A5001630876- Advanced Numerical Analysis Techniques
- Neural dynamics and brain function
- Robotic Mechanisms and Dynamics
- Mechanical Engineering and Vibrations Research
- Renal Diseases and Glomerulopathies
- Reproductive Biology and Fertility
- Neuroscience and Neuropharmacology Research
- Computer Graphics and Visualization Techniques
- Manufacturing Process and Optimization
- Assisted Reproductive Technology and Twin Pregnancy
- Iterative Learning Control Systems
- Neural Networks and Applications
- Acute Lymphoblastic Leukemia research
- Reproductive Health and Technologies
- Chronic Kidney Disease and Diabetes
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Dynamics and Control of Mechanical Systems
- Soil Mechanics and Vehicle Dynamics
- Engineering Applied Research
- Systemic Lupus Erythematosus Research
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
Nanyang Technological University
2017-2025
Keio University
2008-2025
Tottori University Hospital
2019
University of California, San Diego
2009-2017
Hitachi (Japan)
2011
Cold Spring Harbor Laboratory
2007-2011
Torrey Pines Institute For Molecular Studies
2007
Norwegian University of Science and Technology
2007
Salk Institute for Biological Studies
2007
Kanagawa Academy of Science and Technology
2004
Neural circuits in the dentate gyrus are continuously modified by adult neurogenesis, whose level is affected animal's experience. However, it not known whether this experience-dependent anatomical modification alters functional properties of gyrus. Here, using expression immediate early gene products, c-fos and Zif268, as indicators recently activated neurons, we show that previous exposure to an enriched environment increases total number new neurons responding reexposure same environment....
The newly synthesized Keio Fluors, which are based on boron-dipyrromethene (BDP), have excellent and useful optical properties: vivid colors sharp emission in the visible−near-infrared region (583−738 nm), high quantum yields (Φ: 0.56−0.98), extinction coefficients (185000−288000 M-1 cm-1), good photostabilities. These properties superior to many of existing fluorescent dyes such as rhodamines, cyanines, or other BDP-based dyes.
Insulin-like growth factor (IGF)-1 plays crucial roles in control and rearrangements of the cytoskeleton. IGF-1 binds to receptor thereby induces autophosphorylation this at its tyrosine residues. The phosphorylation is thought initiate a cascade events. Although various signaling molecules have been identified, they appear interact with tyrosine-phosphorylated receptor. Here, we identified leukemia-associated Rho guanine nucleotide exchange (GEF) (LARG), which contains PSD-95/Dlg/ZO-1...
Reward prediction errors (RPEs) quantify the difference between expected and actual rewards, serving to refine future actions. Although reinforcement learning (RL) provides ample theoretical evidence suggesting that long-term accumulation of these error signals improves efficiency, it remains unclear whether brain uses similar mechanisms. To explore this, we constructed RL-based models used multiregional two-photon calcium imaging in mouse dorsal cortex. We identified a population neurons...
The integration of deep learning and theories reinforcement (RL) is a promising avenue to explore novel hypotheses on reward-based decision-making in humans other animals. Here, we trained RL agents mice the same sensorimotor task with high-dimensional state action space studied representation their respective neural networks. Evaluation thousands network models extensive hyperparameter search revealed that learning-dependent enrichment state-value policy representations...
We analyzed renal biopsy specimens from 100 patients to evaluate the characteristics of involvement in with rheumatoid arthritis (RA). Membranous nephropathy (MN) was most common histological pattern (31%). Mesangial proliferative glomerulonephritis (GN) found 21% cases (IgA 12%, non-IgA GN 9%), minor changes 17%, amyloidosis 11%, interstitial nephritis 9%, sclerotic 4%, and crescentic 2%. MN relatively more frequent men than women, developed nephrotic syndrome, while a few failure....
Abstract The ability to compose new skills from a preacquired behavior repertoire is hallmark of biological intelligence. Although artificial agents extract reusable past experience and recombine them in hierarchical manner, whether the brain similarly composes novel largely unknown. In present study, I show that deep reinforcement learning learn solve composite task by additively combining representations prelearned action values constituent subtasks. Learning efficacy was further augmented...
Measurement of the distribution gas holdup in nitrogen injection into mercury was made by means electroresistivity probe technique with aid high speed data processing system. On basis measurement near an orifice or a nozzle, two regimes flow are distinguished; bubbling and jetting. In jetting regime, jet issuing from tuyere becomes very thin rises rapidly. The radial expands increasing vertical distance due to entrainment surrounding liquid. at which transition behavior plume occurs is about...
Abstract Learning of adaptive behaviors requires the refinement coordinated activity across multiple brain regions. However, how neural communications develop during learning remains poorly understood. Here, using two-photon calcium imaging, we simultaneously recorded layer 2/3 excitatory neurons in eight regions mouse dorsal cortex a delayed-response task. Across learning, while global functional connectivity became sparser, there emerged subnetwork comprising anterior lateral motor (ALM)...
This paper describes trajectory design using clothoid segments. As a path, is superior to the other curves because its curvature varies linearly with curve length. However, single segment not able match both tangent and designation at terminals it has no sufficient parameters. In our study, “triple clothoid” introduced designations. The triple set of three segments connected internally continuity. It parameters needed for matching terminals. are used construct smooth transition passing...