Abstract Peptide‐based self‐assembling systems are increasingly attractive because of their wide range applications in different fields. Peptide nanostructures flexible with changes the ambient conditions. Herein, a reversible shape transition between self‐assembled dipeptide nanotubes (DPNTs) and vesicle‐like structures is observed upon change peptide concentration. SEM, TEM, AFM, CD spectroscopy were used to follow this process. We show that dilution peptide‐nanotube dispersion solution...

Abstract The development of high performance lubricants has been driven by increasingly growing industrial demands and environmental concerns. Herein, we demonstrate oil‐soluble polymer brush‐grafted inorganic nanoparticles (hairy NPs) as highly effective lubricant additives for friction wear reduction. A series oil‐miscible poly(lauryl methacrylate) silica titania NPs were synthesized surface‐initiated atom transfer radical polymerization. These hairy showed exceptional stability in...

The photocatalytic activity enhancement of the ZnO/mpg-C₃N₄ is due to high separation and easy transfer photogenerated electron–hole pairs.

A near-infrared-driven photoelectrochemical aptasensor was developed as a new method for the detection of breast cancer cell MCF-7. The upconversion nanoparticles and TiO2/CdTe heterostructure were combined to prepare film electrode, high-affinity aptamer AS1411 conjugated electrode recognize MCF-7 cells. In this fabrication, transferred near-infrared light visible light, which could excite semiconductor enhance current response. As result, revealed good sensitivity specificity with...

The core-shell gold nanoparticles and copolymer of N-isopropylacrylamide (NIPAM) N,N'-methylenebisacrylamide (MBAA) hybrids (Au@copolymer) were fabricated through surface-initiated atom-transfer radical polymerization (ATRP) on the surface in 2-propanol/water mixed solvents. citrate-stabilized was first modified by a disulfide initiator for ATRP. slight cross-linking between NIPAM MBAA occurred resulted formation Au@copolymer nanostructures that characterized TEM, FTIR UV-visible...

Efficient and divergent one-pot synthesis of fully substituted 1H-pyrazoles isoxazoles from cyclopropyl oximes based on reaction conditions selection is reported. Under Vilsmeier (POCl3/DMF), were synthesized 1-carbamoyl, 1-oximyl cyclopropanes via sequential ring-opening, chlorovinylation, intramolecular aza-cyclization. In the presence POCl3/CH2Cl2, obtained ring-opening nucleophilic vinylic substitution (SNV) reactions.

Polyaniline spherical and cubic shells with hierarchical nanostructures were prepared by using MnO2 hollow different morphologies as reactive templates in a controlled manner. Scanning electron microscopic (SEM) transmission (TEM) images reveal that the PANI as-prepared are narrowly dispersed possess uniform morphologies. Fourier transform infrared (FT-IR) UV−vis spectra of indicate exists emeraldine form. Cyclic voltammogram shows exhibits multiple redox behavior during potentiodynamic...

Hydroxyapatite (HAp), as the main inorganic constituent in vertebrate bones, is an important biomaterial. However, fabricating biomimetic HAp ordered arrays of one-dimensional nanostructures remains a challenge. Herein, we report solvothermal method for preparation nanowire/nanotube with structures using CaCl2 and NaH2PO4·H2O ternary solvents water, ethylene glycol (EG) N,N-dimethylformamide (DMF) without any surfactant. The effects on morphology crystal phase product well formation...

Calcium phosphate is the most important inorganic constituent of biological tissues, and synthetic calcium has been widely used as biomaterials. In this study, a facile method developed for fabrication amorphous (ACP)/polylactide-block-monomethoxy(polyethyleneglycol) hybrid nanoparticles ACP porous nanospheres. Europium-doping performed to enable photoluminescence (PL) function A high specific surface area europium-doped (Eu3+:ACP) nanospheres achieved (126.7 m2/g). PL properties Eu3+:ACP...

Star polymers with a branched core and hydrophilic arms were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization as pH-responsive 19F magnetic resonance imaging (MRI) agents. The consists of 2,2,2-trifluoroethyl acrylate (TFEA, providing MRI signal) 2-(dimethylamino)ethyl methacrylate (DMAEMA, offering properties). are comprised poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) brushes that form biocompatible shells around the cores. structure...

Berberine, a new light-up fluorescence ligand, for i-motif structures has been reported. This interaction enabled the development of label-free DNA-based logic gates in response to input signals.

With the aim of developing stimuli-responsive imaging agents, we report here synthesis core crosslinked star (CCS) polymers and their evaluation as pH-sensitive 19F magnetic resonance (19F MRI) contrast agents. Block copolymers consisting poly(ethylene glycol)methyl ether methacrylate (PPEGMA) first block a copolymer 2-(dimethylamino)ethyl (DMAEMA) 2,2,2-trifluoroethyl (TFEMA) second were synthesised using RAFT polymerisation. The polymerisation kinetics studied in detail. then used arm...

In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide "multi-scale interacting platform" for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) DNA aptamer. After studying performance BSA-aptamer substrates other nanostructured substrates, we can conclude that multisacle could indeed effectively enhance yields cancer cells. The yield artificial blood samples on up 85%–95%,...

Porous carbon materials prepared from the porous organic polymers are currently subject of extensive investigation. On basis their interesting applications, it is highly desirable to develop new synthetic methodologies obtain with controllable pore size and morphology. Herein, a facile synthesis hollow microporous spheres (HCSs) capsules (HMOCs) good control over morphology, cavity, shell thickness reported. The by pyrolysis HMOCs‐based polymers. parameters, such as hypercrosslinking...

Abstract Background Although CDKN2A alteration has been explored as a favorable factor for tumorigenesis in pan-cancers, the association between point mutation (MUT) and intragenic deletion (DEL) response to immune checkpoint inhibitors (ICIs) is still disputed. This study aims determine associations of MUT DEL with overall survival (OS) treatment among pan-cancers clinical features CDKN2A-altered gastric cancer. Methods included 45,000 tumor patients that underwent sequencing across 33...

Passwort? – Vesikel! Ein kationisches Dipeptid lagert sich bei physiologischen pH-Werten zu Nanoröhren zusammen. Diese kationischen Dipeptidnanoröhren (CDPNTs) wandeln beim Verdünnen einer Dispersion spontan in Vesikel um und können dadurch Einzelstrang-DNA über die Membran HeLa-Zellen transportieren (siehe Schema).

A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones is developed via the Vilsmeier−Haack reaction readily available 1-acetyl,1-carbamoyl cyclopropanes, a mechanism involving sequential ring-opening, haloformylation, intramolecular nucleophilic cyclization reactions proposed.

Energy spheres: A biomimetic system consisting of the assembly FoF1 ATPase in lipid-modified polyelectrolyte microcapsules enables adenosine triphosphate (ATP) to be synthesized and stored hollow shells, which thereby act as containers for energy storage (see schematic representation; ADP: diphosphate; Pi: inorganic phosphate).

Abstract Flower‐like nanostructured hydroxyapatite hollow spheres (NHHS) assembled with nanosheets a hierarchical morphology are fabricated by rapid microwave‐assisted hydrothermal route. The presence and concentration of block copolymer poly(lactide)‐block‐poly(ethylene glycol) (PLA–PEG) important parameters for the formation structure. possible mechanism NHHS is proposed. explored as anticancer drug carriers cellular delivery mitoxantrone (MIT). MIT‐loaded exhibit sustained‐drug‐release...

A convenient and efficient synthesis of spiro-fused pyrazolin-5-one N-oxides starting from readily available 1-carbamoyl-1-oximylcycloalkanes is developed. This general protocol features a novel facile way for access to the five-membered azaheterocycles by formation new N−N single bond. The key cyclization step utilizes an N-oxonitrenium intermediate, mediated hypervalent iodine reagent PIFA, its subsequent intramolecular trapping amide moiety under rather mild experimental conditions.