential very difficult since overlapped values calculated on determinations, are observed in different conditions including benign condition pruritus gravidarum. The aim this work was to determine better markers ICP a precise together with parameters associated severity symptoms and treatment evaluation....