A5110718735- Chronic Myeloid Leukemia Treatments
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Blood properties and coagulation
- Acute Myeloid Leukemia Research
- Hepatitis Viruses Studies and Epidemiology
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Hemostasis and retained surgical items
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Community Development and Social Impact
- Iron Metabolism and Disorders
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
Universidade Estadual de Campinas (UNICAMP)
2015-2024
Hospital Samaritano de São Paulo
2023
Varicella presents a public health challenge in Guatemala, with limited evidence regarding its impact; vaccine is currently absent from the national immunization program. Generating local data on economic and burden can support policies. This study describes use of hospital resources, costs care, clinical demographic characteristics, complications children varicella. A retrospective review medical records patients admitted four institutions Guatemala between January 2015 December 2019,...
The differential diagnosis of immune (ITP) and hereditary macrothrombocytopenia (HM) is key to patient management. immature platelet fraction (IPF) represents the subset circulating platelets with higher RNA content, has been shown distinguish hypo- from hyperproliferative thrombocytopenias. Here we evaluated diagnostic accuracy IPF in between HM other thrombocytopenias a population patients post-chemotherapy thrombocytopenia (n = 56), bone marrow failure 22), ITP 105) 27). TPO levels were...
The development of inhibitory antibodies against factor VIII (FVIII) (inhibitor) is the major complication in haemophilia A patients. FVIII-binding comprises a polyclonal immunoglobulin (Ig) G response. Recent studies showed strong correlation between presence neutralizing anti-FVIII (inhibitors) and IgG4 subclass. aim this study was to evaluate IgG subclasses patients with inhibitor both cross-sectional longitudinal analysis. Inhibitors were determined by Nijmegen-Bethesda assay. Anti-FVIII...
Thrombocytopenia can occur in different circumstances during childhood and although immune thrombocytopenia is its most frequent cause, it important to consider other conditions, especially when there a persistent or recurrent low platelet count. We report two cases of intermittent thrombocytopenia, previously misdiagnosed as thrombocytopenia. Both described were boys who presented with an pattern persistently mean volume. In both patients, peripheral blood smear revealed small platelets...
Summary In contrast to haemophilia B, allergic manifestations are rare complications in A ( HA ) patients treated with factor VIII (FVIII) concentrates. Nevertheless, it can be serious and hamper replacement therapy these cases. The aims of this study were evaluate the frequency reaction a cohort only plasma‐derived FVIII (pdFVIII) concentrates, assess possible immune mechanisms involved. History was retrospectively assessed. Patients followed, had plasma samples collected different...
This study investigates COVID-19 outcomes and immune response in chronic myeloid leukemia (CML) patients post-SARS-CoV-2 vaccination, comparing effectiveness of various vaccine options. Data from 118 CML (85 Brazil, 33 the US) showed similar infection rates prior (14% 9.1% post-vaccination (24.7% vs. 27.3%, respectively). In AstraZeneca CoronaVac were most commonly used brands, while US, Moderna Pfizer-BioNTech vaccines dominated. Despite lower seroconversion Brazilian cohort, all five...
gene do FVW.Confirmamos a mutação em homozigose dois pacientes não relacionados (p.
Topic: 8. Chronic myeloid leukemia - Clinical Background: Patients with hematologic malignancies have displayed lower rates of seroconversion to SARS-CoV-2 vaccines. Hematologic are a heterogeneous group disorders and there is limited data concerning the immunogenicity post-vaccination among chronic (CML) patients, overall by vaccine type. Aims: To analyze following two three doses five different vaccines CML patients. We also explore association between antibody responses, tyrosine kinase...
In Brazil, the National Institute of Cancer estimates for years 2023-2025 about 12,040 new cases NHL, 1,444 peripheral T-cell lymphomas (PTCLs). Brazil project is an ambispective study inserting diagnosis from January 2015 to December 2022. Our goal was explore a prospective cohort (PC), April 2017-December 2022, analyzing primary refractory and relapse (R/R) PTCLs pts bad factors overall survival (OS). PC enrolled 461 who received 1ª treatment line. Descriptive analyses, Kaplan-Meier...
Introduction: Despite substantial progress in the treatment of HL, older pts remain an unmet need. Methods: We sought to identify patterns and outcomes HL ≥ 60 y/o included Brazilian registry. Results: A total 141 with HIV negative classical aged 60, diagnosed from January 2009 December 2018, were identified. Five excluded, leaving 136 available for analysis. The median age was 66 years old (60–90), 49% female, PS >1 21%, advanced stage 72%, anemia 38%, high-risk IPS score 62% nodular...